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Extended psychosis phenotype – yes: single continuum – unlikely: A commentary on ‘Why we need more debate on whether psychotic symptoms lie on a continuum with normality’ by David (2010)

  • N. Kaymaz (a1) (a2) and J. van Os (a1) (a3)
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*Address for correspondence: J. van Os, Ph.D., Department of Psychiatry and Psychology, Maastricht University Medical Centre, PO Box 616 (location DOT12), 6200 MDMaastricht, The Netherlands. (Email:
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M Bak , I Myin-Germeys , M Hanssen , R Bijl , W Vollebergh , P Delespaul , J van Os (2003). When does experience of psychosis result in need for care? A prospective general population study. Schizophrenia Bulletin 29, 349358.

AS David (2010). Why we need more debate on whether psychotic symptoms lie on a continuum with normality. Psychological Medicine. Published online: 11 February 2010. doi: 10.1017/S0033291710000188.

M Hanssen , M Bak , R Bijl , W Vollebergh , J van Os (2005). The incidence and outcome of subclinical psychotic experiences in the general population. British Journal of Clinical Psychology 44, 181191.

OD Howes , S Kapur (2009). The dopamine hypothesis of schizophrenia: version III – the final common pathway. Schizophrenia Bulletin 35, 549562.

N Kaymaz , J van Os (2009 a). Heritability of structural brain traits: an endophenotype approach to deconstruct schizophrenia. International Review of Neurobiology 89, 85–130.

N Kaymaz , J van Os (2009 b). Murray et al. (2004) revisited: is bipolar disorder identical to schizophrenia without developmental impairment? Acta Psychiatrica Scandinavica 120, 249252.

RJ Linscott , J Van Os (2010). Systematic reviews of categorical versus continuum models in psychosis: evidence for discontinuous subpopulations underlying a psychometric continuum. Implications for DSM-V, DSM-VI, and DSM-VII. Annual Review of Clinical Psychology 6. Published online: 4 January 2010. doi: 10.1146/annurev.clinpsy.032408.153506.

RM Murray , P Sham , J Van Os , J Zanelli , M Cannon , C McDonald (2004). A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophrenia Research 71, 405416.

R Poulton , A Caspi , TE Moffitt , M Cannon , R Murray , H Harrington (2000). Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Archives of General Psychiatry 57, 10531058.

J Van Os , S Kapur (2009). Schizophrenia. Lancet 374, 635645.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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