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Diminished recall and the cohort effect of major depression: a simulation study

  • Luis A. Giuffra (a1) and Neil Risch (a1)
  • DOI:
  • Published online: 01 July 2009

Several large-scale epidemiological surveys have reported increasing lifetime rates of psychopathology among recently born cohorts. In the case of Major Depressive Disorder (MDD) younger cohorts tend to manifest higher lifetime prevalences of the condition than older cohorts, at any given age. In some studies, cohort differences are so large that the youngest cohort exceeds the lifetime prevalence of the oldest cohort well before passing through their total period of risk. The data on lifetime prevalences that support the existence of secular differences, however, has typically been collected in cross-sectional studies. Thus, individuals are interviewed at a single point in time and asked to recall all prior psychopathology. Due to poor recall, this design may greatly underestimate earlier experiences. In fact, cohort differences are not limited to MDD; similar results have been reported for a wide range of psychopathology, suggesting methodological problems at data collection. We have conducted a simulation study to examine the magnitude of annual rates of forgetting that could produce the secular trends reported for MDD. Small, but constant annual rates produce striking, ‘cohort effect-like’ curves. The rates needed to reconstruct the reported effect are compatible with published values for test–retest studies of lifetime recall of MDD.

This simulation study does not rule out the existence of a cohort effect in some psychiatric disorders, but stresses the possible limitations of using cross-sectional studies to investigate secular trends.

Corresponding author
1 Address for correspondence: Dr Luis A. Giuffra, Department Psychiatry, Washington University School of Medicine, The Jewish Hospital of St Louis, 216, So. Kingshighway, St Louis, MO 63110, USA
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N. C. Andreasen , W. M. Grove , R. W. Shapiro , M. B. Keller , R. M. A. Hirschfeld & P. McDonald-Scott (1981). Reliability of lifetime diagnosis: a multicenter collaborative perspective. Archives of General Psychiatry 38, 400405.

N. C. Andreasen , J. Rice , J. Endicott , W. Coryell , W. M. Grove & T. Reich (1987). Familial rates of affective disorder: a report from the National Institute of Mental Health Collaborative Study. Archives of General Psychiatry 44, 461469.

C. S. Aneshensel , A. L. Estrada , M. J. Hansell & V. A. Clark (1987). Social psychological aspects of reporting behavior: lifetime depressive episode reports. Journal of Health and Social Behavior 28, 232246.

E. J. Bromet , L. O. Dunn , M. M. Connell , M. A. Dew & H. C. Schulberg (1986). Long-term reliability of dagnosing lifetime major depression in a community sample. Archives of General Psychiatry 43, 435440.

Cross-National Collaborative Group (1992). The changing rate of major depression: cross-national comparisons. Journal of the American Medical Association 268, 30983105.

E. S. Gershon , J. H. Hamovit , J. J. Guroff & J. I. Nurnberger (1987). Birth-cohort changes in manic and depressive disorders in relatives of bipolar and schizoaffective patients. Archives of General Psychiatry 44, 314319.

D. Hasin & B. Link (1988). Age and recognition of depression: implications for a cohort effect in major depression. Psychological Medicine 18, 683688.

G. L. Klerman (1988). The current age of youthful melancholia: evidence for increase in depression among adolescents and young adults. British Journal of Psychiatry 152, 414.

G. L. Klerman & M. M. Weissman (1989). Increasing rates of depression. Journal of the American Medical Association 261, 22292235.

G. L. Klerman , P. W. Lavori , J. Rice , T. Reich , J. Endicott , N. C. Andreasen , M. B. Keller & R. M. A. Hirschfield (1985). Birth-cohort trends in rates of major depressive disorder among relatives of patients with affective disorder. Archives of General Psychiatry 42, 689693.

M. Kramer , M. Von Korff & L. Kessler (1980). The lifetime prevalence of mental disorders: estimation, uses and limitations. Psychological Medicine 10, 429435.

K. Lasch , M. Weissman , P. Wickramaratne & M. L. Bruce (1990). Birth-cohort changes in the rates of mania. Psychiatry Research 33, 3137.

P. W. Lavori , G. L. Klerman , M. B. Keller , T. Reich , J. Rice & J. Endicott (1987). Age Period-Cohort analysis of secular trends in onset of major depression: findings in siblings of patients with major affective disorder. Journal of Psychiatric Research 21, 2335.

J. M. Murphy , A. M. Sobol , R. K. Neff , D. C. Olivier & A. H. Leighton (1984). Stability of prevalence: depression and anxiety disorders. Archives of General Psychiatry 41, 990997.

J. M. Murphy , R. R. Monson , D. C. Olivier , A. M. Sobol & A. H. Leighton (1987). Affective disorders and mortality: a general population study. Archives of General Psychiatry 44, 473480.

D. Pauls , L. Morton & J. Egeland (1992). Risk of affective illness among first-degree relatives of bipolar I Old Order Amish probands. Archives of General Psychiatry 49, 703708.

B. A. Prusoff , K. R. Merikangas & M. M. Weissman (1988). Lifetime prevalence and age of onset of psychiatric disorders: recall 4 years later. Journal of Psychiatric Research 22, 107117.

D. A. Regier , J. K. Myers , M. Kramer , L. N. Robins , D. G. Blazer , R. L. Hough , W. W. Eaton & B. Z. Locke (1984). The NIMH Epidemiologic Catchment Area program: historical context, major objectives, and study population characteristics. Archives of General Psychiatry 41, 934941.

T. Reich , C. R. Cloninger , P. Van Eerdewegh , J. P. Rice & J. Mullaney (1988). Secular trends in the familial transmission of alcoholism. Alcoholism: Clinical and Experimental Research 12, 458464.

J. P. Rice , N. Rochberg , J. Endicott , P. W. Lavori & C. Miller (1992). The stability of psychiatric diagnoses: an application to the affective disorders. Archives of General Psychiatry 49, 824830.

L. N. Robins , J. E. Helzer , M. M. Weissman , H. Orvaschel , E. Gruenberg , J. D. Burke & D. A. Regier (1984). Lifetime prevalence of specific psychiatric disorders in three sites. Archives of General Psychiatry 41, 949958.

R. H. Rogler , R. G. Malgady & W. W. Tryon (1992). Evaluation of Mental Health: Issues of memory in the Diagnostic Interview Schedule. Journal of Nervous and Mental Diseases 180, 215222.

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