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Effects of micronutrient supplements on u.v.-induced skin damage

Published online by Cambridge University Press:  27 March 2009

M. J. Jackson ,
F. McArdle ,
A. Storey ,
S. A. Jones ,
A. McArdle  and
L. E. Rhodes
M. J. Jackson*
Affiliation:
Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK.
F. McArdle
Affiliation:
Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK.
A. Storey
Affiliation:
Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK.
S. A. Jones
Affiliation:
Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK.
A. McArdle
Affiliation:
Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK.
L. E. Rhodes
Affiliation:
Department of Medicine, University of Liverpool, Liverpool L69 3GA, UK.
*
*Professor M. J. Jackson, fax +44 151 706 5952, email mjj@liv.ac.uk.
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Abstract

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Development of an orally-administered systemic agent that could reduce the effects of u.v. exposure on skin could potentially have a major effect on the incidence of skin cancers and photo-ageing. A number of micronutrients have been suggested to have metabolic properties that could induce this protection, and our data indicate that n–3 polyunsaturated fatty acids are particularly effective in this role. The mechanisms of action of n–3 polyunsaturated fatty acids appear to depend on their anti-inflammatory properties, acting to reduce the u.v.-induced release of cytokines and other mediators from a variety of skin cell types.

Type
Symposium on ‘Micronutrient supplementation: is there a case?’
Information
Proceedings of the Nutrition Society , Volume 61 , Issue 2 , May 2002 , pp. 187 - 189
Copyright
Copyright © The Nutrition Society 2002

Footnotes

†

Present address: Department of Dermatology, University of Manchester, Hope Hospital, Manchester, UK.

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