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Brain correlates of recognition of communicative interactions from biological motion in schizophrenia

Published online by Cambridge University Press:  27 November 2017

Ł. Okruszek*
Faculty of Psychology, University of Warsaw, Warsaw, Poland
M. Wordecha
Clinical Neuroscience Lab, Institute of Psychology, Polish Academy of Sciences, Warsaw, Poland
M. Jarkiewicz
Institute of Psychiatry and Neurology, Warsaw, Poland
B. Kossowski
Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
J. Lee
Department of Psychiatry & Biobehavioral Sciences, Semel Institute for Neuroscience and Human Behavior, UCLA, Los Angeles, CA, USA VA Greater Los Angeles Healthcare System, Los Angeles, CA, USA
A. Marchewka
Laboratory of Brain Imaging, Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warsaw, Poland
Author of correspondence: Ł. Okruszek, Email:



Recognition of communicative interactions is a complex social cognitive ability which is associated with a specific neural activity in healthy individuals. However, neural correlates of communicative interaction processing from whole-body motion have not been known in patients with schizophrenia (SCZ). Therefore, the current study aims to examine the neural activity associated with recognition of communicative interactions in SCZ by using displays of the dyadic interactions downgraded to minimalistic point-light presentations.


Twenty-six healthy controls (HC) and 25 SCZ were asked to judge whether two agents presented only by point-light displays were communicating or acting independently. Task-related activity and functional connectivity of brain structures were examined with General Linear Model and Generalized Psychophysiological Interaction approach, respectively.


HC were significantly more efficient in recognizing each type of action than SCZ. At the neural level, the activity of the right posterior superior temporal sulcus (pSTS) was observed to be higher in HC compared with SCZ for communicative v. individual action processing. Importantly, increased connectivity of the right pSTS with structures associated with mentalizing (left pSTS) and mirroring networks (left frontal areas) was observed in HC, but not in SCZ, during the presentation of social interactions.


Under-recruitment of the right pSTS, a structure known to have a pivotal role in social processing, may also be of importance for higher-order social cognitive deficits in SCZ. Furthermore, decreased task-related connectivity of the right pSTS may result in reduced use of additional sources of information (for instance motor resonance signals) during social cognitive processing in schizophrenia.

Original Articles
Copyright © Cambridge University Press 2017 

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Adams, R and David, AS (2007) Patterns of anterior cingulate activation in schizophrenia: a selective review. Neuropsychiatric Disease and Treatment 3, 87101.CrossRefGoogle ScholarPubMed
Backasch, B, Straube, B, Pyka, M, Klöhn-Saghatolislam, F, Müller, MJ, Kircher, TT and Leube, DT (2013) Hyperintentionality during automatic perception of naturalistic cooperative behavior in patients with schizophrenia. Social Neuroscience 8, 489504.CrossRefGoogle ScholarPubMed
Brett, M, Anton, J-L, Valabregue, R and Poline, J-B (2002) Region of interest analysis using the MarsBar toolbox for SPM 99. NeuroImage 16, S497.Google Scholar
Buckner, R, Krienen, F, Castellanos, A, Diaz, JC and Yeo, BT (2011) The organization of the human cerebellum estimated by intrinsic functional connectivity. Journal of Neurophysiology 106, 23222345.CrossRefGoogle ScholarPubMed
Centelles, L, Assaiante, C, Nazarian, B, Anton, JL and Schmitz, C (2011) Recruitment of both the mirror and the mentalizing networks when observing social interactions depicted by point-lights: a neuroimaging study. PloS ONE 6, e15749.CrossRefGoogle ScholarPubMed
Ciaramidaro, A, Becchio, C, Colle, L, Bara, BG and Walter, H (2014) Do you mean me? Communicative intentions recruit the mirror and the mentalizing system. Social Cognitive and Affective Neuroscience 9, 909916.CrossRefGoogle Scholar
Ciaramidaro, A, Bölte, S, Schlitt, S, Hainz, D, Poustka, F, Weber, B and Walter, H (2015) Schizophrenia and autism as contrasting minds: neural evidence for the hypo-hyper-intentionality hypothesis. Schizophrenia Bulletin 41, 171179.CrossRefGoogle ScholarPubMed
Das, P, Lagopoulos, J, Coulston, CM, Henderson, AF and Malhi, GS (2012) Mentalizing impairment in schizophrenia: a functional MRI study. Schizophrenia Research 134, 158164.CrossRefGoogle ScholarPubMed
Dasgupta, S, Tyler, SC, Wicks, J, Srinivasan, R and Grossman, ED (2016) Network connectivity of the right STS in three social perception localizers. Journal of Cognitive Neuroscience 29, 221234.CrossRefGoogle ScholarPubMed
Eskenazi, T, Rueschemeyer, SA, de Lange, FP, Knoblich, G and Sebanz, N (2015) Neural correlates of observing joint actions with shared intentions. Cortex 70, 90100.CrossRefGoogle ScholarPubMed
Frith, CD (2004) Schizophrenia and theory of mind. Psychological Medicine 34, 385389.CrossRefGoogle ScholarPubMed
Georgescu, AL, Kuzmanovic, B, Santos, NS, Tepest, R, Bente, G, Tittgemeyer, M and Vogeley, K (2014) Perceiving nonverbal behavior: neural correlates of processing movement fluency and contingency in dyadic interactions. Human Brain Mapping 35, 13621378.CrossRefGoogle ScholarPubMed
Green, MF, Horan, WP and Lee, J (2015) Social cognition in schizophrenia. Nature Reviews Neuroscience 16, 620631.CrossRefGoogle ScholarPubMed
Grosbras, MH, Beaton, S and Eickhoff, SB (2012) Brain regions involved in human movement perception: a quantitative voxel-based meta-analysis. Human Brain Mapping 33, 431454.CrossRefGoogle ScholarPubMed
Haxby, JV and Gobbini, MI (2011) Distributed neural systems for face perception. In Calder, A, Rhodes, G, Johnson, M, Johnson, M and Haxby, J (eds). Oxford Handbook of Face Perception. New York: Oxford University Press, pp. 93110.Google Scholar
Hoekert, M, Kahn, RS, Pijnenborg, M and Aleman, A (2007) Impaired recognition and expression of emotional prosody in schizophrenia: review and meta-analysis. Schizophrenia Research 96, 135145.CrossRefGoogle ScholarPubMed
Horan, WP, Iacoboni, M, Cross, KA, Korb, A, Lee, J, Nori, P and Green, MF (2014 a) Self-reported empathy and neural activity during action imitation and observation in schizophrenia. NeuroImage: Clinical 5, 100108.CrossRefGoogle Scholar
Horan, WP, Pineda, JA, Wynn, JK, Iacoboni, M and Green, MF (2014 b) Some markers of mirroring appear intact in schizophrenia: evidence from mu suppression. Cognitive, Affective, & Behavioral Neuroscience 14, 10491060.CrossRefGoogle ScholarPubMed
Jezzard, P and Balaban, RS (1995) Correction for geometric distortion in echo planar images from B0 field variations. Magnetic Resonance in Medicine 34, 6573.CrossRefGoogle ScholarPubMed
Johansson, G (1973) Visual perception of biological motion and a model for its analysis. Perception & Psychophysics 14, 201211.CrossRefGoogle Scholar
Kay, SR, Flszbein, A and Opfer, LA (1987) The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bulletin 13, 261.CrossRefGoogle Scholar
Kern, RS, Penn, DL, Lee, J, Horan, WP, Reise, SP, Ochsner, KN, Marder, SR and Green, MF (2013) Adapting social neuroscience measures for schizophrenia clinical trials, part 2: trolling the depths of psychometric properties. Schizophrenia Bulletin 39, 12011210.CrossRefGoogle ScholarPubMed
Kim, J, Park, S and Blake, R (2011) Perception of biological motion in schizophrenia and healthy individuals: a behavioral and FMRI study. PLoS ONE 6, e19971.Google ScholarPubMed
Kohler, CG, Walker, JB, Martin, EA, Healey, KM and Moberg, PJ (2009) Facial emotion perception in schizophrenia: a meta-analytic review. Schizophrenia Bulletin 36, 10091019.CrossRefGoogle ScholarPubMed
Kreifelts, B, Ethofer, T, Shiozawa, T, Grodd, W and Wildgruber, D (2009) Cerebral representation of non-verbal emotional perception: fMRI reveals audiovisual integration area between voice-and face-sensitive regions in the superior temporal sulcus. Neuropsychologia, 47, 30593066.CrossRefGoogle ScholarPubMed
Lee, H, Ku, J, Kim, J, Jang, DP, Yoon, KJ, Kim, SI. and Kim, JJ (2014) Aberrant neural responses to social rejection in patients with schizophrenia. Social Neuroscience 9, 412423.CrossRefGoogle ScholarPubMed
Li, H, Chan, RC, McAlonan, GM and Gong, QY (2010) Facial emotion processing in schizophrenia: a meta-analysis of functional neuroimaging data. Schizophrenia Bulletin, 36, 10291039.CrossRefGoogle ScholarPubMed
Mai, X, Zhang, W, Hu, X, Zhen, Z, Xu, Z, Zhang, J and Liu, C (2016) Using tDCS to explore the role of the right TPJ in theory of mind and cognitive empathy. Frontiers in Psychology 7, 380.CrossRefGoogle ScholarPubMed
Manera, V, Becchio, C, Schouten, B, Bara, BG and Verfaillie, K (2011) Communicative interactions improve visual detection of biological motion. PLoS ONE 6, e14594.CrossRefGoogle ScholarPubMed
Manera, V, Ianì, F, Bourgeois, J, Haman, M, Okruszek, ŁP, Rivera, SM, Robert, P, Schilbach, L, Sievers, E, Verfaillie, K, Vogeley, K, von der Lühe, T, Willems, S and Becchio, C (2015) The multilingual CID-5: a new tool to study the perception of communicative interactions in different languages. Frontiers in Psychology 6, 1724.CrossRefGoogle Scholar
Mier, D, Eisenacher, S, Rausch, F, Englisch, S, Gerchen, MF, Zamoscik, V, Meyer-Lindenberg, A, Zink, M and Kirsch, P (2016 Aberrant activity and connectivity of the posterior superior temporal sulcus during social cognition in schizophrenia. European Archives of Psychiatry and Clinical Neuroscience 267, 597610.CrossRefGoogle ScholarPubMed
Minzenberg, MJ, Laird, AR, Thelen, S, Carter, CS and Glahn, DC (2009) Meta-analysis of 41 functional neuroimaging studies of executive function in schizophrenia. Archives of General Psychiatry 66, 811822.CrossRefGoogle Scholar
Montag, C, Dziobek, I, Richter, IS, Neuhaus, K, Lehmann, A, Sylla, R, Heekeren, HR, Heinz, A and Gallinat, J (2011) Different aspects of theory of mind in paranoid schizophrenia: evidence from a video-based assessment. Psychiatry Research 186, 203209.CrossRefGoogle ScholarPubMed
Morosini, PL, Magliano, L, Brambilla, L, Ugolini, S and Pioli, R (2000) Development, reliability and acceptability of a new version of the DSM-IV Social and Occupational Functioning Assessment Scale (SOFAS) to assess routine social funtioning. Acta Psychiatrica Scandinavica 101, 323329.Google Scholar
Okruszek, Ł, Haman, M, Kalinowski, K, Talarowska, M, Becchio, C and Manera, V (2015) Impaired recognition of communicative interactions from biological motion in schizophrenia. PloS ONE 10, e0116793.CrossRefGoogle Scholar
Olbert, CM, Penn, DL, Kern, RS., Lee, J., Horan, WP., Reise, SP., Ochsner, K.N., Marder, S.R. and Green, M.F. (2013) Adapting social neuroscience measures for schizophrenia clinical trials, part 3: fathoming external validity. Schizophrenia Bulletin 39, 12111218.CrossRefGoogle ScholarPubMed
Quadflieg, S, Gentile, F and Rossion, B (2015) The neural basis of perceiving person interactions. Cortex 70, 520.CrossRefGoogle ScholarPubMed
Quadflieg, S and Koldewyn, K (2017) The neuroscience of people watching: how the human brain makes sense of other people's encounters. Annals of the New York Academy of Sciences 1396, 166182.CrossRefGoogle ScholarPubMed
Pica, P, Jackson, S, Blake, R and Troje, NF (2011) Comparing biological motion perception in two distinct human societies. PloS ONE 6, e28391.CrossRefGoogle ScholarPubMed
Reichenberg, A and Harvey, PD (2007) Neuropsychological impairments in schizophrenia: integration of performance-based and brain imaging findings. Psychological Bulletin 133, 833.CrossRefGoogle ScholarPubMed
Rocca, P, Galderisi, S, Rossi, A, Bertolino, A, Rucci, P, Gibertoni, D, Montemagni, C, Sigaudo, M, Mucci, A, Bucci, P, Acciavatti, T, Aguglia, E, Amore, M, Bellomo, A, De Ronchi, D, Dell'Osso, L, Di Fabio, F, Girardi, P, Goracci, A, Marchesi, C, Monteleone, P, Niolu, C, Pinna, F, Roncone, R, Sacchetti, E, Santonastaso, P, Zeppegno, P, Maj, M; Italian Network for Research on Psychoses (2016) Social cognition in people with schizophrenia: a cluster-analytic approach. Psychological Medicine 46, 2717.CrossRefGoogle ScholarPubMed
Russell, TA, Reynaud, E, Herba, C, Morris, R and Corcoran, R (2006) Do you see what I see? Interpretations of intentional movement in schizophrenia. Schizophrenia Research 81, 101111.CrossRefGoogle Scholar
Santiesteban, I, Banissy, MJ, Catmur, C and Bird, G (2012) Enhancing social ability by stimulating right temporoparietal junction. Current Biology 22, 22742277.CrossRefGoogle ScholarPubMed
Savla, GN, Vella, L, Armstrong, CC, Penn, DL and Twamley, EW (2012) Deficits in domains of social cognition in schizophrenia: a meta-analysis of the empirical evidence. Schizophrenia Bulletin 39, 979992.CrossRefGoogle ScholarPubMed
Saxe, R, Xiao, DK, Kovacs, G, Perrett, DI and Kanwisher, N (2004) A region of right posterior superior temporal sulcus responds to observed intentional actions. Neuropsychologia 42, 14351446.CrossRefGoogle ScholarPubMed
Scherzer, PB, Leveillé, E, Achim, A, Boisseau, E and Stip, E (2012) A study of theory of mind in paranoid schizophrenia: a theory or many theories?. Frontiers in Psychology 14, 432.Google Scholar
Schultz, J, Friston, KJ, O'Doherty, J, Wolpert, DM and Frith, CD (2005) Activation in posterior superior temporal sulcus parallels parameter inducing the percept of animacy. Neuron 45, 625635.CrossRefGoogle ScholarPubMed
Schurz, M, Radua, J, Aichhorn, M, Richlan, F and Perner, J (2014) Fractionating theory of mind: a meta-analysis of functional brain imaging studies. Neuroscience & Biobehavioral Reviews 42, 934.CrossRefGoogle ScholarPubMed
Sellaro, R, Nitsche, MA and Colzato, LS (2016) The stimulated social brain: effects of transcranial direct current stimulation on social cognition. Annals of the New York Academy of Sciences 1369, 218239.CrossRefGoogle ScholarPubMed
Shin, JE, Choi, SH, Lee, H, Shin, YS, Jang, DP and Kim, JJ (2015) Involvement of the dorsolateral prefrontal cortex and superior temporal sulcus in impaired social perception in schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry 58, 8188.CrossRefGoogle Scholar
Su, J, van Boxtel, JJ and Lu, H (2016) Social interactions receive priority to conscious perception. PloS ONE 10, e0160468.Google Scholar
Sugranyes, G, Kyriakopoulos, M, Corrigall, R, Taylor, E and Frangou, S (2011) Autism spectrum disorders and schizophrenia: meta-analysis of the neural correlates of social cognition. PloS ONE 6, e25322.CrossRefGoogle ScholarPubMed
Taylor, SF, Kang, J, Brege, IS, Tso, IF, Hosanagar, A and Johnson, TD (2012) Meta-analysis of functional neuroimaging studies of emotion perception and experience in schizophrenia. Biological Psychiatry 71, 136145.CrossRefGoogle Scholar
Van Overwalle, F, Baetens, K, Mariën, P and Vandekerckhove, M (2015 a) Cerebellar areas dedicated to social cognition? A comparison of meta-analytic and connectivity results. Social Neuroscience 10, 337344.Google ScholarPubMed
Van Overwalle, F, D'aes, T and Mariën, P (2015 b) Social cognition and the cerebellum: a meta-analytic connectivity analysis. Human Brain Mapping 36, 51375154.CrossRefGoogle ScholarPubMed
Van Overwalle, F and Mariën, P (2016) Functional connectivity between the cerebrum and cerebellum in social cognition: a multi-study analysis. NeuroImage 124, 248255.CrossRefGoogle ScholarPubMed
Vaskinn, A, Sundet, K, Østefjells, T, Nymo, K, Melle, I and Ueland, T (2016) Reading emotions from body movement: a generalized impairment in schizophrenia. Frontiers in Psychology 6, 2058.CrossRefGoogle Scholar
Vistoli, D, Brunet-Gouet, E, Lemoalle, A, Hardy-Baylé, MC and Passerieux, C (2011) Abnormal temporal and parietal magnetic activations during the early stages of theory of mind in schizophrenic patients. Social Neuroscience 6, 316326.CrossRefGoogle ScholarPubMed
Walter, H, Ciaramidaro, A, Adenzato, M, Vasic, N, Ardito, RB, Erk, S and Bara, BG (2009) Dysfunction of the social brain in schizophrenia is modulated by intention type: an fMRI study. Social Cognitive and Affective Neuroscience 4, 166176.CrossRefGoogle ScholarPubMed
White, TP, Borgan, F, Ralley, O and Shergill, SS (2016) You looking at me?: Interpreting social cues in schizophrenia. Psychological Medicine 46, 149160.CrossRefGoogle Scholar
Whitfield-Gabrieli, S and Nieto-Castanon, A (2012) CONN: a functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connectivity 2, 125141.CrossRefGoogle ScholarPubMed
World Health Organization (1992) The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Geneva: World Health Organization.Google Scholar
Yang, DY, Rosenblau, G, Keifer, C and Pelphrey, KA (2015) An integrative neural model of social perception, action observation, and theory of mind. Neuroscience & Biobehavioral Reviews 51, 263275.CrossRefGoogle ScholarPubMed
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