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A case study of temporal lobe development in familial schizophrenia

Published online by Cambridge University Press:  09 July 2009

W. G. Honer ,
A. S. Bassett ,
P. Falkai ,
T. G. Beach  and
J. S. Lapointe
W. G. Honer*
Affiliation:
Departments of Psychiatry, Pathology and Radiology, University of British Columbia, Vancouver, BCDepartment of Psychiatry, University of Toronto, Ontario, Canada; Department of Psychiatry, University of Düsseldorf Germany
A. S. Bassett
Affiliation:
Departments of Psychiatry, Pathology and Radiology, University of British Columbia, Vancouver, BCDepartment of Psychiatry, University of Toronto, Ontario, Canada; Department of Psychiatry, University of Düsseldorf Germany
P. Falkai
Affiliation:
Departments of Psychiatry, Pathology and Radiology, University of British Columbia, Vancouver, BCDepartment of Psychiatry, University of Toronto, Ontario, Canada; Department of Psychiatry, University of Düsseldorf Germany
T. G. Beach
Affiliation:
Departments of Psychiatry, Pathology and Radiology, University of British Columbia, Vancouver, BCDepartment of Psychiatry, University of Toronto, Ontario, Canada; Department of Psychiatry, University of Düsseldorf Germany
J. S. Lapointe
Affiliation:
Departments of Psychiatry, Pathology and Radiology, University of British Columbia, Vancouver, BCDepartment of Psychiatry, University of Toronto, Ontario, Canada; Department of Psychiatry, University of Düsseldorf Germany
*
1Address for correspondence: Dr W. G. Honer, Department of Psychiatry. Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC. Canada V6H 3Z6.
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Synopsis

Case studies of patients with familial schizophrenia may help to define the pathophysiology of this illness and indicate potential candidate genes for genetic linkage studies. In this regard, the clinical, radiological and pathological assessments of a 39-year-old affected man from a pedigree with familial schizophrenia are presented. Brain imaging with CT indicated moderate cortical atrophy, particularly of the temporal lobes. Neuropathological examination revealed granular ependymitis, indicating possible past ventricular pathology. Granular ependymitis was reported to occur in genetic developmental disorders with neuronal migration abnormalities. In the present case, heterotopic clusters of neurons were visualized in the entorhinal cortex, suggesting that temporal lobe development was not entirely normal. This case study suggests that genetic factors could be investigated further as one possible aetiology of certain neurodevelopmental abnormalities observed in schizophrenia.

Type
Case Report
Information
Psychological Medicine , Volume 26 , Issue 1 , January 1996 , pp. 191 - 195
Copyright
Copyright © Cambridge University Press 1996

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References

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