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Antioxidant strategies for Alzheimer's disease

  • Michael Grundman (a1) and Patrick Delaney (a1)


Oxidative damage is present within the brains of patients with Alzheimer's disease (AD), and is observed within every class of biomolecule, including nucleic acids, proteins, lipids and carbohydrates. Oxidative injury may develop secondary to excessive oxidative stress resulting from β-amyloid-induced free radicals, mitochondrial abnormalities, inadequate energy supply, inflammation or altered antioxidant defences. Treatment with antioxidants is a promising approach for slowing disease progression to the extent that oxidative damage may be responsible for the cognitive and functional decline observed in AD. Although not a uniformly consistent observation, a number of epidemiological studies have found a link between antioxidant intake and a reduced incidence of dementia, AD and cognitive decline in elderly populations. In AD clinical trials molecules with antioxidant properties such as vitamin E and Ginkgo biloba extract have shown modest benefit. A clinical trial with vitamin E is currently ongoing to determine if it can delay progression to AD in individuals with mild cognitive impairment. Combinations of antioxidants might be of even greater potential benefit for AD, especially if the agents worked in different cellular compartments or had complementary activity (e.g. vitamins E, C and ubiquinone). Naturally-occurring compounds with antioxidant capacity are available and widely marketed (e.g. vitamin C, ubiquinone, lipoic acid, β-carotene, creatine, melatonin, curcumin) and synthetic compounds are under development by industry. Nevertheless, the clinical value of these agents for AD prevention and treatment is ambiguous, and will remain so until properly designed human trials have been performed.

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Corresponding author

*Dr Michael Grundman, fax +1 858 452 3058, email


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Adams, JD Jr, Klaidman, LK, Odunze, IN, Shen, HCMiller, CA (1991) Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E. Molecular and Chemical Neuropathology 14, 213226.
Bachurin, S, Oxenkrug, G, Lermontova, N, Afanasiev, A, Beznosko, B, Vankin, G, Shevtzova, E, Mukhina, TSerkova, T (1999) N-acetylserotonin, melatonin and their derivatives improve cognition and protect against beta-amyloid-induced neurotoxicity. Annals of the New York Academy of Sciences 890, 155166.
Balestreri, R, Fontana, LAstengo, F (1987) A double-blind placebo controlled evaluation of the safety and efficacy of vinpocetine in the treatment of patients with chronic vascular senile cerebral dysfunction. Journal of the American Geriatrics Society 35, 425430.
Bastianetto, S, Ramassamy, C, Dore, S, Christen, Y, Poirier, JQuirion, R (2000 a) The Ginkgo biloba extract (EGb 761) protects hippocampal neurons against cell death induced by betaamyloid. European Journal of Neuroscience 12, 18821890.
Bastianetto, S, Ramassamy, C, Poirier, JQuirion, R (1999) Dehydroepiandrosterone (DHEA) protects hippocampal cells from oxidative stress-induced damage. Molecular Brain Research 66, 3541.
Bastianetto, S, Zheng, WHQuirion, R (2000 b) The Ginkgo biloba extract (EGb 761) protects and rescues hippocampal cells against nitric oxide-induced toxicity: involvement of its flavonoid constituents and protein kinase C.. Journal of Neurochemistry 74, 22682277.
Bastianetto, S, Zheng, WHQuirion, R (2000 c) Neuroprotective abilities of resveratrol and other red wine constituents against nitric oxide-related toxicity in cultured hippocampal neurons. British Journal of Pharmacology 131, 711720.
Beal, MFMatthews, RT (1997) Coenzyme Q10 in the central nervous system and its potential usefulness in the treatment of neurodegenerative diseases. Molecular Aspects of Medicine 18, Suppl, S169S179.
Behl, C, Davis, J, Cole, GMSchubert, D (1992) Vitamin E protects nerve cells from amyloid beta protein toxicity. Biochemical and Biophysical Research Communications 186, 944950.
Behl, C, Davis, JB, Lesley, RSchubert, D (1994) Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77, 817827.
Behl, C, Skutella, T, Lezoualc'h, F, Post, A, Widmann, M, Newton, CJHolsboer, F (1997) Neuroprotection against oxidative stress by estrogens: structure-activity relatoinship. Molecular Pharmacology 51, 535541.
Bereczki, DFekete, I (1999) A systematic review of vinpocetine therapy in acute ischaemic stroke. European Journal of Clinical Pharmacology 55, 349352.
Berr, C, Balansard, B, Arnaud, J, Roussel, AMAlpérovitch, A (2000) Cognitive decline is associated with systemic oxidative stress: the EVA study. Etude du Vieillissement Artériel. Journal of the American Geriatrics Society 48, 12851291.
Black, JE, Isaacs, KR, Anderson, BJ, Alcantara, AAGreenough, WT (1990) Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proceedings of the National Academy of Sciences USA 87, 55685572.
Borek, C (2001) Antioxidant health effects of aged garlic extract. Journal of Nutrition 131, 1010S1015S.
Bourdel-Marchasson, I, Delmas-Beauvieux, MC, Peuchant, E, Richard-Harston, S, Decamps, A, Reignier, B, Emeriau, JPRainfray, M (2001) Antioxidant defences and oxidative stress markers in erythrocytes and plasma from normally nourished elderly Alzheimer patients. Age and Ageing 30, 235241.
Breteler, MM (2000) Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiology of Aging 21, 153160.
Brewer, GJWallimann, TW (2000) Protective effect of the energy precursor creatine against toxicity of glutamate and beta-amyloid in rat hippocampal neurons. Journal of Neurochemistry 74, 19681978.
Brooks, JO III, Yesavage, JA, Carta, ABravi, D (1998) Acetyl L-carnitine slows decline in younger patients with Alzheimer's disease: a reanalysis of a double-blind, placebo-controlled study using the trilinear approach. International Psychogeriatrics 10, 193203.
Bush, AI, Pettingell, WH, Multhaup, G, de Paradis, M, Vonsattel, JP, Gusella, JF, Beyreuther, K, Masters, CLTanzi, RE (1994) Rapid induction of Alzheimer A beta amyloid formation by zinc. Science 265, 14641467.
Cheng, DHTang, XC (1998) Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacology, Biochemistry and Behaviour 60, 377386.
Chopra, M., Fitzsimons, PE, Strain, JJ, Thurnham, DIHoward, AN (2000) Nonalcoholic red wine extract and quercetin inhibit LDL oxidation without affecting plasma antioxidant vitamin and carotenoid concentrations. Clinical Chemistry 46, 11621170.
Chyan, YJ, Poeggeler, B, Omar, RA, Chain, DG, Frangione, B, Chiso, JPappolla, MA (1999) Potent neuroprotective properties against the Alzheimer beta-amyloid by an endogenous melatonin-related indole structure, indole-3-propionic acid. Journal of Biological Chemistry 274, 2193721942.
Cornett, CR, Markesbery, WREhmann, WD (1998) Imbalances of trace elements related to oxidative damage in Alzheimer's disease brain. Neurotoxicology 19, 339345.
Daniels, WM, van Rensburg, SJ, van Zyl, JMTaljaard, JJ (1998) Melatonin prevents beta-amyloid-induced lipid peroxidation. Journal of Pineal Research 24, 7882.
de Bustos, F, Molina, JA, Jimenez-Jimenez, FJ, Garcia-Redondo, A, Gomez-Escalonilla, C, Porpa-Etessam, J et al. (2000) Serum levels of coenzyme Q10 in patients with Alzheimer's disease. Journal of Neural Transmission 107, 233239.
Dechent, P, Pouwels, PJ, Wilken, B, Hanefeld, FFrahm, J (1999) Increase of total creatine in human brain after oral supplementation of creatine-monohydrate. American Journal of Physiology 277, R698R704.
Deibel, MA, Ehmann, WDMarkesbery, WR (1996) Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: possible relation to oxidative stress. Journal of the Neurological Sciences 143, 137142.
Engelhart, MJ, Ruitenberg, A, Swieten, JC, Witteman, JCM, Hofman, ABreteler, MB (2000) Dietary antioxidants and the risk of dementia. The Rotterdam study. Neurobiology of Aging 21, 203S.
Fagarasan, MOAisen, PS (1996) IL-1 and anti-inflammatory drugs modulate A beta cytotoxicity in PC12 cells. Brain Research 723, 231234.
Fagarasan, MOEfthimiopoulos, S (1996) Mechanism of amyloid beta-peptide (1–42) toxicity in PC12 cells. Molecular Psychiatry 1, 398403.
Fassbender, K, Simons, M, Bergmann, C, Stroick, M, Lutijohamm, D, Keller, P et al. (2001) Simvastatin strongly reduces levels of Alzheimer's disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo. Proceedings of the National Academy of Sciences USA 10, 10.
Foy, CJ, Passmore, AP, Vahidassr, MD, Young, ISLawson, JT (1999) Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease. Quarterly Journal of Medicine 92, 3945.
Frautschy, SA, Harris-White, ME, Miller, SA, Kim, P, Jimenez, I, Csizar, E et al. (2000) Prevention of Aβ amyloid peptide infusion-induced behavioral deficits, neuroinflammation and neurodegeneration by dietary anti-inflammatory/antioxidant supplements. Society for Neuroscience 26, 1830.
Friedland, RP, Fritsch, T, Smyth, K, Koss, E, Lerner, AJ, Chen, CH, Petot, GJDebanne, SM (2001) Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members. Proceedings of the National Academy of Sciences USA 98, 34403445.
Gabuzda, D, Busciglio, J, Chen, LB, Matsudaira, PYankner, BA (1994) Inhibition of energy metabolism alters the processing of amyloid precursor protein and induces a potentially amyloidogenic derivative. Journal of Biological Chemistry 269, 1362313628.
Gonzalez, C, Martin, T, Cacho, J, Brenas, MT, Arroyo, T, Garcia-Berrocal, B, Navajo, JAGonzalez-Buitrago, (1999) Serum zinc, copper, insulin and lipids in Alzheimer's disease epsilon 4 apolipoprotein E allele carriers. European Journal of Clinical Investigation 29, 637642.
Good, PF, Werner, P, Hsu, A, Olanow, CWPerl, DP (1996) Evidence of neuronal oxidative damage in Alzheimer's disease. American Journal of Pathology 149, 2128.
Grant, W (1999) Dietary links to Alzheimer's disease: 1999 update. Journal of Alzheimer's Disease 1, 197201.
Grundman, M (2000) Vitamin E and Alzheimer disease: the basis for additional clinical trials. American Journal of Clinical Nutrition 71, 630S636S.
Grundman, MThal, TJ (2000) Treatment of Alzheimer's disease: rationale and strategies. Neurologic Clinics 18, 807828.
Guevara, J, Espinosa, B, Zenteno, E, Vazguez, I, Luna, J, Perry, GMena, R (1998) Altered glycosylation pattern of proteins in Alzheimer disease. Journal of Neuropathology and Experimental Neurology 57, 905914.
Gulyas, B, Halldin, C, Karlsson, P, Chou, YH, Swahn, CG, Bonock, P, Paroczai, MFarde, L (1999) Brain uptake and plasma metabolism of [11C]vinpocetine: a preliminary PET study in a cynomolgus monkey. Journal of Neuroimaging 9, 217222.
Hager, K, Marahrens, A, Kenklies, M, Riederer, PMunch, G (2001) Alpha-lipoic acid as a new treatment option for Alzheimer type dementia. Archives of Gerontology and Geriatrics 32, 275282.
Hindmarch, I, Fuchs, HHErzigkeit, H (1991) Efficacy and tolerance of vinpocetine in ambulant patients suffering from mild to moderate organic psychosyndromes. International Clinical Psychopharmacology 6, 3143.
Hirai, K, Hayako, H, Kato, KMiyamoto, M (1998) Idebenone protects hippocampal neurons against amyloid beta-peptide-induced neurotoxicity in rat primary cultures. Naunyn Schmiedeburgs Archives of Pharmacology 358, 582585.
Hossain, MS, Hashimoto, M, Gamoh, SMasumura, S (1999) Antioxidative effects of docosahexaenoic acid in the cerebrum versus cerebellum and brainstem of aged hypercholesterolemic rats. Journal of Neurochemistry 72, 11331138.
Huang, X, Cuajungco, MP, Atwood, CS, Moir, RD, Tanzi, REBush, I (2000) Alzheimer's disease, beta-amyloid protein and zinc. Journal of Nutrition 130, 1488S1492S.
Isaacs, KR, Anderson, BJ, Alcantara, AA, Black, JEGreenough, WT (1992) Exercise and the brain: angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning. Journal of Cerebral Blood Flow and Metabolism 12, 110119.
Jama, JW, Launer, LJ, Witteman, JC, den Breeijen, JH, Breteler, MM, Grobbee, DEHofman, A (1996) Dietary antioxidants and cognitive function in a population-based sample of older persons. The Rotterdam Study. American Journal of Epidemiology 144, 275280.
Jeandel, C, Nicolas, MB, Dubois, F, Nabet-Belleville, F, Pennin, FCuny, G (1989) Lipid peroxidation and free radical scavengers in Alzheimer's disease. Gerontology 35, 275282.
Jeyarajah, DR, Kielar, M, Penfield, JLu, CY (1999) Docosahexaenoic acid, a component of fish oil, inhibits nitric oxide production in vitro. Journal of Surgical Research 83, 147150.
Jick, H, Zornberg, GL, Jick, SS, Seshadri, SDrachman, DA (2000) Statins and the risk of dementia. Lancet 356, 16271631.
Jimenez-Jimenez, FJ, de Bustos, F, Gasalla, TOrti-Pareja, M (1996) Estres oxidativo y sistema nervioso central (oxidative stress in the central nervous system). Neurologia 11, 1322.
Jimenez-Jimenez, FJ, de Bustos, F, Molina, JA, Benito-Leon, J, Tallon-Barranco, A, Gasalla, T, Orti-Pareja, M, Guillaman, F, Rubio, JC, Arenas, JEnriquez-de-Salamanca, R (1997) Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease. Journal of Neural Transmission 104, 703710.
Kalmijn, S, Launer, LJ, Ott, A, Witteman, JC, Hofman, ABreteler, MM (1997) Dietary fat intake and the risk of incident dementia in the Rotterdam Study. Annals of Neurology 42, 776782.
Kempermann, G, Kuhn, HGGage, FH (1997) More hippocampal neurons in adult mice living in an enriched environment. Nature 386, 493495.
Kihara, T, Shimohama, S, Sawada, H, Kimura, J, Kume, T, Kochiyama, H, Maeda, TAkaike, A (1997) Nicotinic receptor stimulation protects neurons against beta-amyloid toxicity. Annals of Neurology 42, 159163.
Kim, DS, Park, SYKim, JK (2001) Curcuminoids from Curcuma longa L. (Zingiberaceae) that protect PC12 rat pheochromocytoma and normal human umbilical vein endothelial cells from betaA (1–42) insult. Neuroscience Letters 303, 5761.
Kim, YC, Kim, SR, Markelonis, GJOh, TH (1998) Ginsenosides Rbl and Rg3 protect cultured rat cortical cells from glutamate-induced neurodegeneration. Journal of Neuroscience Research 53, 426432.
Kyle, DJ, Schaefer, E, Patton, GBeiser, A (1999) Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. Lipids 34, S245.
La Rue, A, Koehler, KM, Wayne, SJ, Chiulli, SJ, Haaland, KYGarry, PJ (1997) Nutritional status and cognitive functioning in a normally aging sample: a 6-y reassessment. American Journal of Clinical Nutrition 65, 2029.
Le Bars, PL, Kieser, MItil, KZ (2000) A 26-week analysis of a double-blind, placebo-controlled trial of the ginkgo biloba extract EGb 761 in dementia. Dementia Geriatrics and Cognitive Disorders 11, 230237.
Lerner, AJ, Mizrahi, EH, Chen, CH, Eckman, C, Younkin, SSiavalas, EL et al. (2000) Relationship of plasma amyloid beta fragments to serum cholesterol, high density lipoprotein, albumin, and apolipoprotein E genotype. Neurology 54, A366.
Liu, F, Lau, BH, Peng, QShah, V (2000) Pycnogenol protects vascular endothelial cells from beta-amyloid-induced injury. Biological and Pharmaceutical Bulletin 23, 735737.
Lovell, MA, Ehmann, WD, Butler, SMMarkesbery, WR (1995) Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease. Neurology 45, 15941601.
Lovell, MA, Gabbita, SPMarkesbery, WR (1999 a) Increased DNA oxidation and decreased levels of repair products in Alzheimer's disease ventricular CSF. Journal of Neurochemistry 72, 771776.
Lovell, MA, Xie, CMarkesbery, WR (1999 b) Protection against amyloid beta peptide toxicity by zinc. Brain Research 823, 8895.
Maes, M, DeVos, N, Wauters, A, Demedts, P, Maurits, VW, Neels, H et al. (1999) Inflammatory markers in younger vs elderly normal volunteers and in patients with Alzheimer's disease. Journal of Psychiatric Research 33, 397405.
Marcus, DL, Thomas, C, Rodriguez, C, Simberkoff, K, Tsai, JS, Strafaci, JAFreedman, ML (1998) Increased peroxidation and reduced antioxidant enzyme activity in Alzheimer's disease. Experimental Neurology 150, 4044.
Mark, RJ, Keller, JN, Kruman, IMattson, MP (1997) Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K + -ATPase activity in hippocampal neurons. Brain Research 756, 205214.
Markesbery, WRLovell, MA (1998) Four-hydroxynonenal, a product of lipid peroxidation, is increased in the brain in Alzheimer's disease. Neurobiology of Aging 19, 3336.
Masaki, KH, Losonczy, KZ, Izmirlian, G, Foley, DJ, Ross, GW, Petrovitch, H, Havlik, RWhite, LR (2000) Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 54, 12651272.
Mecocci, P, MacGarvey, UBeal, MF (1994) Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Annals of Neurology 36, 747751.
Meseguer, I, Molina, JA, Jimenez-Jimenez, FJ, Aguilar, MV, Mateo-Vega, CJ, Gonzalez-Munoz, MJ et al. (1999) Cerebrospinal fluid levels of selenium in patients with Alzheimer's disease. Journal of Neural Transmission 106, 309315.
Metcalfe, T, Bowen, DMMuller, DP (1989) Vitamin E concentrations in human brain of patients with Alzheimer's disease, fetuses with Down's syndrome, centenarians, and controls. Neurochemical Research 14, 12091212.
Misonou, H, Morishima-Kawashima, MIhara, Y (2000) Oxidative stress induces intracellular accumulation of amyloid beta-protein (Abeta) in human neuroblastoma cells. Biochemistry 39, 69516959.
Molina, JA, Jimenez-Jimenez, FJ, Aguilar, MV, Meseguer, I, Mateos-Vega, CJ, Gonzalez-Munoz, MJ et al. (1998) Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. Journal of Neural Transmission 105, 479488.
Moreira, P, Pereira, C, Santos, MSOliveira, C (2000) Effect of zinc ions on the cytotoxicity induced by the amyloid beta-peptide. Antioxidant Redox Signal 2, 317325.
Morris, MC, Evans, DA, Bienias, JL, Wilson, RSTangney, CC (2000) Dietary intake of vitamin C and vitamin E and cognitive decline in a biracial community programme. Neurobiology of Aging 21, S202.
Morris, MC, Beckett, LA, Scherr, PA, Hebert, LE, Bennett, DA, Field, TSEvans, DA (1998) Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease. Alzheimer Disease and Associated Disorders 12, 121126.
Mullaart, E, Boerrigter, ME, Ravid, R, Swaab, DFVijg, J (1990) Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients. Neurobiology of Aging 11, 169173.
Muller, WE, Romero, FJ, Perovic, S, Pergande, GPialoglou, P (1997) Protection of flupirtine on beta-amyloid-induced apoptosis in neuronal cells in vitro: prevention of amyloidinduced glutathione depletion. Journal of Neurochemistry 68, 23712377.
Notkola, IL, Sulkava, R, Pekkanen, J, Erkinjuntti, T, Ehnholm, C, Kivinen, P, Tuomilehto, JNissinen, A (1998) Serum total cholesterol, apolipoprotein E epsilon 4 allele, and Alzheimer's disease. Neuroepidemiology 17, 1420.
Nourooz-Zadeh, J, Liu, EH, Yhlen, B, Anggard, EEHalliwell, B (1999) F4-isoprostanes as specific marker of docosahexaenoic acid peroxidation in Alzheimer's disease. Journal of Neurochemistry 72, 734740.
Nunomura, A, Perry, G, Pappolla, MA, Wade, R, Hirai, K, Chiba, SSmith, MA (1999) RNA oxidation is a prominent feature of vulnerable neurons in Alzheimer's disease. Journal of Neuroscience 19, 19591964.
Oken, BS, Storzbach, DMKaye, JA (1998) The efficacy of Ginkgo biloba on cognitive function in Alzheimer disease. Archives of Neurology 55, 14091415.
Olivieri, G, Baysang, G, Meier, F, Muller-Spahn, F, Stahelin, HB, Brockhaus, MBrack, C (2001) N-acetyl-L-cysteine protects SHSY5Y neuroblastoma cells from oxidative stress and cell cytotoxicity: effects on beta-amyloid secretion and tau phosphorylation. Journal of Neurochemistry 76, 224233.
Orgogzo, JM, Dartigues, JF, Lafontr, S, Letenneur, L, Commenges, D, Salamon, R, Renaud, SBreteler, MB (1997) Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Revue Neurologique 153, 185192.
Packer, L, Tritschler, HJWessel, K (1997) Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radical Biology and Medicine 22, 359378.
Paleologos, M, Cumming, RGLazarus, R (1998) Cohort study of vitamin C intake and cognitive impairment. American Journal of Epidemiology 148, 4550.
Pappolla, MA, Sos, M, Omar, RA, Bick, RJ, Hickson-Bick, DL, Reiter, RJ, Efthimiopoulos, SRobakis, NK (1997) Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. Journal of Neuroscience 17, 16831690.
Pereira, C, Agostinho, POliveira, CR (2000) Vinpocetine attenuates the metabolic dysfunction induced by amyloid betapeptides in PC12 cells. Free Radical Research 33, 497506.
Pereira, C, Santos, MSOliveira, C (1999) Involvement of oxidative stress on the impairment of energy metabolism induced by A beta peptides on PC12 cells: protection by antioxidants. Neurobiology of Disease 6, 209219.
Perkins, AJ, Hendrie, HC, Callahan, CM, Gao, S, Unverzagt, FW, Xu, Y, Hall, KSHui, SL (1999) Association of antioxidants with memory in a multiethnic elderly sample using the Third National Health and Nutrition Examination Survey. American Journal of Epidemiology 150, 3744.
Perrig, WJ, Perrig, PStahelin, HB (1997) The relation between antioxidants and memory performance in the old and very old. Journal of the American Geriatrics Society 45, 718724.
Pfefferbaum, A, Adalsteinsson, E, Spielman, D, Sullivan, EVLim, KO (1999) In vivo brain concentrations of N-acetyl compounds, creatine, and choline in Alzheimer disease. Archives of General Psychiatry 56, 185192.
Prasad, MR, Lovell, MA, Yatin, M, Dhillon, HMarkesbery, WR (1998) Regional membrane phospholipid alterations in Alzheimer's disease. Neurochemical Research 23, 8188.
Pratico, D, Clark, CM, Lee, VM, Trojanowski, JQ, Rokach, JFitzGerald, GA (2000) Increased 8, 12-iso-iPF2alpha-VI in Alzheimer's disease: correlation of a noninvasive index of lipid peroxidation with disease severity. Annals of Neurology 48, 809812.
Pratico, DDelanty, N (2000) Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. American Journal of Medicine 109, 577585.
Refolo, LM, Pappolla, MA, Malester, B, LaFrancois, J, Bryant-Thomas, T, Wang, R, Tint, GS, Sambanurti, KDuff, K (2000) Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiology of Disease 7, 321331.
Rischke, RKrieglstein, J (1990) Effects of vinpocetine on local cerebral blood flow and glucose utilization seven days after forebrain ischemia in the rat. Pharmacology 41, 153160.
Riviere, S, Birlouez-Aragon, I, Nourhashemi, FVellas, B (1998) Low plasma vitamin C in Alzheimer patients despite an adequate diet. International Journal of Geriatric Psychiatry 13, 749754.
Romas, SN, Tang, MX, Berglund, LMayeux, R (1999) APOE genotype, plasma lipids, lipoproteins, and AD in community elderly. Neurology 53, 517521.
Roth, A, Schaffner, WHertel, C (1999) Phytoestrogen kaempferol (3,4′,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity. Journal of Neuroscience Research 57, 399404.
Rottkamp, CA, Nunomura, A, Raina, AK, Sayre, LM, Perry, GSmith, MA (2000) Oxidative stress, antioxidants, and Alzheimer disease. Alzheimer Disease and Associated Disorders 14, S62S66.
Rottkamp, CA, Raina, AK, Zhu, X, Gaier, E, Bush, AI, Attwood, CS, Chevion, M, Perry, GSmith, MA (2001) Redox-active iron mediates amyloid-beta toxicity. Free Radical Biology and Medicine 30, 447450.
Samudralwar, DL, Diprete, CC, Ni, BF, Ehmann, WDMarkesbery, WR (1995) Elemental imbalances in the olfactory pathway in Alzheimer's disease. Journal of the Neurological Sciences 130, 139145.
Sano, M, Ernesto, C, Thomas, RG, Klauber, MR, Schafer, K, Grundman, M et al. (1997 a) A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. New England Journal of Medicine 336, 12161222.
Sano, M, Thomas, RGThal, LJ (1997 b) Alpha-tocopherol and Alzheimer's disease. New England Journal of Medicine 337, 573.
Schippling, S, Kontush, A, Arlt, S, Buhmann, C, Sturenburg, HJ, Mann, U, Muller-Thomsen, TBeisiegel, U (2000) Increased lipoprotein oxidation in Alzheimer's disease. Free Radical Biology and Medicine 28, 351360.
Schmidt, R, Hayn, M, Reinhart, B, Roob, G, Schmidt, H, Schumacher, M, Watzinger, NLauner, LJ (1998) Plasma antioxidants and cognitive performance in middle-aged and older adults: results of the Austrian Stroke Prevention Study. Journal of the American Geriatrics Society 46, 14071410.
Sinclair, AJ, Bayer, AJ, Johnston, J, Warner, CMaxwell, SR (1998) Altered plasma antioxidant status in subjects with Alzheimer's disease and vascular dementia. International Journal of Geriatric Psychiatry 13, 840845.
Smith, MA, Perry, G, Richey, PL, Sayre, LM, Anderson, VE, Beal, MFKowall, N (1996) Oxidative damage in Alzheimer's. Nature 382, 120121.
Smith, MA, Richey Harris, PL, Sayre, LM, Beckman, JSPerry, G (1997) Widespread peroxynitrite-mediated damage in Alzheimer's disease. Journal of Neuroscience 17, 26532657.
Smith, MA, Rottkamp, CA, Nunomura, A, Raina, AKPerry, G (2000) Oxidative stress in Alzheimer's disease. Biochimica et Biophysica Acta 1502, 139144.
Soderberg, M, Edlund, C, Alafuzoff, I, Kristensson, KDallner, G (1992) Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type. Journal of Neurochemistry 59, 16461653.
Soderberg, M, Edlund, C, Kristensson, KDallner, G (1991) Fatty acid composition of brain phospholipids in aging and in Alzheimer's disease. Lipids 26, 421425.
Sparks, DL, Martin, TA, Gross, DRHunsaker, JC 3rd (2000) Link between heart disease, cholesterol, and Alzheimer's disease: a review. Microscopy Research and Technique 50, 287290.
Subhan, ZHindmarch, I (1985) Psychopharmacological effects of vinpocetine in normal healthy volunteers. European Journal of Clinical Pharmacology 28, 567571.
Subramaniam, R, Koppal, T, Green, M, Yatin, S, Jordan, B, Drake, JButterfield, DA (1998) The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid betapeptide(25–35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease. Neurochemical Research 23, 14031410.
Suh, SW, Jensen, KB, Jensen, MS, Silva, DS, Kesslak, PJ, Danscher, GFrederickson, CJ (2000) Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains. Brain Research 852, 274278.
Svensson, ALNordberg, A (1998) Tacrine and donepezil attenuate the neurotoxic effect of A beta(25–35) in rat PC12 cells. Neuroreport 9, 15191522.
Tarnopolsky, MABeal, MF (2001) Potential for creatine and other therapies targeting cellular energy dysfunction in neurological disorders. Annals of Neurology 49, 561574.
Terano, T, Fujishiro, S, Ban, T, Yamamoto, K, Tanaka, T, Noguchi, Y, Tamura, Y, Yazawa, KHirayama, T (1999) Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. Lipids 34, S345S346.
Thal, LJ, Calvani, M, Amato, ACarta, A (2000) A 1 -year controlled trial of acetyl-l-carnitine in early-onset AD. Neurology 55, 805810.
Thal, LJ, Carta, A, Clarke, WR, Ferris, SH, Friedland, RP, Petersen, RC et al. (1996) A 1-year multicenter placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's disease. Neurology 47, 705711.
Thal, LJ, Salmon, DP, Lasker, B, Bower, DKlauber, MR (1989) The safety and lack of efficacy of vinpocetine in Alzheimer's disease. Journal of the American Geriatrics Society 37, 515520.
Vitek, MP, Bhattacharya, K, Glendening, JM, Stopa, E, Vlassara, H, Bucala, R, Manogue, KCerami, A (1994) Advanced glycation end products contribute to amyloidosis in Alzheimer disease. Proceedings of the National Academy of Sciences USA 91, 47664770.
Wang, TTang, XC (1998) Reversal of scopolamine-induced deficits in radial maze performance by (−)-huperzine A: comparison with E2020 and tacrine. European Journal of Pharmacology 349, 137142.
Wei, H, Leeds, PR, Qian, Y, Wei, W, Chen, RChuang, D (2000) Beta-amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment. European Journal of Pharmacology 392, 117123.
Wesnes, KA, Ward, T, McGinty, APetrini, O (2000) The memory enhancing effects of a Ginkgo biloba/Panax ginseng combination in healthy middle-aged volunteers. Psychopharmacology (Berlin) 152, 353361.
Wolozin, B, Kellman, W, Celesia, GSiegel, G (1999) Decreased prevalence of Alzheimer's disease associated with HMG-CoA reductase inhibitors. Journal of the Neurological Sciences 25, 16(13.9).
Xiao, QX, Wang, R, Han, YFTang, XC (2000 a) Protective effects of hyperzine A on beta-amyloid 25–35 induced oxidative injury in rat pheochromocytoma cells.. Neuroscience Letters 286, 155158.
Xiao, QX, Wang, RTang, XC (2000 b) Huperzine A and tacrine attenuate beta-amyloid peptide-induced oxidative injury. Journal of Neuroscience Research 61, 564569.
Xu, SS, Gao, ZX, Weng, Z, Du, ZM, Xu, WA, Yang, JS, Zhang, ML, Tong, ZH, Fang, YSChai, XS (1995) Efficacy of tablet huperzine-A on memory, cognition, and behavior in Alzheimer's disease. Chung Kuo Yao Li Hsueh Pao 16, 391395.
Yallampalli, S, Micci, MATaglialatela, G (1998) Ascorbic acid prevents beta-amyloid-induced intracellular calcium increase and cell death in PC12 cells. Neuroscience Letters 251, 105108.
Yan, JJ, Cho, JY, Kim, HS, Kim, KL, Jung, JS, Huh, SO, Suh, HW, Kim, YHSong, DK (2001) Protection against beta-amyloid peptide toxicity in vivo with long-term administration of ferulic acid. British Journal of Pharmacology 133, 8996.
Yan, SD, Chen, X, Schmidt, AM, Brett, J, Godman, G, Zou, YS, Scott, CW, Caputo, C, Frappier, TSmith, MA (1994) Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress. Proceedings of the National Academy of Sciences USA 91, 77877791.
Yao, Z, Drieu, KPapadopoulos, V (2001) The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from betaamyloid-induced cell death by inhibiting the formation of betaamyloid-derived diffusible neurotoxic ligands. Brain Research 889, 181190.
Yatin, SM, Yatin, M, Aulick, T, Ain, KBButterfield, DA (1999) Alzheimer's amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E. Neuroscience Letters 263, 1720.
Ye, JW, Cai, JX, Wang, LMTang, XC (1999) Improving effects of huperzine A on spatial working memory in aged monkeys and young adult monkeys with experimental cognitive impairment. Journal of Pharmacology and Experimental Therapeutics 288, 814819.
Zaman, Z, Roche, S, Fielden, P, Frost, PG, Niriella, DCCayley, AC (1992) Plasma concentrations of vitamins A and E and carotenoids in Alzheimer's disease. Age and Ageing 21, 9194.
Zhang, RW, Tang, XC, Han, YY, Sang, GW, Zhang, YD, Ma, YX, Zhang, CLYang, RM (1991) Drug evaluation of huperzine A in the treatment of senile memory disorders. Chung Kuo Yao Li Hsueh Pao 12, 250252.
Zhou, Y, Gopalakrishnan, VRichardson, JS (1996) Actions of neurotoxic beta-amyloid on calcium homeostasis and viability of PC 12 cells are blocked by antioxidants but not by calcium channel antagonists. Journal of Neurochemistry 67, 14191425.
Zhou, YRichardson, JS (1996) Cholesterol protects PC12 cells from beta-amyloid induced calcium disordering and cytotoxicity. Neuroreport 7, 24872490.


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