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Developmental trajectories of psychotic-like experiences across adolescence: impact of victimization and substance use

  • C. J. Mackie (a1), N. Castellanos-Ryan (a1) and P. J. Conrod (a1)
Abstract
Background

Research suggests that psychotic-like experiences (PLEs) in the general population are common, but can reflect either transitory or persistent developmental phenomena. Using a general adolescent population it was examined whether different developmental subtypes of PLEs exist and whether different trajectories of PLEs are associated with certain environmental risk factors, such as victimization and substance use.

Method

Self-reported PLEs were collected from 409 adolescents (mean age 14 years 7 months) at four time points, each 6 months apart. General growth mixture modelling was utilized to identify classes of adolescents who followed distinct trajectories of PLEs across this period. Predictors of class membership included demographics, personality, victimization, depression, anxiety and substance use.

Results

We identified the following three developmental subgroups of PLEs: (1) persistent; (2) increasing; (3) low. Adolescents on the persistent trajectory reported frequent victimization and consistent elevated scores in depression and anxiety. Adolescents on the increasing trajectory were engaging in cigarette use prior to any increases in PLEs and were engaging in cocaine, cannabis and other drug use as PLEs increased at later time points.

Conclusions

The findings suggest that different developmental subgroups of PLEs exist in adolescence and are differentially related to victimization and substance use.

Copyright
Corresponding author
*Address for correspondence: Dr C. J. Mackie, Institute of Psychiatry, KCL, 4 Windsor Walk, LondonSE5 8AF, UK. (Email: clare.mackie@kcl.ac.uk)
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

H Akaike (1974). A new look at the statistical model identification. IEEE Transactions on Automatic Control 19, 616623.

L Arseneault , M Cannon , R Poulton , R Murray , A Caspi , TE Moffitt (2002). Cannabis use in adolescence and risk for adult psychosis: longitudinal prospective study. British Medical Journal 325, 12121213.

PE Bebbington , D Bhugra , T Brugha , N Singleton , M Farrell , R Jenkins , G Lewis , H Meltzer (2004). Psychosis, victimisation and childhood disadvantage. British Journal of Psychiatry 185, 220226.

M Camodeca , FA Goossens , C Schuengel , MM Terwogt (2003). Links between social information processing in middle childhood and involvement in bullying, Aggressive behavior 29, 116127.

MLC Campbell , AP Morrison (2007). The relationship between bullying, psychotic like experiences and appraisals in 14–16 year olds. Behaviour Research and Therapy 45, 15791591.

A Caspi , TE Moffitt , M Cannon , J McClay , R Murray , HL Harrington , A Taylor , L Arsenault , B Williams , A Braithwaite , R Poulton , IW Craig (2005). Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphorism in the catechol-o-methyltransferase gene: longitudinal evidence of a gene×environment interaction. Biological Psychiatry 57, 11171127.

D Collip , I Myin-Germeys , J van Os (2008). Does the concept of ‘sensitisation’ provide a plausible mechanism for the putative link between the environment and schizophrenia? Schizophrenia Bulletin 34, 220225.

P Conrod , N Castellanos , J Strang (2010) Brief personality-targeted coping skills interventions and survival as a nondrug user over a 2-year period during adolescence. Archives of General Psychiatry 67, 8593.

PJ Conrod , SH Stewart , N Comeau , AM Maclean (2006). Preventative efficacy of cognitive behavioral strategies matched to the motivational bases of alcohol misuse in at-risk youth. Journal of Clinical Child and Adolescent Psychology 35, 550563.



RF Ferdinand , J van der Ende , FC Verhulst (2004). Associations between visual and auditory hallucinations in children and adolescents, and tobacco use in adulthood. Social Psychiatry and Psychiatric Epidemiology 39, 514520.

DM Fergusson , LJ Horwood , NR Swain-Campbell (2003). Cannabis dependence and psychotic symptoms in young people. Psychological Medicine 33, 1521.



M Hanssen , M Bak , R Bijl , W Vollebergh , J van Os (2005). The incidence and outcome of subclinical psychotic experiences in the general population. British Journal of Clinical Psychology 44, 181191.

C Henquet , L Krabbendam , J Spauwen , C Kaplan , R Lieb , H-U Wittchen , J van Os (2005). Prospective cohort study of cannabis use, predisposition for psychosis, and psychotic symptoms in young people. British Medical Journal 330, 1114.

OD Howes , S Kapur (2009). The dopamine hypothesis of schizophrenia: version III – the final common pathway. Schizophrenia Bulletin 35, 549562.

I Janssen , L Krabbendam , M Bak , M Hanssen , W Vollebergh , R de Graaf , J van Os (2004). Childhood abuse as a risk factor for psychotic experiences. Acta Psychiatrica Scandinavica 109, 3845.

ND Kapusta , PL Plener , R Schmid , K Thau , H Walter , OM Lesch (2007). Multiple substance use among young males. Pharmacology, Biochemistry and Behavior 86, 306311.

I Kelleher , M Harley , F Lynch , L Arseneault , C Fitzpatrick , M Cannon (2008). Associations between childhood trauma, bullying and psychotic symptoms among a school-based adolescent sample. British Journal of Psychiatry 193, 378382.

L Krabbendam , J van Os (2005). Schizophrenia and urbanicity: a major environmental influence- conditional on genetic risk. Schizophrenia Bulletin 31, 795799.

T Lataster , I Myin-Germeys , C Derom , E Thiery , J van Os (2009). Evidence that self-reported psychotic experiences represent the transitory developmental expression of genetic liability to psychosis in the general population. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B, 10781084.

T Lataster , J van Os , M Drukker , C Henquet , F Feron , N Gunther , I Myin-Germeys (2006). Childhood victimisation and developmental expression of non-clinical delusional ideation and hallucinatory experiences. Social Psychiatry and Psychiatric Epidemiology 41, 423428.

KR Laurens , S Hodgins , B Maughan , RM Murray , ML Rutter , EA Taylor (2007). Community screening for psychotic-like experiences and other putative antecedents of schizophrenia in children aged 9–12 years. Schizophrenia Research 90, 130146.


YT Lo , NR Mendall , DB Rubin (2001). Testing the number of components in a normal mixture. Biometrika 88, 767778.

PE Meehl (1962). Schizotaxia, schizotypy, schizophrenia. American Psychologist 17, 827838.

C Morgan , H Fisher (2007). Environmental factors in schizophrenia: childhood trauma a critical review. Schizophrenia Bulletin 33, 3–10.

I Myin-Germeys , L Krabbendam , J Jolles , PA Delespaul , J van Os (2002) Are cognitive impairments associated with sensitivity to stress in schizophrenia? An experience sampling study. American Journal of Psychiatry 159, 443449.

I Myin-Germeys , J van Os (2007) Stress-reactivity in psychosis: evidence for an affective pathway to psychosis. Clinical Psychology Review 27, 409424.

I Myin-Germeys , J van Os , JE Schwartz , AA Stone , PA Delespaul (2001) Emotional reactivity to daily life stress in psychosis. Archives of General Psychiatry 58, 11371144.

M Olfson , R Lewis-Fernandez , MM Weissman , A Feder , MJ Gameroff , D Pilowsky , M Fuentes (2002). Psychotic symptoms in an urban general medicine practice American Journal of Psychiatry 159, 14121419.

R Poulton , A Caspi , TE Moffitt , M Cannon , RM Murray , HL Harrington (2000). Children's self reported psychotic symptoms and adult schizophreniform disorder. Archives of General Psychiatry 57, 10531058.

J Read , J van Os , AP Morrison , CA Ross (2005). Childhood trauma, psychosis and schizophrenia: a literature review with theoretical and clinical implications. Acta Psychiatrica Scandinavica 112, 330350.

A Schreier , D Wolke , K Thomas , J Horwood , C Hollis , D Gunnell , G Lewis , A Thompson , S Zammit , L Duffy , G Salvi , G Harrison (2009). Prospective study of peer victimization in childhood and psychotic symptoms in a nonclinical population at age 12 years. Archives of General Psychiatry 66, 527536.

G Schwartz (1978). Estimating the dimension of a model. Annual of Statistics 6, 461464.

J Scott , G Martin , W Bor , M Sawyer , J Clark , J McGrath (2009 a). The prevalence and correlates of hallucinations of Australian adolescents: results from a national survey. Schizophrenia Research 107, 179185.

J Scott , G Martin , J Welham , W Bor , J Najman , M O'Callaghan , G Williams , R Aird , J McGrath (2009 b). Psychopathology during childhood and adolescence predicts delusional-like experiences in adults: a 21-year birth cohort study. American Journal of Psychiatry 166, 567574.

DS Shaw , EF Wagner , J Arnett , MS Aber (1992). The factor structure of the Reckless Behavior Questionnaire. Journal of Youth Adolescence 21, 305323.

M Shevlin , MJ Dorahy , G Adamson (2007). Trauma and psychosis: an analysis of the National Comorbidity Survey. American Journal of Psychiatry 164, 166169.

TA Slotkin (2004). Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphates. Toxicology and Applied Pharmacology 198, 132151.

J Spauwen , L Krabbendam , R Lieb , H-U Wittchen , J van Os (2006). Impact of psychological trauma on the development of psychotic symptoms: relationship with psychosis proneness. British Journal of Psychiatry 188, 527533.

SI Tarbox , MF Pogue-Geile (2008). Development of social functioning in preschizophrenia children and adolescents: a systematic review. Psychological Bulletin 134, 561583.

J van Os , M Bak , M Hanssen , RV Biji , R de Graaf , H Verdoux (2002). Cannabis use and psychosis: a longitudinal population based study. American Journal of Epidemiology 156, 319327.

J van Os , M Hanssen , RV Bijl , A Ravelli (2000). Strauss (1969) revisited: a psychosis continuum in the general population? Schizophrenia Research 45, 1120.

R van Winkel , NC Stefanis , I Myin-Germeys (2008). Psychosocial stress and psychosis: review of the neurobiological mechanisms and the evidence for a gene stress interaction. Schizophrenia Bulletin 34, 10951105.

M Weiser , A Reichenberg , I Grotto , R Yasvitzky , J Rabinowitz , G Lubin , D Nahon , HY Knobler , M Davidson (2004). Higher rates of cigarette smoking in male adolescents before the onset of schizophrenia: a historical-prospective cohort study. American Journal of Psychiatry 161, 12191223.

NJ Wiles , S Zammit , P Bebbington , N Singleton , H Meltzer , G Lewis (2006). Self-reported psychotic symptoms in the general population: results from the longitudinal study of the British National Psychiatric Morbidity Survey. British Journal of Psychiatry 188, 519526.

P Woicik , S Stewart , RO Pihl , PJ Conrod (2009). The Substance Use Risk Profile Scale: a scale measuring traits linked to reinforcement-specific substance use profiles. Addictive behaviours 34, 10421055.

T Yoshizumi , S Murase , S Honjo , H Kaneko , T Murakami (2004). Hallucinatory experiences in a community sample of Japanese children. Journal of the American Academy of Child and Adolescent Psychiatry 43, 10301036.

S Zammit , P Allebeck , C Dalman , I Lundberg , T Hemmingsson , G Lewis (2003). Investigating the association between cigarette smoking and schizophrenia in a cohort study. American Journal of Psychiatry 160, 22162221.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
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