Skip to main content
×
Home
    • Aa
    • Aa
  • Get access
    Check if you have access via personal or institutional login
  • Cited by 50
  • Cited by
    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Bremner, J. Douglas and Campanella, Carolina 2016. Posttraumatic Stress Disorder.


    Campanella, Carolina and Bremner, J. Douglas 2016. Posttraumatic Stress Disorder.


    Douglas Bremner, J. 2016. Developmental Psychopathology.


    Erford, Bradley T. Gunther, Chelsea Duncan, Kelly Bardhoshi, Gerta Dummett, Beth Kraft, Jennifer Deferio, Katie Falco, Michelle and Ross, Margaret 2016. Meta-Analysis of Counseling Outcomes for the Treatment of Posttraumatic Stress Disorder. Journal of Counseling & Development, Vol. 94, Issue. 1, p. 13.


    Helpman, Liat Papini, Santiago Chhetry, Binod T. Shvil, Erel Rubin, Mikael Sullivan, Gregory M. Markowitz, John C. Mann, J. John and Neria, Yuval 2016. PTSD REMISSION AFTER PROLONGED EXPOSURE TREATMENT IS ASSOCIATED WITH ANTERIOR CINGULATE CORTEX THINNING AND VOLUME REDUCTION. Depression and Anxiety, Vol. 33, Issue. 5, p. 384.


    Rubin, Mikael Shvil, Erel Papini, Santiago Chhetry, Binod T. Helpman, Liat Markowitz, John C. Mann, J. John and Neria, Yuval 2016. Greater hippocampal volume is associated with PTSD treatment response. Psychiatry Research: Neuroimaging, Vol. 252, p. 36.


    Saur, Lisiani Baptista, Pedro Porto Alegre Bagatini, Pamela Brambilla Neves, Laura Tartari de Oliveira, Raquel Mattos Vaz, Sabrina Pereira Ferreira, Kelly Machado, Susane Alves Mestriner, Régis Gemerasca and Xavier, Léder Leal 2016. Experimental Post-traumatic Stress Disorder Decreases Astrocyte Density and Changes Astrocytic Polarity in the CA1 Hippocampus of Male Rats. Neurochemical Research, Vol. 41, Issue. 4, p. 892.


    Stillman, Ashley N. and Aupperle, Robin L. 2016. Comprehensive Guide to Post-Traumatic Stress Disorders.


    Wu, Zhong-Min Yang, Li-Hua Cui, Rong Ni, Gui-Lian Wu, Feng-Tian and Liang, Yong 2016. Contribution of Hippocampal 5-HT3 Receptors in Hippocampal Autophagy and Extinction of Conditioned Fear Responses after a Single Prolonged Stress Exposure in Rats. Cellular and Molecular Neurobiology,


    Wu, Zhong-Min Zheng, Chun-Hua Zhu, Zhen-Hua Wu, Feng-Tian Ni, Gui-Lian and Liang, Yong 2016. SiRNA-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats. Journal of the Neurological Sciences, Vol. 360, p. 133.


    Kennis, Mitzy van Rooij, Sanne J H Tromp, Do P M Fox, Andrew S Rademaker, Arthur R Kahn, René S Kalin, Ned H and Geuze, Elbert 2015. Treatment Outcome-Related White Matter Differences in Veterans with Posttraumatic Stress Disorder. Neuropsychopharmacology, Vol. 40, Issue. 10, p. 2434.


    McCullough, Leslie Risley-Curtiss, Christina and Rorke, John 2015. Equine Facilitated Psychotherapy: A Pilot Study of Effect on Posttraumatic Stress Symptoms in Maltreated Youth. Journal of Infant, Child, and Adolescent Psychotherapy, Vol. 14, Issue. 2, p. 158.


    O'Doherty, Daniel C.M. Chitty, Kate M. Saddiqui, Sonia Bennett, Maxwell R. and Lagopoulos, Jim 2015. A systematic review and meta-analysis of magnetic resonance imaging measurement of structural volumes in posttraumatic stress disorder. Psychiatry Research: Neuroimaging, Vol. 232, Issue. 1, p. 1.


    Pagani, Marco Di Lorenzo, Giorgio Monaco, Leonardo Daverio, Andrea Giannoudas, Ioannis La Porta, Patrizia Verardo, Anna R. Niolu, Cinzia Fernandez, Isabel and Siracusano, Alberto 2015. Neurobiological response to EMDR therapy in clients with different psychological traumas. Frontiers in Psychology, Vol. 6,


    Riem, Madelon M. E. Alink, Lenneke R. A. Out, Dorothée Van Ijzendoorn, Marinus H. and Bakermans-Kranenburg, Marian J. 2015. Beating the brain about abuse: Empirical and meta-analytic studies of the association between maltreatment and hippocampal volume across childhood and adolescence. Development and Psychopathology, Vol. 27, Issue. 02, p. 507.


    Veer, Ilya M. Oei, Nicole Y.L. van Buchem, Mark A. Spinhoven, Philip Elzinga, Bernet M. and Rombouts, Serge A.R.B. 2015. Evidence for smaller right amygdala volumes in posttraumatic stress disorder following childhood trauma. Psychiatry Research: Neuroimaging, Vol. 233, Issue. 3, p. 436.


    Weingarten, Carol P. and Strauman, Timothy J. 2015. Neuroimaging for psychotherapy research: Current trends. Psychotherapy Research, Vol. 25, Issue. 2, p. 185.


    Yehuda, R. Pratchett, L. C. Elmes, M. W. Lehrner, A. Daskalakis, N. P. Koch, E. Makotkine, I. Flory, J. D. and Bierer, L. M. 2014. Glucocorticoid-related predictors and correlates of post-traumatic stress disorder treatment response in combat veterans. Interface Focus, Vol. 4, Issue. 5, p. 20140048.


    Gersons, Berthold P. R. and Schnyder, Ulrich 2013. Learning from traumatic experiences with brief eclectic psychotherapy for PTSD. European Journal of Psychotraumatology, Vol. 4,


    Levy-Gigi, Einat Szabó, Csilla Kelemen, Oguz and Kéri, Szabolcs 2013. Association Among Clinical Response, Hippocampal Volume, and FKBP5 Gene Expression in Individuals with Posttraumatic Stress Disorder Receiving Cognitive Behavioral Therapy. Biological Psychiatry, Vol. 74, Issue. 11, p. 793.


    ×

Effects of psychotherapy on hippocampal volume in out-patients with post-traumatic stress disorder: a MRI investigation

  • RAMÓN J. L. LINDAUER (a1) (a2) (a3), ERIK-JAN VLIEGER (a4), MARGJE JALINK (a1), MIRANDA OLFF (a1), INGRID V. E. CARLIER (a5), CHARLES B. L. M. MAJOIE (a4), GERARD J. DEN HEETEN (a4) and BERTHOLD P. R. GERSONS (a1)
  • DOI: http://dx.doi.org/10.1017/S0033291705005246
  • Published online: 01 October 2005
Abstract

Background. Magnetic resonance imaging (MRI) studies have especially reported smaller hippocampal volume in patients with post-traumatic stress disorder (PTSD), most of them war or sexual abuse victims. The present study compares the hippocampal volumes of out-patients with PTSD who had low co-morbidity rates to those of trauma-exposed control subjects without PTSD, and measures hippocampal volume changes in these patients after brief eclectic psychotherapy. We hypothesized that smaller hippocampal volumes are specific to PTSD and that hippocampal volume changes after effective psychotherapy would be measurable.

Method. Eighteen patients with PTSD and 14 traumatized control subjects were examined with MRI. In a randomized clinical trial, the PTSD patients were assigned to treatment (n=9) or waiting-list group (n=9). After the former received psychotherapy for 4 months, the MRI was repeated on both PTSD groups. Three temporal lobe structures were manually segmented: hippocampus, amygdala, and parahippocampal gyrus. Volumetric analysis was used to measure grey matter, white matter, and cerebrospinal fluid.

Results. PTSD patients had significantly smaller hippocampal volumes at baseline (total 13·8%, right 13·5%, left 14·1%) compared to the control subjects. After effective psychotherapy, however, no volume changes were found in the smaller hippocampi.

Conclusions. We confirmed previous findings of smaller hippocampal volume in PTSD in a new population made up of out-patients who experienced different types of traumas, reducing co-morbidity to a minimum. Smaller hippocampal volumes did not change after effective psychotherapy, even while symptoms resolved.

Copyright
Corresponding author
Academic Medical Centre, Department of Child and Adolescent Psychiatry, Tafelbergweg 25, 1105 BC Amsterdam, The Netherlands. [Email: R.J.Lindauer@amc.uva.nl (office) or RJL.Lindauer@12move.nl (home)]
Footnotes
Hide All
Presented at the Annual Meeting of the International Society for Traumatic Stress Studies, New Orleans, 16 November 2004, and at the European Congress for Psychotherapy, Amsterdam, 27 November 2004.
Footnotes
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×