Fryer, Susanna L Roach, Brian J Wiley, Katherine Loewy, Rachel L Ford, Judy M and Mathalon, Daniel H 2016. Reduced Amplitude of Low-Frequency Brain Oscillations in the Psychosis Risk Syndrome and Early Illness Schizophrenia. Neuropsychopharmacology, Vol. 41, Issue. 9, p. 2388.
Hu, Mao-Lin Zong, Xiao-Fen Zheng, Jun-Jie Pantazatos, Spiro P. Miller, Jeffrey M. Li, Zong-Chang Liao, Yan-Hui He, Ying Zhou, Jun Sang, De-En Zhao, Hong-Zeng Lv, Lu-Xian Tang, Jin-Song Mann, J. John and Chen, Xiao-Gang 2016. Short-term Effects of Risperidone Monotherapy on Spontaneous Brain Activity in First-episode Treatment-naïve Schizophrenia Patients: A Longitudinal fMRI Study. Scientific Reports, Vol. 6, p. 34287.
Kraguljac, Nina Vanessa White, David Matthew Hadley, Jennifer Ann Visscher, Kristina Knight, David ver Hoef, Lawrence Falola, Blessing and Lahti, Adrienne Carol 2016. Abnormalities in large scale functional networks in unmedicated patients with schizophrenia and effects of risperidone. NeuroImage: Clinical, Vol. 10, p. 146.
Lai, Chien-Han and Wu, Yu-Te 2016. The changes in the low-frequency fluctuations of cingulate cortex and postcentral gyrus in the treatment of panic disorder: The MRI study. The World Journal of Biological Psychiatry, Vol. 17, Issue. 1, p. 58.
Sheffield, Julia M. and Barch, Deanna M. 2016. Cognition and resting-state functional connectivity in schizophrenia. Neuroscience & Biobehavioral Reviews, Vol. 61, p. 108.
White, Thomas P Wigton, Rebekah Joyce, Dan W Collier, Tracy Fornito, Alex and Shergill, Sukhwinder S 2016. Dysfunctional Striatal Systems in Treatment-Resistant Schizophrenia. Neuropsychopharmacology, Vol. 41, Issue. 5, p. 1274.
Andreou, Christina Leicht, Gregor Nolte, Guido Polomac, Nenad Moritz, Steffen Karow, Anne Hanganu-Opatz, Ileana L. Engel, Andreas K. and Mulert, Christoph 2015. Resting-state theta-band connectivity and verbal memory in schizophrenia and in the high-risk state. Schizophrenia Research, Vol. 161, Issue. 2-3, p. 299.
Argyelan, Miklos Gallego, Juan A Robinson, Delbert G Ikuta, Toshikazu Sarpal, Deepak John, Majnu Kingsley, Peter B Kane, John Malhotra, Anil K and Szeszko, Philip R 2015. Abnormal Resting State fMRI Activity Predicts Processing Speed Deficits in First-Episode Psychosis. Neuropsychopharmacology, Vol. 40, Issue. 7, p. 1631.
Fryer, Susanna L Roach, Brian J Ford, Judith M Turner, Jessica A van Erp, Theo G M Voyvodic, James Preda, Adrian Belger, Aysenil Bustillo, Juan O'Leary, Daniel Mueller, Bryon A Lim, Kelvin O McEwen, Sarah C Calhoun, Vince D Diaz, Michelle Glover, Gary Greve, Douglas Wible, Cynthia G Vaidya, Jatin Potkin, Steven G and Mathalon, Daniel H 2015. Relating Intrinsic Low-Frequency BOLD Cortical Oscillations to Cognition in Schizophrenia. Neuropsychopharmacology, Vol. 40, Issue. 12, p. 2705.
Hsu, Shuo-En Chin Chen, Kao Lee, Lan-Ting Chun Tsai, Hsin Hui Lee, I See Chen, Po and Yang, Yen Kuang 2015. Comparison of cognitive deficits among drug-naive patients with schizophrenia and major depressive disorder. Journal of Affective Disorders, Vol. 175, p. 133.
Lai, Chien-Han and Wu, Yu-Te 2015. The patterns of fractional amplitude of low-frequency fluctuations in depression patients: The dissociation between temporal regions and fronto-parietal regions. Journal of Affective Disorders, Vol. 175, p. 441.
Lei, Wei Li, Mingli Deng, Wei Zhou, Yi Ma, Xiaohong Wang, Qiang Guo, Wanjun Li, Yinfei Jiang, Lijun Han, Yuanyuan Huang, Chaohua Hu, Xun and Li, Tao 2015. Sex-Specific Patterns of Aberrant Brain Function in First-Episode Treatment-Naive Patients with Schizophrenia. International Journal of Molecular Sciences, Vol. 16, Issue. 7, p. 16125.
Wu, Jiangfen Qian, Zhiyu Tao, Ling Yin, Jianhua Ding, Shangwen Zhang, Yameng and Yu, Zhou 2015. Resting state fMRI feature-based cerebral glioma grading by support vector machine. International Journal of Computer Assisted Radiology and Surgery, Vol. 10, Issue. 7, p. 1167.
Xu, Yongjie Zhuo, Chuanjun Qin, Wen Zhu, Jiajia and Yu, Chunshui 2015. Altered Spontaneous Brain Activity in Schizophrenia: A Meta-Analysis and a Large-Sample Study. BioMed Research International, Vol. 2015, p. 1.
Fatouros-Bergman, Helena Cervenka, Simon Flyckt, Lena Edman, Gunnar and Farde, Lars 2014. Meta-analysis of cognitive performance in drug-naïve patients with schizophrenia. Schizophrenia Research, Vol. 158, Issue. 1-3, p. 156.
Meda, S. A. Ruano, G. Windemuth, A. O'Neil, K. Berwise, C. Dunn, S. M. Boccaccio, L. E. Narayanan, B. Kocherla, M. Sprooten, E. Keshavan, M. S. Tamminga, C. A. Sweeney, J. A. Clementz, B. A. Calhoun, V. D. and Pearlson, G. D. 2014. Multivariate analysis reveals genetic associations of the resting default mode network in psychotic bipolar disorder and schizophrenia. Proceedings of the National Academy of Sciences, Vol. 111, Issue. 19, p. E2066.
Zhang, Fangfang Qiu, Linlin Yuan, Lili Ma, Huijuan Ye, Rong Yu, Fengqiong Hu, Panpan Dong, Yi and Wang, Kai 2014. Evidence for progressive brain abnormalities in early schizophrenia: A cross-sectional structural and functional connectivity study. Schizophrenia Research, Vol. 159, Issue. 1, p. 31.
Zhou, Yuan Wang, Zheng Zuo, Xi-Nian Zhang, Huiran Wang, Yun Jiang, Tianzi and Liu, Zhening 2014. Hyper-coupling between working memory task-evoked activations and amplitude of spontaneous fluctuations in first-episode schizophrenia. Schizophrenia Research, Vol. 159, Issue. 1, p. 80.
Given the important role of the default mode network (DMN) in cognitive function and the well-known neurocognitive deficit in schizophrenia, it is intriguing to examine systematically the relationship between neurocognitive dysfunction and aberrant intrinsic activities, and also functional connectivity, of the DMN in patients with schizophrenia.
First-episode, treatment-naive patients with schizophrenia (FES) (n = 115) and healthy controls (n = 113) underwent resting-state functional magnetic resonance imaging (fMRI) scans and neurocognitive tests. Intrinsic neural activities evaluated by using the fragment amplitude of low-frequency fluctuations (fALFF) and the resting-state functional connectivity assessed by seed-based correlational analysis were compared between patients and controls. Aberrant intrinsic activities and DMN connectivity in patients were then correlated to neurocognitive performance and clinical symptoms.
Compared to controls, patients with FES showed decreased fALFF in the bilateral medial prefrontal cortex (MPFC) and the orbitofrontal cortex (OFC), and increased fALFF in the bilateral putamen. Increased functional connectivity with the DMN was observed in the left insula and bilateral dorsolateral PFC (DLPFC) in patients with FES. In patients, aberrant fALFF in the bilateral OFC were correlated with cognitive processing speed; fALFF in the left OFC and right putamen were correlated with the clinical factors excited/activation and disorganization; and increased DMN functional connectivity in the left insula was correlated with the clinical factors positive, excited/activation, disorganization and neurocognitive deficit in the domain of sustained attention.
These associations between neurocognitive dysfunction and aberrant intrinsic activities, and also functional connectivity, of the DMN in patients with schizophrenia may provide important insights into the neural mechanism of the disease.
This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.
Email your librarian or administrator to recommend adding this journal to your organisation's collection.