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Factors influencing the occurrence of schizophrenia-like psychosis in patients with temporal lobe epilepsy

  • David C. Taylor (a1)


From a series of 255 patients who had undergone temporal lobectomy for the relief of intractable psychomotor epilepsy, all 47 patients with ‘alien tissue’ (small tumours, hamartomas, focal dysplasia) in the resected temporal lobe were contrasted with a group of 41 patients who showed mesial temporal sclerosis in their resected lobe. Five per cent of the mesial temporal sclerosis group and 23% of the alien tissue group were psychotic. A marked interaction occurred between psychosis and ‘left handedness’. In the alien tissue group, females, especially left-handed females, were the most likely to have developed a schizophrenia-like psychosis.



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Cavanagh, J. B. (1958). On certain small tumours encountered in the temporal lobe. Brain, 81, 389405.
Currie, S., Heathfield, K. W. G., Henson, R. A., and Scott, D. F. (1971). Clinical course and prognosis of temporal lobe epilepsy. A survey of 666 patients. Brain, 94, 173190.
Falconer, M. A. (1965). The surgical treatment of temporal lobe epilepsy. Neurochirurgia, 8, 161172.
Falconer, M. A. (1973). Reversibility by temporal-lobe resection of the behavioral abnormalities of temporal-lobe epilepsy. New England Journal of Medicine, 289, 451455.
Falconer, M. A., Hill, D., Meyer, A., Mitchell, W., and Pond, D. A. (1955). Treatment of temporal-lobe epilepsy by temporal lobectomy. A survey of findings and results. Lancet, 1, 827835.
Falconer, M. A., Serafetinides, E. A., and Corsellis, J. A. (1964). Etiology and pathogenesis of temporal lobe epilepsy. Archives of Neurology, 10, 233248.
Falconer, M. A., and Taylor, D. C. (1968). Surgical treatment of drug-resistant epilepsy due to mesial temporal sclerosis. Archives of Neurology, 19, 353361.
Flor-Henry, P. (1969). Psychosis and temporal lobe epilepsy. A controlled investigation. Epilepsia, 10, 363395.
Lancet (1974). Epilepsy, schizophrenia, and limbic system. Lancet, 2, 935936.
McLardy, T. (1969). Ammon's horn pathology and epileptic dyscontrol. Nature, 221, 877878.
Malamud, N. (1967). Psychiatric disorder with intracranial tumors of the limbric system. Archives of Neurology, 17, 113123.
Meldrum, B. S., and Brierley, J. B. (1972). Neuronal loss and gliosis in the hippocampus following repetitive epileptic seizures induced in adolescent baboons by allylglycine. Brain Research, 48, 361365.
Mignone, R. J., Donnelly, E. F., and Sadowsky, D. (1970). Psychological and neurological comparisons of psychomotor and non-psychomotor epileptic patients. Epilepsia, 11, 345359.
Satz, P. (1972). Pathological left-handedness: an explanatory model. Cortex, 8, 121135.
Serafetinides, E. A., and Falconer, M. A. (1962). The effects of temporal lobectomy in epileptic patients with psychosis. Journal of Mental Science, 108, 584593.
Slater, E., Beard, A. W., and Glithero, E. (1963). The schizophrenia-like psychoses of epilepsy. British Journal of Psvchiatry, 109, 95150.
Small, J. G., Milstein, V., and Stevens, J. R. (1962). Are psychomotor epileptics different? A controlled study. Archives of Neurology, 7, 187194.
Small, J. G., Small, I. F., and Hayden, M. P. (1966). Further psychiatric investigations of patients with temporal and nontemporal lobe epilepsy. American Journal of Psychiatry, 123, 303310.
Taylor, D. C. (1971). Ontogenesis of epileptic psychoses: a reanalysis. Psychological Medicine, 1, 247253.
Taylor, D. C. (1972). Mental state and temporal lobe epilepsy. A correlative account of 100 patients treated surgically. Epilepsia, 13, 727765.
Taylor, D. C., and Falconer, M. A. (1968). Clinical, socioeconomic, and psychological changes after temporal lobectomy for epilepsy. British Journal of Psychiatry, 114, 12471261.
Taylor, D. C., Falconer, M. A., Bruton, C. J., and Corsellis, J. A. N. (1971). Focal dysplasia of the cerebral cortex in epilepsy. Journal of Neurology, Neurosurgery, and Psychiatry, 34, 369387.

Factors influencing the occurrence of schizophrenia-like psychosis in patients with temporal lobe epilepsy

  • David C. Taylor (a1)


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