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Extended psychosis phenotype – yes: single continuum – unlikely: A commentary on ‘Why we need more debate on whether psychotic symptoms lie on a continuum with normality’ by David (2010)

  • N. Kaymaz (a1) (a2) and J. van Os (a1) (a3)
Corresponding author
*Address for correspondence: J. van Os, Ph.D., Department of Psychiatry and Psychology, Maastricht University Medical Centre, PO Box 616 (location DOT12), 6200 MD Maastricht, The Netherlands. (Email:
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Bak M, Myin-Germeys I, Hanssen M, Bijl R, Vollebergh W, Delespaul P, van Os J (2003). When does experience of psychosis result in need for care? A prospective general population study. Schizophrenia Bulletin 29, 349358.
David AS (2010). Why we need more debate on whether psychotic symptoms lie on a continuum with normality. Psychological Medicine. Published online: 11 February 2010. doi: 10.1017/S0033291710000188.
Dominguez M, Can Saka M, Lieb R, Wittchen H-U, Van Os J (in press). Onset of clinical psychosis: do negative/disorganized symptoms increase risk for positive symptoms and for impairment? A 10-year study. American Journal of Psychiatry.
Dominguez MD, Wichers M, Lieb R, Wittchen HU, van Os J (2009). Evidence that onset of clinical psychosis is an outcome of progressively more persistent subclinical psychotic experiences: an 8-year cohort study. Schizophrenia Bulletin. Published online: 21 May 2009. doi: 10.1093/schbul/sbp022.
Hanssen M, Bak M, Bijl R, Vollebergh W, van Os J (2005). The incidence and outcome of subclinical psychotic experiences in the general population. British Journal of Clinical Psychology 44, 181191.
Howes OD, Kapur S (2009). The dopamine hypothesis of schizophrenia: version III – the final common pathway. Schizophrenia Bulletin 35, 549562.
Kaymaz N, van Os J (2009 a). Heritability of structural brain traits: an endophenotype approach to deconstruct schizophrenia. International Review of Neurobiology 89, 85–130.
Kaymaz N, van Os J (2009 b). Murray et al. (2004) revisited: is bipolar disorder identical to schizophrenia without developmental impairment? Acta Psychiatrica Scandinavica 120, 249252.
Linscott RJ, Van Os J (2010). Systematic reviews of categorical versus continuum models in psychosis: evidence for discontinuous subpopulations underlying a psychometric continuum. Implications for DSM-V, DSM-VI, and DSM-VII. Annual Review of Clinical Psychology 6. Published online: 4 January 2010. doi: 10.1146/annurev.clinpsy.032408.153506.
Murray RM, Sham P, Van Os J, Zanelli J, Cannon M, McDonald C (2004). A developmental model for similarities and dissimilarities between schizophrenia and bipolar disorder. Schizophrenia Research 71, 405416.
Picchioni MM, Walshe M, Toulopoulou T, McDonald C, Taylor M, Waters-Metenier S, Bramon E, Regojo A, Murray RM, Rijsdijk F (2009). Genetic modelling of childhood social development and personality in twins and siblings with schizophrenia. Psychological Medicine. Published online: 29 October 2009. doi: 10.1017/S0033291709991425.
Poulton R, Caspi A, Moffitt TE, Cannon M, Murray R, Harrington H (2000). Children's self-reported psychotic symptoms and adult schizophreniform disorder: a 15-year longitudinal study. Archives of General Psychiatry 57, 10531058.
Stip E, Letourneau G (2009). Psychotic symptoms as a continuum between normality and pathology. Canadian Journal of Psychiatry Revue Canadienne de Psychiatrie 54, 140151.
Van Os J, Kapur S (2009). Schizophrenia. Lancet 374, 635645.
Van Os J, Linscott RJ, Myin-Germeys I, Delespaul P, Krabbendam L (2009). A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness–persistence–impairment model of psychotic disorder. Psychological Medicine 39, 179195.
van Rossum I, Dominguez M, Lieb R, Wittchen H-U, van Os J (2009). Affective dysregulation and reality distortion: a 10-year prospective study of their association and clinical relevance. Schizophrenia Bulletin. Published online: 30 September 2009. doi: 10.1093/schbul/sbp101.
Welham J, Scott J, Williams G, Najman J, Bor W, O'Callaghan M, McGrath J (2008). Emotional and behavioural antecedents of young adults who screen positive for non-affective psychosis: a 21-year birth cohort study. Psychological Medicine 39, 625634.
Werbeloff N, Drukker M, Dohrenwend BP, Levav I, Yoffe R, Van Os J, Davidson M, Weiser M (2009). Self-reported psychotic symptoms in the community are associated with increased risk of later hospitalization for non-affective psychotic disorders (conference abstract). Schizophrenia Bulletin 35, 74.
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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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