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Depression and reduced natural killer cytotoxicity: a longitudinal study of depressed patients and control subjects

  • Michael Irwin (a1), Ute Lacher (a1) and Cindy Caldwell (a1)
  • DOI: http://dx.doi.org/10.1017/S0033291700038617
  • Published online: 01 July 2009
Abstract
Synopsis

Cross-sectional studies have demonstrated that natural killer (NK) cell activity is reduced in depression. To extend these observations and examine further the association between severity of depressive symptoms and values of NK activity, this study used a longitudinal case control design and assessed NK cytotoxicity at intake and at follow-up 6 months after discharge from the hospital in depressed patients and control subjects. From acute hospitalization to follow-up, depression scores significantly (P < 0·01) decreased following treatment in the depressed patients but did not change in the control subjects. NK activity significantly (P < 0·05) increased from intake to follow-up in the depressives while lytic activity did not change in the controls. At intake NK activity was significantly (P < 0·01) reduced in the depressed patients as compared to values in the controls, while at follow-up cytotoxicity was similar between the two groups. These longitudinal data suggest that a reduction of NK cytotoxicity is temporally associated with the state of acute depression.

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Corresponding author
1 Address for correspondence: Dr M. Irwin, Department of Psychiatry (V-116A), San Diego Veterans' Affairs Medical Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.
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R. Ader , D. Felten & N. Cohen (1990). Interactions between the brain and the immune system. In Annual Review of Pharmacology and Toxicology, vol. 30 (ed. R. George , A. K. Cho and T. F. Blaschke ). pp. 561602. Annual Reviews, Inc.: Palo Alto, CA.

C. A. Biron , K. S. Byron & J. L. Sullivan (1989). Severe herpes virus infections in an adolescent without natural killer cells. New England Journal of Medicine 320, 17311735.

J. F. Bukowski , J. F. Warner , G. Dennert & R. M. Welsh (1985). Adoptive transfer studies demonstrating the antiviral effect of natural killer cells in vivo. Journal of Experiment Medicine 161, 4052.

C. L. Caldwell , M. Irwin & J. Lohr (1991). Reduced natural killer cell cytoloxicity in depression but not in schizophrenia. Biological Psychiatry 30, 11311138.

J. Endicott & R. L. Spitzer (1978). A diagnostic interview: the Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry 35, 837841.

J. Endicott , J. Cohen , J. Nee , J. Fleiss & S. Sarantakos (1981). Hamilton Depression Rating Scale: extracted from regular and changed versions of the Schedule for Affective Disorders and Schizophrenia. Archives of General Psychiatry 38, 98103.

T.-K. Fu , L. F. Jarvik , F.-S. Yen & S. S. Matsuyama (1977). In vitro effects of imipramine on proliferation of human leukocytes. Archives of General Psychiatry 34, 728730.

R. Glaser , J. K. Kiecolt-Glaser , C. E. Speicher & J. E. Holliday (1985). Stress, loneliness and changes in herpes virus latency. Journal of Behavioral Medicine 8, 249260.

M. Irwin , T. L. Smith & J. C. Gillin (1987). Low natural killer cytotoxicity in major depression. Life Sciences 41, 21272133.

M. Irwin , C. Caldwell , T. L. Smith , S. Brown , M. A. Schuckit & J. C. Gillin (1990 a). Major depressive disorder, alcoholism, and reduced natural killer cytotoxicity: role of severity of depressive symptoms and alcohol consumption. Archives of General Psychiatry 47, 713719.

M. Irwin , T. Patterson , T. L. Smith , C. Caldwell , S. A. Brown , J. C. Gillin & I. Grant (1990 b). Reduction of immune function in life stress and depression. Biological Psychiatry 27, 2230.

M. E. Kemeny , L. Zegans & F. Cohen (1987). Stress, mood, immunity and recurrence of genital herpes. Annals of the New York Academy of Sciences 496, 735736.

J. L. Levenson , R. M. Hamer , T. Myers , R. P. Hart & L. G. Kaplowitz (1987). Psychological factors predict symptoms of severe recurrent genital herpes infection. Journal of Psychosomatic Research 31, 153159.

E. Lycke , R. Norbby & B. E. Roos (1974). A serological study on mentally ill patients. British Journal of Psychiatry 124, 273279.

M. Maes , W. Stevens , D. Peters , L. DeClerkck , S. Scharper , C. Bridts , C. Schotte & P. Cosyns (1992). A study on the blunted natural killer cell activity in severely depressed patients. Life Sciences (in the press).

D. Nerozzi , A. Santoni , G. Bersani , A. Magnani , A. Bressan , A. Passini , I. Antonozzi & G. Frajese (1989). Reduced natural killer cell activity in major depression: neuroendocrine implications. Psychoneuroendocrinology 14, 295302.

G. A. Padgett , C. W. Reiquam , J. B. Henson & J. R. Gorham (1968). Comparative studies of susceptibility to infection in the Chediak-Higashi syndrome. Journal of Pathology and Bacteriology 95, 509522.

H. F. Pross & V. A. Maroun (1984). The standardization of natural killer cell assays for use in studies of biological response modifiers. Journal of Immunological Methods 68, 235249.

J. Ritz (1989). The role of natural killer cells in immune surveillance. New England Journal of Medicine 320, 17481749.

S. J. Schleifer , S. E. Keller , R. N. Bond , J. Cohen & M. Stein (1989). Major depressive disorder and immunity. Archives of General Psychiatry 46, 8187.

M. Stein , A. H. Miller & R. L. Trestman (1991). Depression, the immune system, and health and illness. Archives of General Psychiatry 48, 171177.

J. L. Sullivan , K. S. Byron , F. E. Brewster & D. T. Purtilo (1980). Deficient natural killer activity in X-linked lymphoproliferative syndrome. Science 210, 535538.

A. Urch , C. H. Muller , H. Aschauer , F. Resch & C. C. Zielinski (1988). Lytic effector cell function in schizophrenia and depression. Journal of Neuroimmunology 18, 291301.

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Psychological Medicine
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