Skip to main content
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 23
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Kontunen, Jarmo Timonen, Markku Muotka, Joona and Liukkonen, Timo 2016. Is interpersonal counselling (IPC) sufficient treatment for depression in primary care patients? A pilot study comparing IPC and interpersonal psychotherapy (IPT). Journal of Affective Disorders, Vol. 189, p. 89.

    Fonagy, Peter 2015. The effectiveness of psychodynamic psychotherapies: An update. World Psychiatry, Vol. 14, Issue. 2, p. 137.

    Zimmermann, Johannes Löffler-Stastka, Henriette Huber, Dorothea Klug, Günther Alhabbo, Sarah Bock, Astrid and Benecke, Cord 2015. Is It All about the Higher Dose? Why Psychoanalytic Therapy Is an Effective Treatment for Major Depression. Clinical Psychology & Psychotherapy, Vol. 22, Issue. 6, p. 469.

    Dekker, Jack J. M. Hendriksen, Mariëlle Kool, Simone Bakker, Laura Driessen, Ellen De Jonghe, Frans de Maat, Saskia Peen, Jaap and Van, Henricus L. 2014. Growing Evidence for Psychodynamic Therapy for Depression. Contemporary Psychoanalysis, Vol. 50, Issue. 1-2, p. 131.

    Hendriksen, Mariëlle Peen, Jaap Van, Rien Barber, Jacques P. and Dekker, Jack 2014. Is the alliance always a predictor of change in psychotherapy for depression?. Psychotherapy Research, Vol. 24, Issue. 2, p. 160.

    Park, Seon-Cheol Oh, Hong Seok Oh, Dong-Hoon Jung, Seung Ah Na, Kyoung-Sae Lee, Hwa-Young Kang, Ree-Hun Choi, Yun-Kyeung Lee, Min-Soo and Park, Yong Chon 2014. Evidence-Based, Non-Pharmacological Treatment Guideline for Depression in Korea. Journal of Korean Medical Science, Vol. 29, Issue. 1, p. 12.

    Cuijpers, Pim Huibers, Marcus Daniel Ebert, David Koole, Sander L. and Andersson, Gerhard 2013. How much psychotherapy is needed to treat depression? A metaregression analysis. Journal of Affective Disorders, Vol. 149, Issue. 1-3, p. 1.

    de Jonghe, Frans de Maat, Saskia Van, Rien Hendriksen, Marielle Kool, Simone van Aalst, Gerda and Dekker, Jack 2013. Short-Term Psychoanalytic Supportive Psychotherapy for Depressed Patients. Psychoanalytic Inquiry, Vol. 33, Issue. 6, p. 614.

    Dekker, Jack Van, Henricus L. Hendriksen, Mariëlle Koelen, Jurrijn Schoevers, Robert A. Kool, S. van Aalst, G. and Peen, Jaap 2013. What Is the Best Sequential Treatment Strategy in the Treatment of Depression? Adding Pharmacotherapy to Psychotherapy or Vice Versa?. Psychotherapy and Psychosomatics, Vol. 82, Issue. 2, p. 89.

    Dekker, Jack J.M. and Van, Rien 2012. Bona Fide or Non–Bona Fide?. The Journal of Nervous and Mental Disease, Vol. 200, Issue. 3, p. 274.

    Hendriksen, Mariëlle Van, Henricus L. Schoevers, Robert A. de Jonghe, Frans E.R.E.R. Gijsbers van Wijk, Cecile M.T. Peen, Jaap and Dekker, Jack J.M. 2011. Therapist Judgment of Defense Styles and Therapeutic Technique Related to Outcome in Psychodynamic Psychotherapy for Depression. Psychotherapy and Psychosomatics, Vol. 80, Issue. 6, p. 377.

    Koppers, D. Peen, J. Niekerken, S. Van, R. and Dekker, J. 2011. Prevalence and risk factors for recurrence of depression five years after short term psychodynamic therapy. Journal of Affective Disorders, Vol. 134, Issue. 1-3, p. 468.

    Molenaar, Pieter J. Boom, Yvette Peen, Jaap Schoevers, Robert A. Van, Rien and Dekker, Jack J. 2011. Is there a dose-effect relationship between the number of psychotherapy sessions and improvement of social functioning?. British Journal of Clinical Psychology, Vol. 50, Issue. 3, p. 268.

    Hendriksen, Mariëlle Van, Rien Peen, Jaap Oudejans, Suzan Schoevers, Robert and Dekker, Jack 2010. Psychometric properties of the Helping Alliance Questionnaire-I in psychodynamic psychotherapy for major depression. Psychotherapy Research, Vol. 20, Issue. 5, p. 589.

    Morriss, Richard K. and Scott, Jan 2009. Psychological management of mood disorders. Psychiatry, Vol. 8, Issue. 4, p. 108.

    Thase, Michael E. and Koenig, Aaron M. 2009. Depression.

    de Maat, Saskia Dekker, Jack Schoevers, Robert van Aalst, Gerda Gijsbers-van Wijk, Cecile Hendriksen, Marielle Kool, Simone Peen, Jaap Van, Rien and de Jonghe, Frans 2008. Short Psychodynamic Supportive Psychotherapy, antidepressants, and their combination in the treatment of major depression: a mega-analysis based on three Randomized Clinical Trials. Depression and Anxiety, Vol. 25, Issue. 7, p. 565.

    Dekker, J.J.M. Koelen, J.A. Van, H.L. Schoevers, R.A. Peen, J. Hendriksen, M. Kool, S. Van Aalst, G. and De Jonghe, F. 2008. Speed of action: The relative efficacy of short psychodynamic supportive psychotherapy and pharmacotherapy in the first 8 weeks of a treatment algorithm for depression. Journal of Affective Disorders, Vol. 109, Issue. 1-2, p. 183.

    Van, Henricus L. Schoevers, Robert A. Kool, Simone Hendriksen, Mariëlle Peen, Jaap and Dekker, Jack 2008. Does early response predict outcome in psychotherapy and combined therapy for major depression?. Journal of Affective Disorders, Vol. 105, Issue. 1-3, p. 261.

    Driessen, Ellen Van, Henricus L Schoevers, Robert A Cuijpers, Pim van Aalst, Gerda Don, Frank J Hendriksen, Mariëlle Kool, Simone Molenaar, Pieter J Peen, Jaap and Dekker, Jack JM 2007. Cognitive Behavioral Therapy versus Short Psychodynamic Supportive Psychotherapy in the outpatient treatment of depression: a randomized controlled trial. BMC Psychiatry, Vol. 7, Issue. 1,


Dose–effect relations in time-limited combined psycho-pharmacological treatment for depression

  • J. DEKKER (a1), P. J. MOLENAAR (a1), S. KOOL (a1), G. VAN AALST (a1), J. PEEN (a1) and F. de JONGHE (a1)
  • DOI:
  • Published online: 01 January 2005

Background. A limited number of psychotherapy sessions in combination with medication is preferable to pharmacotherapy only in the treatment of ambulatory patients with major depression. Whether there is a relation between the number of sessions and the efficacy of the treatment is uncertain.

Method. Randomized clinical trial comparing two treatment conditions in outpatients with major depression. All patients studied had a baseline score of at least 14 points on the 17-item Hamilton Depression Rating Scale. The two conditions consist of 8-session or 16-session Short Psychodynamic Supportive Psychotherapy, both in combination with pharmacotherapy. Efficacy was assessed using the 17-item HDRS, the CGI of Severity and of Improvement, the depression subscale of the SCL-90 and the Quality of Life Depression Scale.

Results. The rate of change would seem to indicate that eight sessions are preferable for both moderately and severely depressed patients, although the results converged again at the end. Furthermore, in terms of satisfaction with the number of sessions and drop-out percentages during treatment, no differences were found between the conditions.

Conclusion. In the light of the outcome analysis (faster remission after fewer sessions), a short version of the psychotherapy treatment in a combined course of treatment seems to be justified.

Corresponding author
Professor Dr J. Dekker, Vrije Universiteit, Amsterdam and Mentrum Mental Health Amsterdam, Klaprozenweg 111, Postbus 75848, 1070 AV Amsterdam, The Netherlands. (Email:
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *