Aker, Martin Bø, Ragnhild Harmer, Catherine Stiles, Tore C. and Landrø, Nils Inge 2016. Inhibition and response to error in remitted major depression. Psychiatry Research, Vol. 235, p. 116.
Allott, Kelly Fisher, Caroline A. Amminger, Gunther Paul Goodall, Joanne and Hetrick, Sarah 2016. Characterizing neurocognitive impairment in young people with major depression: state, trait, or scar?. Brain and Behavior, Vol. 6, Issue. 10, p. e00527.
Bora, Emre and Berk, Michael 2016. Theory of mind in major depressive disorder: A meta-analysis. Journal of Affective Disorders, Vol. 191, p. 49.
Bortolato, Beatrice Miskowiak, Kamilla W. Köhler, Cristiano A. Maes, Michael Fernandes, Brisa S. Berk, Michael and Carvalho, André F. 2016. Cognitive remission: a novel objective for the treatment of major depression?. BMC Medicine, Vol. 14, Issue. 1,
Brühl, Annette B. and Sahakian, Barbara J. 2016. Drugs, games, and devices for enhancing cognition: implications for work and society. Annals of the New York Academy of Sciences, Vol. 1369, Issue. 1, p. 195.
Brunoni, André Russowsky Tortella, Gabriel Benseñor, Isabela Martins Lotufo, Paulo Andrade Carvalho, André Ferrer and Fregni, Felipe 2016. Cognitive effects of transcranial direct current stimulation in depression: Results from the SELECT-TDCS trial and insights for further clinical trials. Journal of Affective Disorders, Vol. 202, p. 46.
Clark, Marci DiBenedetti, Dana and Perez, Vanessa 2016. Cognitive dysfunction and work productivity in major depressive disorder. Expert Review of Pharmacoeconomics & Outcomes Research, Vol. 16, Issue. 4, p. 455.
Depping, Malte S. Wolf, Nadine D. Vasic, Nenad Sambataro, Fabio Thomann, Philipp A. and Wolf, R. Christian 2016. Common and distinct structural network abnormalities in major depressive disorder and borderline personality disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 65, p. 127.
Griffiths, Kristi R. Lagopoulos, Jim Hermens, Daniel F. Lee, Rico S.C. Guastella, Adam J. Hickie, Ian B. and Balleine, Bernard W. 2016. Impaired causal awareness and associated cortical–basal ganglia structural changes in youth psychiatric disorders. NeuroImage: Clinical, Vol. 12, p. 285.
Hammar, Åsa Neto, Emanuel Clemo, Leila Hjetland, Gunnhild J. Hugdahl, Kenneth and Elliott, Rebecca 2016. Striatal hypoactivation and cognitive slowing in patients with partially remitted and remitted major depression. PsyCh Journal, Vol. 5, Issue. 3, p. 191.
Kandola, Aaron Hendrikse, Joshua Lucassen, Paul J. and Yücel, Murat 2016. Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment. Frontiers in Human Neuroscience, Vol. 10,
Kassel, Michelle T. Rao, Julia A. Walker, Sara J. Briceño, Emily M. Gabriel, Laura B. Weldon, Anne L. Avery, Erich T. Haase, Brennan D. Peciña, Marta Considine, Ciaran M. Noll, Douglas C. Bieliauskas, Linas A. Starkman, Monica N. Zubieta, Jon-Kar Welsh, Robert C. Giordani, Bruno Weisenbach, Sara L. and Langenecker, Scott A. 2016. Decreased Fronto-Limbic Activation and Disrupted Semantic-Cued List Learning in Major Depressive Disorder. Journal of the International Neuropsychological Society, Vol. 22, Issue. 04, p. 412.
Liu, Yansong Zhang, Fuquan Wang, Zhiqiang Cao, Leiming Wang, Jun Na, Aiguo Sun, Yujun and Zhao, Xudong 2016. Overgeneral autobiographical memory at baseline predicts depressive symptoms at follow-up in patients with first-episode depression. Psychiatry Research, Vol. 243, p. 123.
Mazereeuw, Graham Herrmann, Nathan Oh, Paul I. Ma, David W.L. Wang, Cheng Tao Kiss, Alexander and Lanctôt, Krista L. 2016. Omega-3 Fatty Acids, Depressive Symptoms, and Cognitive Performance in Patients With Coronary Artery Disease. Journal of Clinical Psychopharmacology, Vol. 36, Issue. 5, p. 436.
Miskowiak, K.W. Ott, C.V. Petersen, J.Z. and Kessing, L.V. 2016. Systematic review of randomized controlled trials of candidate treatments for cognitive impairment in depression and methodological challenges in the field. European Neuropsychopharmacology,
Miskowiak, K. W. Vinberg, M. Glerup, L. Paulson, O. B. Knudsen, G. M. Ehrenreich, H. Harmer, C. J. Kessing, L. V. Siebner, H. R. and Macoveanu, J. 2016. Neural correlates of improved executive function following erythropoietin treatment in mood disorders. Psychological Medicine, Vol. 46, Issue. 08, p. 1679.
Osuch, E. A. Manning, K. Hegele, R. A. Théberge, J. Neufeld, R. Mitchell, D. Williamson, P. and Gardner, R. C. 2016. Depression, marijuana use and early-onset marijuana use conferred unique effects on neural connectivity and cognition. Acta Psychiatrica Scandinavica, Vol. 134, Issue. 5, p. 399.
Ott, Caroline Vintergaard Bjertrup, Anne Juul Jensen, Johan Høy Ullum, Henrik Sjælland, René Purdon, Scot E. Vieta, Eduard Kessing, Lars V. and Miskowiak, Kamilla W. 2016. Screening for cognitive dysfunction in unipolar depression: Validation and evaluation of objective and subjective tools. Journal of Affective Disorders, Vol. 190, p. 607.
Otte, Christian Gold, Stefan M. Penninx, Brenda W. Pariante, Carmine M. Etkin, Amit Fava, Maurizio Mohr, David C. and Schatzberg, Alan F. 2016. Major depressive disorder. Nature Reviews Disease Primers, Vol. 2, p. 16065.
Pantzar, Alexandra Atti, Anna Rita Fratiglioni, Laura Fastbom, Johan Bäckman, Lars and Laukka, Erika J. 2016. Cognitive performance in unipolar old-age depression: a longitudinal study. International Journal of Geriatric Psychiatry,
There is evidence to suggest that cognitive deficits might persist beyond the acute stages of illness in major depressive disorder (MDD). However, the findings are somewhat inconsistent across the individual studies conducted to date. Our aim was to conduct a systematic review and meta-analysis of existing studies that have examined cognition in euthymic MDD patients.
Following a systematic search across several publication databases, meta-analyses were conducted for 27 empirical studies that compared euthymic adult MDD patients (895 participants) and healthy controls (997 participants) across a range of cognitive domains. The influence of demographic variables and confounding factors, including age of onset and recurrent episodes, was examined.
Compared with healthy controls, euthymic MDD patients were characterized by significantly poorer cognitive functions. However, the magnitude of observed deficits, with the exception of inhibitory control, were generally modest when late-onset cases were excuded. Late-onset cases demonstrated significantly more pronounced deficits in verbal memory, speed of information processing and some executive functions.
Cognitive deficits, especially poor response inhibition, are likely to be persistent features, at least of some forms, of adult-onset MDD. More studies are necessary to examine cognitive dysfunction in remitted psychotic, melancholic and bipolar spectrum MDD. Cognitive deficits overall appear to be more common among patients with late-onset depression, supporting the theories suggesting that possible vascular and neurodegenerative factors play a role in a substantial number of these patients.
This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
Email your librarian or administrator to recommend adding this journal to your organisation's collection.
Full text views reflects the number of PDF downloads, PDFs sent to Google Drive, Dropbox and Kindle and HTML full text views.
Abstract views reflect the number of visits to the article landing page.
* Views captured on Cambridge Core between September 2016 - 26th May 2017. This data will be updated every 24 hours.