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The co-evolution of people, plants, and parasites: biological and cultural adaptations to malaria*

Published online by Cambridge University Press:  05 March 2007

Nina L. Etkin
Nina L. Etkin*
Affiliation:
Department of Anthropology and Division of Health Ecology (School of Medicine), University of Hawaii, Honolulu, Hawaii, USA
*
Corresponding author: Professor Nina L. Etkin, fax +1 808956 4893, etkin@hawaii.edu
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Abstract

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The urgency generated by drug-resistant strains of malaria has accelerated anti-malarial drug research over the last two decades. While synthetic pharmaceutical agents continue to dominate research, attention increasingly has been directed to natural products. The present paper explores the larger context in which plant use occurs and considers how the selection of medicinal plants has evolved over millennia as part of the larger human effort to mediate illness. First attention is directed to indigenous medicinal plants whose anti-malarial activity is based on an oxidant mode of action, by which intracellular constituents lose electrons (become more electropositive). Next, parallels are drawn between these plant substances and a suite of malaria-protective genetic traits: glucose-6-phosphate dehydrogenase deficiency; haemoglobins S, C and E; α- and β-thalassemias. These erythrocyte anomalies are classic examples of Darwinian evolution, occurring in high frequency in populations who have experienced considerable selective pressure from malaria. Characterized by discrete loci and pathophysiologies, they are united through the phenomenon of increased erythrocyte oxidation. In this model, then, oxidant anti-malarial plants are culturally constructed analogues, and molecular mimics, of these genetic adaptations. To further reinforce the scheme, it is noted that the anti-malarial action of pharmaceutical agents such as chloroquine and mefloquine duplicates both the genetic anomalies and the folk therapeutic models based in oxidant plants. This discussion coheres around a theoretical foundation that relates plant secondary metabolites (oxidants) to plasmodial biochemistry and human biological and cultural adaptations to malaria. Co-evolution provides a theoretical link that illuminates how medical cultures manage the relationships among humans, plants, herbivores and their respective pathogens.

Keywords

MalariaCo-evolutionOxidationErythrocyte disordersMedicinal plants
Type
Plenary Lecture
Information
Proceedings of the Nutrition Society , Volume 62 , Issue 2 , May 2003 , pp. 311 - 317
Copyright
Copyright © The Nutrition Society 2003

Footnotes

*

This paper is a fully reconceptualized and updated expansion of an earlier publication (Etkin, 1997).

References

Adelekan, DA & Thurnham, DI (1998) Glutathione peroxidase (EC 1.11.1.9) and superoxide dismutase (EC 1.15.1.1) activities in riboflavin-deficient rats infected with Plasmodium berghei malaria.. British Journal of Nutrition 79, 305–309CrossRefGoogle ScholarPubMed
Akendengue, B, Ngou-Milama, E, Roblot, F, Laurens, A, Hocqquemiller, R, Grellier, P & Frappier, F (2002) Antiplasmodial activity of Uvaria klaineana.. Planta Medica 68, 167–169CrossRefGoogle ScholarPubMed
Akompong, T, Ghori, N & Haldar, K (2000) In vitro activity of riboflavin against the human malaria parasite Plasmodium falciparum.. Antimicrobial Agents and Chemotherapy 44, 88–96CrossRefGoogle ScholarPubMed
Azas, N,Laurencin, N, Delmas, F, Di, GC,Gasquet, M, Laget, M & Timon-David, P (2002) Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali.. Parasitological Research 88, 165–171CrossRefGoogle ScholarPubMed
Balint, GA (2001) Antemisinin and its derivatives: an important new class of antimalarial agents.. Pharmacology and Therapeutics 90, 261–265CrossRefGoogle Scholar
Bringmann, G, Messer, K, Wolf, K, Muhlbacher, J, Grune, M,Brun, R & Louis, AM (2002) Dioncophylline E from Dioncophyllum thollonii, the first 7,3'-coupled dioncophyllaceous naphthylisoquinoline alkaloid.. Phytochemistry 60, 389–397CrossRefGoogle ScholarPubMed
Chan, AC, Chow, CK & Chiu, D (1999) Interaction of antioxidants and their implication in genetic anemia.. Proceedings of the Society for Experimental Biology and Medicine 222, 274–282CrossRefGoogle ScholarPubMed
Christen, P & Veuthey, JL (2001) New trends in extraction, identification and quantification of artemisinin and its derivatives.. Current Medicinal Chemistry 15, 1827–1839CrossRefGoogle Scholar
Destro-Bisol, G, D'Aloja, E, Spedini, G, Scatena, R, Giardina, B & Pascali, V (1999) Brief communication: resistance to Falciparum malaria in α-thalassemia, oxidative stress, and hemoglobin oxidation.. American Journal of Physical Anthropology 109, 269–2733.0.CO;2-#>CrossRefGoogle ScholarPubMed
Dhingra, V, Rao, KV & Narasu, ML (2000) Current status of artemisinin and its derivatives as antimalarial drugs.. Life Sciences 66, 279–300CrossRefGoogle ScholarPubMed
Dicke, M (2000) Chemical ecology of host–plant selection by herbivorous arthropods: a multitrophic perspective.. Biochemical Systematics and Ecology 28, 601–617CrossRefGoogle ScholarPubMed
do Ceu de Madureira, M, Paula Martins, A, Gomes, M, Paiva, J, Proenca da Cunha, A & Rosario, V (2002) Antimalarial activity of medicinal plants used in traditional medicine in S. Tome and Principe Islands.. Journal of Ethnopharmacology 81, 23–29CrossRefGoogle Scholar
Etkin, NL (1997) Plants as antimalarial drugs: relation to G6PD deficiency and evolutionary implications Adaptation to Malaria: The Interaction of Biology and Culture. 139–176 [ Greene, LS and Danubio, ME, editors ] New York: Gordon and Breach Publishers.Google Scholar
Etkin, NL Ross PJ (1997) Malaria, medicine and meals: a biobehavioral perspective. The Anthropology of Medicine 3rd ed. 169–209 [ Romanucci-Ross, L, Moerman, DE and Tancredi, LR, editors ] New York: Praeger PublishersGoogle Scholar
Frederich, M, Hayette, MP, Tits, M, De Mol, P & Angenot, L (2001) Reversal of chloroquine and mefloquine resistance in Plasmodium falciparum by the two monoindole alkaloids, icajine and isoretuline.. Planta Medica 67, 523–527CrossRefGoogle ScholarPubMed
Greene, LS (1997) Modification of antimalarial action of oxidants in traditional cuisines and medicines by nutrients which influence erythrocyte redox status Adaptation to Malaria: the Interaction of Biology and Culture, 139–176 [ Greene, LS and Danubio, ME, editors] New York: Gordon and Breach Publishers.Google Scholar
Greene, LS & Danubio, ME(editors) (1997) Adaptation to Malaria: the Interaction of Biology and Culture, New York: Gordon and Breach PublishersGoogle Scholar
Gupta, S, Thapar, MM, Wernsdorfer, WH & Bjorkman, A (2002) In vitro interactions of artemisinin with atovaquone, quinine, and mefloquine against Plasmodium falciparum.. Antimicrobial Agents and Chemotherapy 46, 1510–1515CrossRefGoogle ScholarPubMed
Harborne, JB (1993) Introduction to Ecological Biochemistry. 4th ed New York: Academic Press.Google Scholar
Hoffman, SL, Subramanian, GM, Collins, FH & Venter, JC (2002) Plasmodium, human and Anopheles genomics and malaria.. Nature 415, 702–709CrossRefGoogle ScholarPubMed
Howe, HF & Westley, LC (1988) Ecological Relationships of Plants and Animals, New York: Oxford University Press.Google Scholar
Johns, T (1996) The Origins of Human Diet and Medicine Tucson, AZ: University of Arizona Press.Google Scholar
Kemp, K, Akanmori, BD, Adabayeri, V, Goka, BQ, Kurtzhals, JA, Behr, C & Hviid, L (2002) Cytokine production and apoptosis among T cells from patients under treatment for Plasmodium falciparum malaria.. Clinical and Experimental Immunology 127, 151–157CrossRefGoogle ScholarPubMed
Kikuchi, H, Tasaka, H, Hirai, S, Takaya, Y, Iwabuchi, Y, Ooi, H, Hatakeyama, S, Kim, HS, Watays, Y & Oshima, Y (2002) Potent antimalarial febrifugine analogues against the plasmodium malaria parasite.. Journal of Medicinal Chemistry 45, 2563–2570CrossRefGoogle ScholarPubMed
Levander, OA & Ager, AL (1993) Malaria parasites and oxidantnutrients.. Parasitology 107 S95 – S106CrossRefGoogle Scholar
Li, Y & Wu, YL (1998) How Chinese scientists discovered quinghaosu (artemisinin) and developed its derivatives. What are the future perspectives?.. Medecine Tropicale: Revue du Corps De Santé Colonial 58, 9–12Google ScholarPubMed
Lin, WS, Chan, WCL & Hew, CS (1995) Superoxide and traditional Chinese medicines.. Journal of Ethnopharmacology 48, 165–171CrossRefGoogle ScholarPubMed
Najera, J (2001) Malaria control: achievements, problems and strategies.. Parassitologia 43, 1–89Google ScholarPubMed
Nosten, F & Brasseur, P (2002) Combination therapy for malaria: the way forward?.. Drugs 62, 1315–1329CrossRefGoogle ScholarPubMed
Pabon, A, Carmona, J, Maestre, A, Camargo, M & Blair, S (2002) Inhibition of P. falciparum by steroids from Solanum nudum.. Phytotherapy Research 16, 59–62CrossRefGoogle ScholarPubMed
Pradines, B, Fusai, T, Rogier, C, Keundjian, A, Sinou, V, Merckx, A, Mosnier, J, Daries, W, Torrentino, M & Parzy, D (2001) Prevention and treatment of malaria: in vitro evaluation of new compounds.. Annales Pharmaceutiques Francaise 59, 319–323Google ScholarPubMed
Prendergast, HDV, Etkin, NL, Harris, DR & Houghton, PJ (1998) Plants for Food and Medicine. Proceedings of the Joint Conference of the Society for Economic Botany and the International Society for Ethnopharmacology, London: London Royal Botanic GardenGoogle Scholar
Price, RN (2000) Artemisinin drugs: novel antimalarial agents.. Expert Opinion on Investigational Drugs 9, 1815–1827CrossRefGoogle ScholarPubMed
Rabinovich, NR (2002) Are we there yet? The road to a malaria vaccine.. Western Journal of Medicine 176, 82–84Google ScholarPubMed
Ruwende, C & Hill, A (1998) Review: Glucose-6-phosphate dehydrogenase deficiency and malaria.. Journal of Molecular Medicine 76, 581–588CrossRefGoogle ScholarPubMed
Schwartz, E, Samuni, A, Friedman, I, Hempelmann, E & Golenser, J (1999) The role of superoxide dismutation in malaria parasites.. Inflammation 23, 361–370Google ScholarPubMed
Scott, MD & Eaton, JW (1997) Parasite-mediated progeria: a possible mechanism for antimalarial action of G-6-PD deficient erythrocytes Adaptation to Malaria: the Interaction of Biology and Culture 89–102 [Greene, LS and Danubio, ME, editors ] New York: Gordon and Breach Publishers.Google Scholar
Shankar, AH (2000) Nutritional modulation of malaria morbidity and mortality.. Journal of Infectious Diseases 182 S37 – S52CrossRefGoogle ScholarPubMed
Taylor-Robinson, AW (2002) A model of development of acquired immunity to malaria in humans living under endemic conditions.. Medical Hypotheses 58, 148–156CrossRefGoogle Scholar
Tesoriere, L, D'Arpa, D, Butera, D, Allegra, M, Renda, D, Maggio, A, Bongiorno, A & Livrea, MA (2001) Oral supplements of vitamin E improve measures of oxidative stress in plasma and reduce oxidative damage to LDL and erythrocytes in beta-thalassemia intermedia patients.. Free Radical Research 34, 529–540CrossRefGoogle ScholarPubMed
Warhurst, DC (2002) Resistance to antifolates in Plasmodium falciparum, the causative agent of tropical malaria.. Science Progress 85, 89–111Google Scholar
Wildman, EC (2000) Handbook of Nutraceuticals and Functional Foods Boca Raton, FL: CRC PressGoogle Scholar