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Frontal and non-frontal lobe neuropsychological test performance and clinical symptomatology in schizophrenia

  • S. L. Morrison-Stewart (a1), P. C. Williamson (a1), W. C. Corning (a1), S. P. Kutcher (a1), W. G. Snow (a1) and H. Merskey (a1)...

Schizophrenic subjects performed significantly worse on neuropsychological tests of frontal lobe function but not on tests of non-frontal lobe function when compared to a matched group of normal subjects. Correlations expected between frontal lobe neuropsychological test performance and negative symptoms were not found.

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1Address for correspondence: Dr S. L. Morrison-Stewart, EEG Department, London Psychiatric Hospital, 850 Highbury Avenue, PO Box 2532, London, Ontario, Canada N6A 4H1.
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K. Berman , R. Zec & D. Weinberger (1986). Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. II. Role of neuroleptic treatment, attention and mental effort. Archives of General Psychiatry 43, 126135.

K. Berman , B. Illowsky & D. Weinberger (1988). Physiological dysfunction of the dorsolateral prefrontal cortex in schizophrenia. IV. Further evidence for regional and behavioral specificity. Archives of General Psychiatry 45, 616622.

R. A. Bornstein , H. A. Nasrallah , S. C. Olsen , J. A. Coffman , M. Torello & S. Schwarzkopf (1990). Neuropsychological deficit in schizophrenic subtypes: Paranoid, nonparanoid and schizo-affective subgroups. Psychiatry Research 31, 1524.

P. Bryden (1977). Measuring handedness with questionnaires. Neuropsychologia 15, 617624.

M. Buchsbaum & R. Haier (1987). Functional and anatomical brain imaging: impact on schizophrenia research. Schizophrenia Bulletin 13, 115132.

M. Buchsbaum , D. Ingvar , R. Kessler , R. Waters , J. Cappelletti , D. van Kammen , C. King , J. Johnson , R. Manning , R. Flynn , L. Mann , W. Bunney & L. Sokoloff (1982). Cerebral glucography with positron emission tomography: use in normal subjects and in patients with schizophrenia. Archives of General Psychiatry 39, 251259.

R. Cohen , W. Semple , M. Gross , T. Nordahl , L. DeLisi , H. Holcomb , A. King , J. Morihisa & D. Pickar (1987). Dysfunction in a prefrontal substrate of sustained attention in schizophrenia. Life Sciences 40, 20312039.

C. B. Dodrill (1981). An economical method for the evaluation of general intelligence in adults. Journal of Consulting and Clinical Psychology 49, 668673.

E. Goldberg (1985). Akinesia, tardive dysmentia and frontal lobe disorder in schizophrenia. Schizophrenia Bulletin 11, 255263.

J. Gruzelier , K. Seymour , L. Wilson , A. Jolly & S. Hirsch (1988). Impairments on neuropsychological tests of temporohippocampal and frontohippocampal functions and word fluency in remitting schizophrenia and affective disorders. Archives of General Psychiatry 45, 623629.

R. Gur , S. Resnick , R. Gur , A. Alavi , S. Caroff , M. Kushner & M. Revich (1987). Regional brain function in schizophrenia. II. Repeated evaluation with positron emission tomography. Archives of General Psychiatry 44, 126129.

M. Jones-Gotman & B. Milner , (1977). Design fluency: the invention of nonsense drawings after focal cortical lesions. Neuropsychologia 15, 635674.

J. Kear-Colwell (1973). The structure of the Wechsler Memory Scale and its relationship to ‘brain damage’. British Journal of Social and Clinical Psychology 12, 384392.

J. Keilp , J. Sweeney , P. Jacobsen , C. Solomon , L. St. Louis , M. Deck , A. Frances & J. Mann (1988). Cognitive impairment in schizophrenia: specific relations to ventricular size and negative symptomatology. Biological Psychiatry 24, 4755.

B. Kolb & I. Whishaw (1983). Performance of schizophrenic patients on tests sensitive to left or right frontal, temporal or parietal function in neurological patients. Journal of Nervous and Mental Disease 171, 435443.

B. Milner (1963). Effects of different brain lesions on card sorting. Archives of Neurology 9, 90100.

L. Seidman (1983). Schizophrenia and brain dysfunction: an integration of recent neurodiagnostic findings. Psychological Bulletin 94, 195238.

D. Weinberger (1987). Implications of normal brain development for the pathogenesis of schizophrenia. Archives of General Psychiatry 44, 660669.

D. Weinberger , K. Berman & R. Zec (1986). Physiologic dysfunction of dorsolateral prefrontal cortex in schizophrenia. I. Regional cerebral blood flow evidence. Archives of General Psychiatry 43, 114124.

D. Weinberger , K. Berman & B. Illowsky (1988). Physiological dysfunction of dorsolateral prefrontal cortex in schizophrenia. III. A new cohort and evidence for a monaminergic mechanism. Archives of General Psychiatry 45, 609615.

P. Williamson , S. Kutcher , P. Cooper , G. Snow , J. Szalai , H. Kaye , S. L. Morrison , R. Willinsky & M. Mamelak (1989). Psychological, topographic EEG, and CT scan correlates of frontal lobe function in schizophrenia. Psychiatry Research 29, 137149.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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