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    This article has been cited by the following publications. This list is generated based on data provided by CrossRef.

    Linszen, Mascha M.J. Brouwer, Rachel M. Heringa, Sophie M. and Sommer, Iris E. 2016. Increased risk of psychosis in patients with hearing impairment: Review and meta-analyses. Neuroscience & Biobehavioral Reviews, Vol. 62, p. 1.


    Gevonden, M. J. Myin-Germeys, I. van den Brink, W. van Os, J. Selten, J. P. and Booij, J. 2015. Psychotic reactions to daily life stress and dopamine function in people with severe hearing impairment. Psychological Medicine, Vol. 45, Issue. 08, p. 1665.


    Harper, Sarah Towers-Evans, Helen and MacCabe, James 2015. The aetiology of schizophrenia: what have the Swedish Medical Registers taught us?. Social Psychiatry and Psychiatric Epidemiology, Vol. 50, Issue. 10, p. 1471.


    Liu, Cindy H. Keshavan, Matcheri S. Tronick, Ed and Seidman, Larry J. 2015. Perinatal Risks and Childhood Premorbid Indicators of Later Psychosis: Next Steps for Early Psychosocial Interventions. Schizophrenia Bulletin, Vol. 41, Issue. 4, p. 801.


    Viertiö, Satu Perälä, Jonna Saarni, Samuli Koskinen, Seppo and Suvisaari, Jaana 2014. Hearing loss in persons with psychotic disorder—Findings from a population-based survey. Schizophrenia Research, Vol. 159, Issue. 2-3, p. 309.


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Hearing and speech impairment at age 4 and risk of later non-affective psychosis

  • A. Fors (a1), K. M. Abel (a2), S. Wicks (a1) (a3), C. Magnusson (a1) (a3) and C. Dalman (a1) (a3)
  • DOI: http://dx.doi.org/10.1017/S0033291712002644
  • Published online: 30 November 2012
Abstract
Background

Schizophrenia often becomes manifest in late adolescence and young adulthood but deviations in physical and behavioural development may already be present in childhood. We investigated the relationship between hearing impairment (measured with audiometry) and speech impairment (broadly defined) at age 4 years and adult risk of non-affective psychosis.

Method

We performed a population-based, case–control study in Sweden with 105 cases of schizophrenia or other non-affective psychoses and 213 controls matched for sex, date and place of birth. Information on hearing and speech impairment at age 4, along with potential confounding factors, was retrieved from Well Baby Clinic (WBC) records.

Results

Hearing impairment [odds ratio (OR) 6.0, 95% confidence interval (CI) 1.6–23.2] and speech impairment (OR 2.6, 95% CI 1.4–4.9) at age 4 were associated with an increased risk of non-affective psychotic illness. These associations were mutually independent and not explained by parental psychiatric history, occupational class or obstetric complications.

Conclusions

These results support the hypothesis that psychosis has a developmental aspect with presentation of antecedent markers early in childhood, long before the disease becomes manifest. Our findings add to the growing evidence that early hearing impairment and speech impairment are risk indicators for later non-affective psychosis and possibly represent aetiological clues and potentially modifiable risk factors. Notably, speech impairment and language impairment are both detectable with inexpensive, easily accessible screening.

Copyright
Corresponding author
*Address for correspondence: Dr A. Fors, Division of Public Health Epidemiology, Department of Public Health Sciences, Karolinska Institutet Norrbacka, 7th floor, SE-171 76 Stockholm, Sweden. (Email: annica.fors@sll.se)
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