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A controlled evaluation of lithium prophylaxis in affective disorders

  • R. L. Cundall (a1), P. W. Brooks (a1) and L. G. Murray (a1)
  • DOI:
  • Published online: 01 July 2009

In a double-blind crossover trial lithium carbonate was found to be significantly superior to placebo in the prophylaxis of manic-depressive (bipolar) psychosis. A striking feature was the high incidence of manic or hypomanic attacks in patients who relapsed on placebo. Patients participated in the trial with their full knowledge and consent.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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