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A developmental twin study of symptoms of anxiety and depression: evidence for genetic innovation and attenuation

  • K. S. Kendler (a1) (a2) (a3), C. O. Gardner (a1) (a2) and P. Lichtenstein (a4)
Abstract
Background

Little is known about the pattern of genetic and environmental influences on symptoms of anxiety and depression (SxAnxDep) from childhood to early adulthood.

Method

Parental- and self-reported levels of SxAnxDep were assessed at ages 8–9, 13–14, 16–17 and 19–20 years in 2508 twins from the Swedish Twin Study of Child and Adolescent Development (TCHAD). Analysis conducted using the Mx program included SxAnxDep by parental and self-report.

Results

The best-fit model revealed one genetic risk factor for SxAnxDep acting at ages 8–9, 13–14, 16–17 and 19–20, and new sets of genetic risk factors ‘coming on line’ in early adolescence, late adolescence and early adulthood. Together, these genetic factors were very strong influences on the levels of SxAnxDep reported in common by parents and twins with heritability estimates, correcting for rater- and time-specific effects, ranging from 72% to 89%. The first genetic factor, which accounted for 72% of the variance in SxAnxDep at ages 8–9, attenuated sharply in influence, accounting for only 12% of the variance by ages 19–20. No evidence was found for shared environmental influences. Although not statistically significant, the correlation between genetic risk factors for SxAnxDep in males and females declined with advancing age.

Conclusions

Genetic effects on SxAnxDep are developmentally dynamic from middle childhood to young adulthood, demonstrating both genetic innovation and genetic attenuation. The attenuation might explain the low levels of continuity observed for anxiety and depressive disorders from childhood to adulthood. Differences in genetic risk factors for SxAnxDep in males and females may increase during development.

Copyright
Corresponding author
*Address for correspondence: K. S. Kendler, M.D., Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA, USA. (Email: kendler@vcu.edu)
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

A Angold , EJ Costello (2006). Puberty and depression. Child and Adolescent Psychiatric Clinics of North America 15, 919937.

A Angold , EJ Costello , A Erkanli , CM Worthman (1999). Pubertal changes in hormone levels and depression in girls. Psychological Medicine 29, 10431053.

A Angold , EJ Costello , CM Worthman (1998). Puberty and depression: the roles of age, pubertal status and pubertal timing. Psychological Medicine 28, 5161.

DI Boomsma , CE van Beijsterveldt , JJ Hudziak (2005). Genetic and environmental influences on Anxious/Depression during childhood: a study from the Netherlands Twin Register. Genes, Brain and Behavior 4, 466481.

EJ Costello , HL Egger , A Angold (2005). The developmental epidemiology of anxiety disorders: phenomenology, prevalence, and comorbidity. Child and Adolescent Psychiatric Clinics of North America 14, 631648.

TC Eley , J Stevenson (1999). Exploring the covariation between anxiety and depression symptoms: a genetic analysis of the effects of age and sex. Journal of Child Psychology and Psychiatry 40, 12731282.

KS Kendler , CO Gardner , P Annas , MC Neale , LJ Eaves , P Lichtenstein (2008). A longitudinal twin study of fears from middle childhood to early adulthood: evidence for a developmentally dynamic genome. Archives of General Psychiatry 65, 421429.

KS Kendler , CO Gardner , MC Neale , CA Prescott (2001). Genetic risk factors for major depression in men and women: similar or different heritabilities and same or partly distinct genes? Psychological Medicine 31, 605616.

KS Kendler , A Heath , NG Martin , LJ Eaves (1986). Symptoms of anxiety and depression in a volunteer twin population. The etiologic role of genetic and environmental factors. Archives of General Psychiatry 43, 213221.

K Koshibu , P Levitt (2008). Gene×environment effects: stress and memory dysfunctions caused by stress and gonadal factor irregularities during puberty in control and TGF-alpha hypomorphic mice. Neuropsychopharmacology 33, 557565.

J Lasky-Su , HN Lyon , V Emilsson , IM Heid , C Molony , BA Raby , R Lazarus , B Klanderman , ME Soto-Quiros , L Avila , EK Silverman , G Thorleifsson , U Thorsteinsdottir , F Kronenberg , C Vollmert , T Illig , CS Fox , D Levy , N Laird , X Ding , MB McQueen , J Butler , K Ardlie , C Papoutsakis , G Dedoussis , CJ O'Donnell , HE Wichmann , JC Celedon , E Schadt , J Hirschhorn , ST Weiss , K Stefansson , C Lange (2008). On the replication of genetic associations: timing can be everything! American Journal of Human Genetics 82, 849858.

CG Last , S Perrin , M Hersen , AE Kazdin (1996). A prospective study of childhood anxiety disorders. Journal of the American Academy of Child and Adolescent Psychiatry 35, 15021510.

KE Markon , RF Krueger (2004). An empirical comparison of information-theoretic selection criteria for multivariate behavior genetic models. Behavioral Genetics 34, 593610.

TG O'Connor , JM Neiderhiser , D Reiss , EM Hetherington , R Plomin (1998). Genetic contributions to continuity, change, and co-occurrence of antisocial and depressive symptoms in adolescence. Journal of Child Psychology and Psychiatry 39, 323336.

G Schwarz (1978). Estimating the dimension of a model. Annual Statistics 6, 461464.

J Scourfield , F Rice , A Thapar , GT Harold , N Martin , P McGuffin (2003). Depressive symptoms in children and adolescents: changing aetiological influences with development. Journal of Child Psychology and Psychiatry and Allied Disciplines 44, 968976.

JL Silberg , M Rutter , L Eaves (2001). Genetic and environmental influences on the temporal association between earlier anxiety and later depression in girls. Biological Psychiatry 49, 10401049.

M Steiner , E Dunn , L Born (2003). Hormones and mood: from menarche to menopause and beyond. Journal of Affective Disorders 74, 6783.

A Thapar , P McGuffin (1994). A twin study of depressive symptoms in childhood. British Journal of Psychiatry 165, 259265.

TD Topolski , JK Hewitt , LJ Eaves , JL Silberg , JM Meyer , M Rutter , A Pickles , E Simonoff (1997). Genetic and environmental influences on child reports of manifest anxiety and symptoms of separation anxiety and overanxious disorders: a community-based twin study. Behavioral Genetics 27, 1528.

JM Twenge , S Nolen-Hoeksema (2002). Age, gender, race, socioeconomic status, and birth cohort differences on the children's depression inventory: a meta-analysis. Journal of Abnormal Psychology 111, 578588.

L Williams , P Holahan (1994). Parsimony-based fit indices for multiple-indicator models: do they work? Structural Equation Modeling 1, 161189.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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Supplementary Materials

Kendler Supplementary Material
Appendix.doc

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