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How dieting makes some fatter: from a perspective of human body composition autoregulation

  • Abdul G. Dulloo (a1), Jean Jacquet (a1) and Jean-Pierre Montani (a1)
Abstract

Dieting makes you fat – the title of a book published in 1983 – embodies the notion that dieting to control body weight predisposes the individual to acquire even more body fat. While this notion is controversial, its debate underscores the large gap that exists in our understanding of basic physiological laws that govern the regulation of human body composition. A striking example is the key role attributed to adipokines as feedback signals between adipose tissue depletion and compensatory increases in food intake. Yet, the relative importance of fat depletion per se as a determinant of post-dieting hyperphagia is unknown. On the other hand, the question of whether the depletion of lean tissues can provide feedback signals on the hunger–appetite drive is rarely invoked, despite evidence that food intake during growth is dominated by the impetus for lean tissue deposition, amidst proposals for the existence of protein–static mechanisms for the regulation of growth and maintenance of lean body mass. In fact, a feedback loop between fat depletion and food intake cannot explain why human subjects recovering from starvation continue to overeat well after body fat has been restored to pre-starvation values, thereby contributing to ‘fat overshooting’. In addressing the plausibility and mechanistic basis by which dieting may predispose to increased fatness, this paper integrates the results derived from re-analysis of classic longitudinal studies of human starvation and refeeding. These suggest that feedback signals from both fat and lean tissues contribute to recovering body weight through effects on energy intake and thermogenesis, and that a faster rate of fat recovery relative to lean tissue recovery is a central outcome of body composition autoregulation that drives fat overshooting. A main implication of these findings is that the risk of becoming fatter in response to dieting is greater in lean than in obese individuals.

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Corresponding author
* Corresponding author: Dr. Abdul G. Dulloo, fax +41 26 300 9734, email abdul.dulloo@unifr.ch
References
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1. Procope, J (1952) Hippocrates on Diet and Hygiene. London: Zeno.
2. Bacon, L & Aphramor, L (2011) Weight science: evaluating the evidence for a paradigm shift. Nutr J 10, 9.
3. National Institutes of Health Technology Assessment Conference Panel (1993) Methods for voluntary weight loss and control. Ann Intern Med 119, 764770.
4. Montani, JP, Viecelli, AK, Prévot, A et al. (2006) Weight cycling during growth and beyond as a risk factor for later cardiovascular diseases: the ‘repeated overshoot’ theory. Int J Obes 30, Suppl. 4, S58S66.
5. Kruger, J, Galuska, DA, Serdula, MK et al. (2004) Attempting to lose weight: specific practices among U.S. adults. Am J Prev Med 26, 402406.
6. Bendixen, H, Madsen, J, Bay-Hansen, D et al. (2002) An observational study of slimming behavior in Denmark in 1992 and 1998. Obes Res 10, 911922.
7. Lahti-Koski, M, Mannisto, S, Pietinen, P et al. (2005) Prevalence of weight cycling and its relation to health indicators in Finland. Obes Res 13, 333341.
8. Mann, T, Tomiyama, AJ, Westling, E et al. (2007) Medicare's search for effective obesity treatments: diets are not the answer. Am Psychol 62, 220233.
9. Cannon, G & Einzig, H (1983) Dieting Makes You Fat. London: Century Publishing.
10. National Task Force on the Prevention and Treatment of Obesity (1994) Weight cycling. JAMA 272, 11961202.
11. French, SA, Jeffery, RW, Forster, JL et al. (1994) Predictors of weight change over 2 years among a population of working adults; The Healthy Worker Project. Int J Obes 18, 145154.
12. Bild, DE, Sholinsky, P, Smith, DE et al. (1996) Correlates and predictors of weight loss in young adults: the CARDIA study. Int J Obes 20, 4755.
13. Coakley, EH, Rimm, EB, Colditz, G et al. (1998) Predictors of weight change in men: results from the Health Professionals Follow-up Study. Int J Obes 22, 8996.
14. McGuire, MT, Wing, RR, Hill, JO et al. (1999) What predicts weight gain in a group of successful weight losers? J Consult Clin Psychol 67, 177185.
15. Stice, E, Cameron, RP, Killen, JD et al. (1999) Naturalistic weight-reduction efforts prospectively predict growth in relative weight and onset of obesity among female adolescents. J Consult Clin Psychol 67, 967974.
16. Korkeila, M, Rissanen, A, Kaprio, J et al. (1999) Weight-loss attempts and risk of major weight gain: a prospective study in Finnish adults. Am J Clin Nutr 70, 965975.
17. Juhaeri, J, Stevens, J, Chambless, LE et al. (2001) Weight change among self-reported dieters and non-dieters in white and African American men and women. Eur J Epidemiol 17, 917923.
18. Kroke, A, Liese, AD, Schulz, M et al. (2002) Recent weight changes and weight cycling as predictors of subsequent two year weight change in a middle-aged cohort. Int J Obes 26, 403409.
19. Drapeau, V, Provencher, V, Lemieux, S et al. (2003) Do 6-y changes in eating behaviours predict changes in body weight? Results from the Quebec Family Study. Int J Obes 27, 808814.
20. Vogels, N, Diepvens, K & Westerterp-Plantenga, MS (2005) Predictors of long-term weight maintenance. Obes Res 13, 21622168.
21. Field, AE, Aneja, P, Austin, SB et al. (2007) Race and gender differences in the association of dieting and gains in BMI among young adults. Obesity 15, 456464.
22. Neumark-Sztainer, D, Wall, M, Haines, J et al. (2007) Why does dieting predict weight gain in adolescents? Findings from project EAT-II: a 5-year longitudinal study. J Am Diet Assoc 107, 448455.
23. Field, AE, Malspeis, S & Willett, WC (2009) Weight cycling and mortality among middle-aged or older women. Arch Intern Med 169, 881886.
24. Pietiläinen, KH, Saarni, SE, Kaprio, J et al. (2011) Does dieting make you fat? A twin study. Int J Obes 36, 456464.
25. Saarni, SE, Rissanen, A, Sarna, S et al. (2006) Weight cycling of athletes and subsequent weight gain in middleage. Int J Obes 30, 16391644.
26. Hill, AJ (2004) Does dieting make you fat? Br J Nutr 92, Suppl. 1, S15S18.
27. Lowe, MR & Timko, CA (2004) Dieting: really harmful, merely ineffective or actually helpful? Br J Nutr 92, Suppl. 1, S19S22.
28. Cannon, G (2005) Dieting. makes you fat? Br J Nutr 93, 569570.
29. Keski-Rahkonen, A, Neale, BM, Bulik, CM et al. (2005) Intentional weight loss in young adults: sex-specific genetic and environmental effects. Obes Res 13, 745753.
30. Dulloo, AG (1997) Human pattern of food intake and fuel-partitioning during weight recovery after starvation: a theory of autoregulation of body composition. Proc Nutr Soc 56, 2540.
31. Benedict, FG (1907) The influence of Inanition on Metabolism. Carnegie Institute of Washington Publication No. 77. Washington, DC: Carnegie Institute of Washington.
32. Benedict, FG, Miles, WR, Roth, P et al. (1919) Human Vitality and Efficiency under Prolonged restricted Diet. Carnegie Institute of Washington Publication No. 280. Washington, DC: Carnegie Institute of Washington.
33. Fleisch, A (1947) Ernährungsprobleme in Mangelzeiten (Nutritional Problems During Food Rationing) Basel: Benno Schwabe & Co.
34. Martin, E & Demole, M (1973) Une expérience scientifique d'alimentation controlée: le rationnement en Suisse pendant la deuxième guerre mondiale (A scientific experiment of controlled food intake: food rationing in Switzerland during World War II). In Régulation de l'Equilibre Energétique chez l'Homme , Vol. 1, pp. 185193 [Apfelbaum, M]. Paris: Masson.
35. Keys, A, Brozek, J, Henschel, A et al. (1950) The Biology of Human Starvation. Minnesota: University of Minnesota Press.
36. Nindl, BC, Friedl, KE, Frykman, PN et al. (1997) Physical performance and metabolic recovery among lean, healthy men following a prolonged energy deficit. Int J Sports Med 18, 317324.
37. Young, AJ, Castellani, JW, O'Brien, C et al. (1998) Exertional fatigue, sleep loss, and negative energy balance increase susceptibility to hypothermia. J Appl Physiol 85, 12101217.
38. Friedl, KE, Moore, RJ, Hoyt, RW et al. (2000) Endocrine markers of semistarvation in healthy lean men in a multistressor environment. J Appl Physiol 88, 18201830.
39. Polivy, J & Herman, CP (1985) Dieting and bingeing: a causal analysis. Am Psychol 40, 193201.
40. Dulloo, AG, Jacquet, J & Girardier, L (1996) Autoregulation of body composition during weight recovery in human: the Minnesota Experiment revisited. Int J Obes 20, 393405.
41. Dulloo, AG, Jacquet, J & Girardier, L (1997) Poststarvation hyperphagia and body fat overshooting in humans: a role for feedback signals from lean and fat tissues. Am J Clin Nutr 65, 717723.
42. Dulloo, AG & Jacquet, J (1998) Adaptive reduction in basal metabolic rate in response to food deprivation in humans: a role for feedback signals from fat stores. Am J Clin Nutr 68, 599606.
43. Dulloo, AG & Jacquet, J (1999) The control of partitioning between protein and fat during human starvation: its internal determinants and biological significance. Br J Nutr 82, 339356.
44. Dulloo, AG (1997) Regulation of body composition during weight recovery: integrating the control of energy partitioning and thermogenesis. Clin Nutr 16, Suppl. 1, 2535.
45. Payne, PR & Dugdale, AE (1977) Mechanisms for the control of body-weight. Lancet i, 583586.
46. Henry, CJ, Rivers, JP & Payne, PR (1988) Protein and energy metabolism in starvation reconsidered. Eur J Clin Nutr 42, 543549.
47. Passmore, R, Strong, JA & Ritchie, FJ (1958) The chemical composition of the tissue lost by obese patients on a reducing regimen. Br J Nutr 12, 113122.
48. Luke, A & Schoeller, DA (1992) Basal metabolic rate, fat-free mass, and body cell mass during energy restriction. Metabolism 41, 450456.
49. Major, GC, Doucet, E, Trayhurn, P et al. (2007) Clinical significance of adaptive thermogenesis. Int J Obes 31, 204212.
50. Rosenbaum, M, Hirsch, J, Gallagher, DA et al. (2008) Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr 88, 906912.
51. Dulloo, AG & Jacquet, J (2001) An adipose-specific control of thermogenesis in body weight regulation. Int J Obes 25, Suppl, 5, S22S29.
52. Carbonnel, F, Messing, B, Rimbert, A et al. (1997) Energy and protein metabolism during recovery from malnutrition due to nonneoplastic gastrointestinal disease. Am J Clin Nutr 65, 15171523.
53. Weyer, C, Walford, RL, Harper, IT et al. (2000) Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment. Am J Clin Nutr 72, 946953.
54. Kissileff, HR, Thornton, JC, Torres, MI et al. (2012) Leptin reverses declines in satiation in weight-reduced obese humans. Am J Clin Nutr 95, 309317.
55. Webster, AJ (1993) Energy partitioning, tissue growth and appetite control. Proc Nutr Soc 52, 6976.
56. Waterlow, J (1992) Protein Energy Malnutrition. London: Edward Arnold.
57. Millward, DJ (1995) A protein–stat mechanism for the regulation of growth and maintenance of the lean body mass. Nutr Res Rev 8, 93–120.
58. Blundell, JE, Caudwell, P, Gibbons, C et al. (2012) Body composition and appetite: fat-free mass (but not fat mass or BMI) is positively associated with self-determined meal size and daily energy intake in humans. Br J Nutr 107, 445449.
59. Trayhurn, P, Drevon, CA & Eckel, J (2011) Secreted proteins from adipose tissue and skeletal muscle – adipokines, myokines and adipose/muscle cross-talk. Arch Physiol Biochem 117, 4756.
60. Forbes, GB (1987) Lean body mass-body fat interrelationships in humans. Nutr Rev 45, 225231.
61. Wadden, TA, Foster, GD, Stunkard, AJ et al. (1996) Effects of weight cycling on the resting energy expenditure and body composition of obese women. Int J Eat Disord 19, 5–12.
62. Jebb, SA, Goldberg, GR, Coward, WA et al. (1991) Effects of weight cycling caused by intermittent dieting on metabolic rate and body composition in obese women. Int J Obes 15, 367374.
63. Dulloo, AG, Jacquet, J, Seydoux, J et al. (2006) The thrifty ‘catch-up fat’ phenotype: its impact on insulin sensitivity during growth trajectories to obesity and metabolic syndrome. Int J Obes 30, Suppl. 4, S23S35.
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