Bellou, Vanesa Belbasis, Lazaros Tzoulaki, Ioanna Evangelou, Evangelos and Ioannidis, John P.A. 2016. Environmental risk factors and Parkinson's disease: An umbrella review of meta-analyses. Parkinsonism & Related Disorders, Vol. 23, p. 1.
Belsky, Daniel W. 2016. Invited Commentary: Lessons for Research on Cognitive Aging From a Study of Children. American Journal of Epidemiology, Vol. 183, Issue. 12, p. 1083.
Biddle, Stuart 2016. Physical activity and mental health: evidence is growing. World Psychiatry, Vol. 15, Issue. 2, p. 176.
Brunner, Eric J. Welch, Catherine A. Shipley, Martin J. Ahmadi-Abhari, Sara Singh-Manoux, Archana and Kivimäki, Mika 2016. Midlife Risk Factors for Impaired Physical and Cognitive Functioning at Older Ages: A Cohort Study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, p. glw092.
Buford, Thomas W. 2016. Hypertension and aging. Ageing Research Reviews, Vol. 26, p. 96.
Cai, Yun and Abrahamson, Kathleen 2016. How Exercise Influences Cognitive Performance When Mild Cognitive Impairment Exists: A Literature Review. Journal of Psychosocial Nursing and Mental Health Services, Vol. 54, Issue. 1, p. 25.
Campos, Carlos Rocha, Nuno Barbosa F. Lattari, Eduardo Paes, Flávia Nardi, António E. and Machado, Sérgio 2016. Exercise-induced neuroprotective effects on neurodegenerative diseases: the key role of trophic factors. Expert Review of Neurotherapeutics, Vol. 16, Issue. 6, p. 723.
Carson, Valerie Hunter, Stephen Kuzik, Nicholas Wiebe, Sandra A. Spence, John C. Friedman, Alinda Tremblay, Mark S. Slater, Linda and Hinkley, Trina 2016. Systematic review of physical activity and cognitive development in early childhood. Journal of Science and Medicine in Sport, Vol. 19, Issue. 7, p. 573.
Cerajewska, T. L. Davies, M. and West, N. X. 2016. Periodontitis: a potential risk factor for Alzheimer's disease. BDJ Team, Vol. 3, Issue. 4, p. 16062.
Cheng, Sheung-Tak 2016. Cognitive Reserve and the Prevention of Dementia: the Role of Physical and Cognitive Activities. Current Psychiatry Reports, Vol. 18, Issue. 9,
D'Amico, Francesco Rehill, Amritpal Knapp, Martin Lowery, David Cerga-Pashoja, Arlinda Griffin, Mark Iliffe, Steve and Warner, James 2016. Cost-effectiveness of exercise as a therapy for behavioural and psychological symptoms of dementia within the EVIDEM-E randomised controlled trial. International Journal of Geriatric Psychiatry, Vol. 31, Issue. 6, p. 656.
de Guevara, Nicolás Mendoza Ladrón Galván, Carlos De Teresa Sánchez, Antonio Cano Izquierdo, Débora Godoy García, Fidel Hita Lapotka, Maryna Coto, Placido Llaneza Marqueta, Pedro Manonelles Amat, Antonio Martínez Hernández, Olga Ocón Alcalá, Laura Rodríguez Toral, Mercedes Vélez and Borrego, Rafael Sánchez 2016. Benefits of physical exercise in postmenopausal women. Maturitas,
Donnelly, Joseph E. Hillman, Charles H. Castelli, Darla Etnier, Jennifer L. Lee, Sarah Tomporowski, Phillip Lambourne, Kate and Szabo-Reed, Amanda N. 2016. Physical Activity, Fitness, Cognitive Function, and Academic Achievement in Children. Medicine & Science in Sports & Exercise, Vol. 48, Issue. 6, p. 1197.
Etnier, Jennifer L. Shih, Chia-Hao and Piepmeier, Aaron T. 2016. Exercise-Cognition Interaction.
Fowkes, Ross Byrne, Matthew Sinclair, Hannah Tang, Eugene and Kunadian, Vijay 2016. Coronary artery disease in patients with dementia. Coronary Artery Disease, Vol. 27, Issue. 6, p. 511.
Freudenberger, Paul Petrovic, Katja Sen, Abhijit Töglhofer, Anna Maria Fixa, André Hofer, Edith Perl, Sabine Zweiker, Robert Seshadri, Sudha Schmidt, Reinhold and Schmidt, Helena 2016. Fitness and cognition in the elderly. Neurology, Vol. 86, Issue. 5, p. 418.
Gajewski, Patrick D. and Falkenstein, Michael 2016. Physical activity and neurocognitive functioning in aging - a condensed updated review. European Review of Aging and Physical Activity, Vol. 13, Issue. 1,
Groot, C. Hooghiemstra, A.M. Raijmakers, P.G.H.M. van Berckel, B.N.M. Scheltens, P. Scherder, E.J.A. van der Flier, W.M. and Ossenkoppele, R. 2016. The effect of physical activity on cognitive function in patients with dementia: A meta-analysis of randomized control trials. Ageing Research Reviews, Vol. 25, p. 13.
Johnson, Nathan F. Gold, Brian T. Bailey, Alison L. Clasey, Jody L. Hakun, Jonathan G. White, Matthew Long, Doug E. and Powell, David K. 2016. Cardiorespiratory fitness modifies the relationship between myocardial function and cerebral blood flow in older adults. NeuroImage, Vol. 131, p. 126.
Kandola, Aaron Hendrikse, Joshua Lucassen, Paul J. and Yücel, Murat 2016. Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment. Frontiers in Human Neuroscience, Vol. 10,
The association between physical activity and risk of neurodegenerative diseases is not well established. We therefore aimed to quantify this association using meta-analytical techniques.
We searched Medline, the Cochrane Database of Systematic Reviews and Web of Science databases from 1990 to 2007 for prospective epidemiological studies of physical activity and incident dementia, Alzheimer's and Parkinson's disease. We excluded studies of physical activity and cognitive decline without diagnosis of a neurodegenerative disease. Information on study design, participant characteristics, measurement of exposure and outcome variables, adjustment for potential confounding, and estimates of associations was abstracted independently by the two investigators.
We included 16 prospective studies in the overall analysis, which incorporated 163797 non-demented participants at baseline with 3219 cases at follow-up. We calculated pooled relative risk (RR) using a random effects model. The RR of dementia in the highest physical activity category compared with the lowest was 0.72 [95% confidence interval (CI) 0.60–0.86, p<0.001], for Alzheimer's, 0.55 (95% CI 0.36–0.84, p=0.006), and for Parkinson's 0.82 (95% CI 0.57–1.18, p=0.28).
Our results suggest that physical activity is inversely associated with risk of dementia. Future studies should examine the optimal dose of physical activity to induce protection, which presently remains unclear.
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