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Preliminary Communication Thyro-endocrine pathology, obstetric morbidity and schizophrenia: survey of a hundred families with a schizophrenic proband

Published online by Cambridge University Press:  09 July 2009

David MacSweeney*
MRC Neuropsychiatry Unit, Carshalton and West Park Hospital, Epsom, Surrey
Pauline Timms
MRC Neuropsychiatry Unit, Carshalton and West Park Hospital, Epsom, Surrey
Anthony Johnson
MRC Neuropsychiatry Unit, Carshalton and West Park Hospital, Epsom, Surrey
1Address for correspondence: Dr David MacSweeney, Academic Department of Psychiatry, Middlesex Hospital Medical School, London W1P 8AA.


This preliminary communication reports that the mothers of 104 schizophrenic patients had: (1) a significantly higher incidence of thyroid disease than a carefully matched control group; (2) significantly more abortions, still-births and greater infant mortality. The findings and possible relevance of thyroid disease to schizophrenia are discussed. Three prospective studies currently in progress are outlined.

Research Article
Copyright © Cambridge University Press 1978

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