Hostname: page-component-6b989bf9dc-94dtm Total loading time: 0 Render date: 2024-04-14T17:53:05.886Z Has data issue: false hasContentIssue false

Disposition of lipids in the postprandial state

Published online by Cambridge University Press:  11 October 2007

Christine M. Williams
School of Biological Sciences, University of Surrey, Cuildford GU2 5XH
Rights & Permissions [Opens in a new window]


Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Principal Symposium on ‘Lipid absorption and metabolism: physiological and molecular aspects’
Copyright © The Nutrition Society 1996


Baldo, A., Sniderman, A. D., St-Luce, S., Avramoglu, R. K., Maslowska, M., Hoang, B., Monge, J. C., Bell, A., Mulay, S. & Cianffone, K. (1993). The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis. Journal of Clinical Investigation 92, 15431547.CrossRefGoogle ScholarPubMed
Baltzell, J. K., Wooten, J. T. & Otto, D. A. (1991). Lipoprotein lipase in rats fed fish oil: apparent relationship to plasma insulin levels. Lipids 26, 289294.CrossRefGoogle ScholarPubMed
Brown, A. J. & Roberts, D. C. K. (1991). Moderate fish oil intake improves lipemic response to a standard fat meal. A study in 25 healthy men. Arteriosclerosis and Thrombosis 11, 457466.CrossRefGoogle Scholar
Brunzell, J. D., Hazzard, W. R., Porte, D. & Bierman, E. L. (1973). Evidence for a common saturable removal mechanism for chylomicrons and very low density lipoproteins in man. Journal of Clinical Investigation 52, 15781585.CrossRefGoogle ScholarPubMed
Chen, Y.-D. I., Swami, S., Skowronski, R., Coulston, A. M. & Reaven, G. M. (1993). Differences in postprandial lipemia between patients with normal glucose tolerance and noninsulin dependent diabetes mellitus. Journal of Clinical Endocrinology and Metabolism 76, 172177.Google Scholar
Cianflone, K., Maslowska, M. H. & Sniderman, A. D. (1990). Impaired response of fibroblasts from patients with hyperapobetalipoproteinemia to acylation-stimulating protein. Journal of Clinical Investigation 85, 722730.CrossRefGoogle ScholarPubMed
Cianflone, K., Rodriguez, M., Walsh, M. J., Vu, H. & Sniderman, A. D. (1988). The effect of a plasma protein fraction on lipid synthesis in cultured skin fibroblasts from normals and patients with hyperbetalipo-proteinemia. Clinical Investigation and Medicine 11, 99107.Google Scholar
Cianflone, K., Vu, H., Baldo, W. B. & Sniderman, A. (1989b). Metabolic response of acylation stimulating protein to an oral fat load. Journal of Lipid Research 30, 17271733.CrossRefGoogle Scholar
Cianflone, K., Walsh, M. J., Vu, H., Gagnon, J., Sniderman, A. D. & Rodriguez, M. A. (1989a). Purification and characterisation of ASP. Journal of Biological Chemistry 265, 426430.Google Scholar
Cohn, J. S., Johnson, E. J., Millar, J. S., Cohn, S. D., Milne, R. W., Marcel, Y. L., Russell, R. M. & Schaefer, E. J. (1993). Contribution of apo B-48 and apo B-100 trigiyceride-rich lipoproteins (TRL) to postprandial increases in the plasma concentration of TRL triglycerides in retinyl esters. Journal of Lipid Research 34, 20332040.CrossRefGoogle ScholarPubMed
Cohn, J. S., McNamara, J. R., Cohn, S. D., Ordovas, J. M. & Schaefer, E. J. (1988b). Postprandial plasma lipoprotein changes in human subjects of different ages. Journal of Lipid Research 29, 469479.CrossRefGoogle ScholarPubMed
Cohn, J. S., Noakes, T. D. & Spinnler Benade, A. J. (1988a). Serum triglyceride responses to fatty meals: effects of meal fat content. American Journal of Clinical Nutrition 47, 825827.Google Scholar
Coppack, S. W., Evans, R. D., Fisher, R. M., Frayn, K. N., Gibbons, G. F., Humphreys, S. M., Kirk, M. L., Potts, J. L. & Hockaday, T. D. R. (1992). Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metabolism 41, 264272.CrossRefGoogle ScholarPubMed
Demacker, P. M. N., Reijnen, I. G. M., Katan, M. B., Stuyt, P. M. J. & Stalenhoef, A. F. H. (1991). Increased removal of remnants of triglyceride-rich Iipoproteins on a diet rich in polyunsaturated fatty acids. European Journal of Clinical Investigation 21, 197203.Google Scholar
Ebert, R., Nauck, M. & Creutzfeldt, W. (1991). Effect of exogenous and endogenous gastric inhibitory polypeptide (GIP) on plasma triglyceride responses in rats. Hormones and Metabolic Research 23, 517521.CrossRefGoogle ScholarPubMed
Eckel, R. H. (1989). Lipoprotein lipase-a multifunctional enzyme relevant to common metabolic diseases. New England Journal of Medicine 320, 10601068.Google Scholar
Eckel, R. H., Fujimoto, W. Y. & Brunzell, J. D. (1979). Gastroinhibitory polypeptide enhanced lipoprotein lipase activity in cultured preadipocytes. Diabetes 28, 11411142.CrossRefGoogle Scholar
Fielding, B. A., Owen, R., Callow, J. & Frayn, K. N. (1995). Origin of the early postprandial triacylglycerol peak. Proceedings of the Nutrition Society 54, 53A.Google Scholar
Frayn, K. N., Shahid, S., Hamlani, R., Humphreys, S. M., Clark, M. L., Fielding, B. A., Boland, O. & Coppack, S. W. (1994). Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition. American Journal of Physiology 266, E303E317.Google Scholar
Germinario, R., Sniderman, A. D., Manuel, S., Pratt, S., Baldo, A. & Cianflone, K. (1993). Coordinate response of triacylglycerol synthesis and glucose transport by acylation stimulating protein. Metabolism: Clinical and Experimental 42, 547580.CrossRefGoogle Scholar
Griffin, B. A. & Packard, C. J. (1994). Metabolism of VLDL and LDL sub-classes. Current Opinions in Lipidology 5, 200206.CrossRefGoogle Scholar
Griffiths, A. J., Humphreys, S. M., Clark, M. L., Fielding, B. A. & Frayn, K. N. (1994). Immediate metabolic availability of dietary fat in combination with carbohydrate. American Journal of Clinical Nutrition 59, 5359.CrossRefGoogle ScholarPubMed
Groot, P. H. E., de Boer, B. C. J., Haddemen, E., Houtsmuller, U. M. T. & Hulsmann, W. C. (1988). Effect of dietary fat composition on the metabolism of triacylglycerol-rich plasma Iipoproteins in the postprandial phase in meal fed rats. Journal of Lipid Research 29, 541551.CrossRefGoogle Scholar
Groot, P. H. E., Van Stiphout, W. A. H. J., Krauss, X. H., Jansen, H., Van Tol, A., Van Ramshorst, E., Chin-On, S., Hofman, A., Cresswell, S. R. & Havekes, L. (1991). Postprandial lipoprotein metabolism in normolipidemic men with and without Coronary Artery Disease. Arteriosclerosis and Thrombosis 11, 653662.Google Scholar
Harris, W. S., Connor, W. E., Alam, N. & Illingworth, D. R. (1988). Reduction of postprandial triglyceridemia in humans by dietary n-3 fatty acids. Journal of Lipid Research 29, 14511460.CrossRefGoogle ScholarPubMed
Harris, W. S. & Muzio, F. (1993). Fish oil reduces postprandial triglyceride concentrations without acceleiating lipid-emulsion removal rates. American Journal of Clinical Nutrition 58, 6874.CrossRefGoogle ScholarPubMed
Herzberg, G. R. & Rogerson, M. (1989). The effect of dietary fish oil on muscle and adipose tissue lipoprotein lipase. Lipids 24, 351353.CrossRefGoogle ScholarPubMed
Karpe, F., Olivecrona, T., Walldius, G. & Hamsten, A. (1992). Lipoprotein lipase in plasma after an oral fat load: relation to free fatty acids. Journal of Lipid Research 33, 975984.CrossRefGoogle ScholarPubMed
Karpe, F., Steiner, G., Olivecrona, T., Carlson, L. A. & Hamsten, A. (1993). Metabolism of triglyceride-rich lipoproteins during alimentary lipemia. Journal of Clinical Investigation 91, 748758.Google Scholar
Knapper, J. M. E., Puddicombe, S. M., Morgan, L. M., Fletcher, J. & Marks, V. (1995). Glucose dependent insulinotrophic polypeptide and glucagon-like peptide(7–36)amide: effects on Hpoprotein lipase activity. Journal of Nutrition 124, 183188.Google Scholar
Kwasowski, P., Flatt, P. R., Bailey, C. J. & Marks, V. (1985). Effect of fatty acid chain length and saturation on gastric inhibitory peptide release in obese hyperglycaemic (ob/ob) mice. Bioscience Reports 5, 701705.Google Scholar
Levy, E., Roy, C. C. R., Goldstein, R., Bar-On, H. & Ziv, E. Z. (1991). Metabolic fate of chylomicrons obtained from rats maintained on diets varying in fatty acid composition. Journal of American College of Nutrition 10, 6978.Google Scholar
Lewis, G. F., O'Meara, N. M., Solyts, P. A., Blackman, J. D., Iverius, P. H., Pugh, W. L., Getz, G. S. & Polonsky, K. S. (1991). Hypertriglyceridemia in non-insulin dependent diabetes mellitus is an important predictor of postprandial lipid and Hpoprotein abnormalities. Journal of Clinical Endocrinology and Metabolism 72, 934944.Google Scholar
Miller, G. J., Martin, C., Mitropoulos, K. A., Reeves, B. E. A., Thompson, R. L., Meade, T. W., Cooper, J. A. & Cruickshank, J. K. (1991). Plasma factor VII is activated by postprandial triglyceridaemia irrespective of dietary fat composition. Atherosclerosis 86, 163171.Google Scholar
Morgan, L. M., Hampton, S. M., Tredger, J. A., Cramb, R. & Marks, V. (1988a). Modifications of gastric inhibitory polypeptide (GIP) secretion in man by a high-fat diet. British Journal of Nutrition 59, 373380.Google Scholar
Morgan, L. M., Tredger, J. A., Hampton, S. M., French, A. P., Peake, J. C. F. & Marks, V. (1988b). The effect of dietary modification and hyperglycaemia on gastric emptyine and aastric inhibitory polypeptide (GIP) secretion. British Journal of Nutrition 60, 2937.Google Scholar
Murphy, M. C., Ishenvood, S. G., Sethi, S., Gould, B. J., Wright, J. W., Knapper, J. A. & Williams, C. M. (1995). Postprandial lipid and hormone responses to meals of varying fat contents: modulatory role of iipoprotein lipase?. European Journal of Clinical Nutrition 49, 579588.Google Scholar
Murphy, M. C., Zampeias, A., Puddicombe, S. M., Furlonger, N. P., Morgan, L. M. & Williams, C. M. (1993). Pre-translational regulation of the lipoprotein lipase gene by dietary fatty acids in the rat. British Journal of Nutrition 70, 727736.Google Scholar
Murthy, S., Albright, E., Mathur, S. N., Davidson, N. O. & Field, F. J. (1992). Apolipoprotein B mRNA abundance is decreased by eicosapentaenoic acid in CaCo-2 cells. Arteriosclerosis and Thrombosis 12, 691700.CrossRefGoogle ScholarPubMed
Nestel, P. J., Connor, W. E., Reardon, M. F., Connor, S., Wong, S. & Boston, R. (1984). Suppression by diets rich in fish oil of very low density Hpoprotein production in man. Journal of Clinical Investigation 74, 8289.CrossRefGoogle Scholar
Nilsson-Ehle, P., Garfinkel, A. & Schotz, M. C. (1980). Lipolytic enzymes and plasma Hpoprotein metabolism. Annual Reviews of Biochemistry 49, 667693.Google Scholar
Nozaki, S., Garg, A., Vega, G. L. & Grundy, S. M. (1991). Postheparin lipolytic activity and plasma Iipoprotein response to ω-3 polyunsaturated fatty acids in patients with primary hypertriglyceridemia. American Journal of Clinical Nutrition 53, 638642.Google Scholar
Olivecrona, T. & Bengsston-Olivecrona, G. (1990). Lipoprotein lipase and hepatic lipase. Current Opinions in Lipidology 1, 222230.Google Scholar
Patsch, J. R., Meisenbock, G., Hopferwieser, T., Muhlberger, V., Knall, E., Dunn, J. K., Gotto, A. M. & Patsch, W. (1992). Relation of triglyceride metabolism and coronary artery disease. Arteriosclerosis and Thrombosis 12, 13361345.Google Scholar
Peel, A. S., Zampeias, A., Williams, C. M. & Gould, B. J. (1993). A novel antiserum specific to apolipoprotein B-48: application in the investigation of postprandial lipidaemia in humans. Clinical Science 85, 521524.Google Scholar
Peterson, J., Bihain, B. E., Bengtsson-Olivecrona, G., Deckelbaum, R. J., Carpenter, Y. A. & Olivecrona, T. (1990). Fatty acid control of Iipoprotein lipase: A link between energy metabolism and lipid transport. Proceedings of the National Academy of Sciences, USA 87, 909913.Google Scholar
Potts, J. L., Fisher, R. M., Humphreys, S. M., Coppack, S. W., Gibbons, G. F. & Frayn, K. N. (1991). Peripheral triacylglycerol extraction in the fasting and post-prandial states. Clinical Science 81, 621626.Google Scholar
Ribeiro, A., Magneney, M., Cardot, P., Loriette, C., Rayssiguier, Y., Chambaz, J. & Bereziat, G. (1991). Effect of dietary fish oil and corn oil on lipid metabolism and apolipoprotein gene expression by rat liver. European Journal of Biochemistry 196, 499507.Google Scholar
Robinson, D. S. (1970). The function of plasma triglycerides in fatty acid transport. In Comprehensive Biochemistry. vol. 18, 51116 Florkin, M. & Stotz, E. H. Amsterdam: Elsevier.Google Scholar
Sadur, C. N. & Eckel, R. H. (1982). Insulin stimulation of adipose tissue lipoprotein lipase. Journal of Clinical Investigation 69, 11191125.Google Scholar
Saxena, U., Witte, L. D. & Goldberg, I. J. (1989). Release of endotheiial cell lipoprotein lipase by plasma lipoproteins and free fatty acids. Journal of Biological Chemistry 264, 43494355.CrossRefGoogle ScholarPubMed
Schneeman, B. O., Kotite, L., Todd, K. M. & Havel, R. J. (1993). Relationship between the responses of triglyceride-rich Iipoproteins in blood plasma containing apoiipoprotein B-48 and B-100 to a fat-containing meal in normolipidemic humans. Proceedings of the National Academy of Sciences, USA 90, 20692073.CrossRefGoogle ScholarPubMed
Sethi, S., Gibney, M. J. & Williams, C. M. (1993). Postprandial lipoprotein metabolism. Nutrition Research Reviews 6, 161183.Google Scholar
Simpson, H. S., Williamson, C. M., Olivecrona, T., Pringle, S., Maclean, J., Lorimer, A. R., Bonnefous, F., Bogaievsky, Y., Packard, C. J. & Shepherd, J. (1990). Postprandial lipemia, fenofibrate and Coronary Artery Disease. Atherosclerosis 85, 193202.Google Scholar
Syvanne, M., Vourinen-Markkola, H., Hilden, H. & Taskinen, M.-R. (1993). Gemfibrozil reduces postprandial lipemia in non-insulin dependent diabetes mellitus. Arteriosclerosis and Thrombosis 13, 286295.Google Scholar
Tan, K. C. B., Cooper, M. B., Ling, K. L. E., Griffin, B. A., Freeman, D. J., Packard, C. J., Shepherd, J., Hales, C. N. & Betteridge, D. J. (1995). Fasting and postprandial determinants for the occurrence of small dense LDL species in non-insulin dependent diabetic patients with and without hypertrighceridemia: the involvement of insulin, insulin precursor species and insulin resistance. Atherosclerosis 113, 273287.Google Scholar
Weintraub, M. S., Zechner, R., Brown, A., Eisenberg, S. & Breslow, J. L. (1988). Dietary polyunsaturated fats of the ω-6 and ω-3 series reduce postprandial lipoprotein levels. Journal of Clinical Investigation 82, 18841893.Google Scholar
Williams, C. M., Moore, F., Morgan, L. & Wright, J. (1992). Effects of n-3 fatty acids on postprandial triacylglycerol and hormone concentrations in normal subjects. British Journal of Nutrition 68, 655666.Google Scholar
Yasruel, Z. K., Cianflone, K., Sniderman, A. D., Rosenbloom, M., Walsh, M. & Rodriguez, M. A. (1991). Effect of acylation stimulating protein on the triacylglycerol synthetic pathway of human adipose tissue. Lipids 26, 495499.Google Scholar
Yki-Jarvinen, H., Taskinen, M.-R. & Koivisto, V. A. (1984). Response of adipose tissue lipoprotein lipase activity and serum Iipoproteins to acute hyperinsulinemia in man. Diabetoiogia 27, 364369.Google Scholar
Zampelas, A., Murphy, M. C., Morgan, L. M. & Williams, C. M. (1994). Postprandial lipoprotein lipase, insulin and gastric inhibitory polypeptide responses to test meals of different fatty acid composition: comparison of saturated, n-6 and n-3 polyunsaturated fatty acids. European Journal of Clinical Nutrition 48, 849858.Google Scholar