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Letter to the Editor: Posttraumatic stress disorder has genetic overlap with cardiometabolic traits

  • J. A. Sumner (a1) (a2), L. E. Duncan (a3), E. J. Wolf (a4) (a5), A. B. Amstadter (a6), D. G. Baker (a7) (a8), J. C. Beckham (a9) (a10) (a11), B. Gelaye (a2), S. Hemmings (a12), N. A. Kimbrel (a9) (a10) (a11), M. W. Logue (a4) (a5), V. Michopoulos (a13), K. S. Mitchell (a4) (a5), C. Nievergelt (a7) (a8), A. Rothbaum (a14), S. Seedat (a12), G. Shinozaki (a15) and E. Vermetten (a16) (a17)...
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Abstract
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Corresponding author
*Address for correspondence: J. A. Sumner, Ph.D., Center for Behavioral Cardiovascular Health, Columbia University Medical Center, 622 W. 168th Street, PH 9-315, New York, NY 10032, USA. (Email: js4456@cumc.columbia.edu)
References
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Bulik-Sullivan, B, Finucane, HK, Anttila, V, Gusev, A, Day, FR, Loh, PR, ReproGen Consortium, Psychiatric Genomics Consortium, Genetic Consortium for Anorexia Nervosa of the Wellcome Trust Case Control Consortium, Duncan, L, Perry, JR, Patterson, N, Robinson, EB, Daly, MJ, Price, AL, Neale, BM (2015). An atlas of genetic correlations across human diseases and traits. Nature Genetics 47, 12361241.
Dedert, EA, Calhoun, PS, Watkins, LL, Sherwood, A, Beckham, JC (2010). Posttraumatic stress disorder, cardiovascular, and metabolic disease: a review of the evidence. Annals of Behavioral Medicine 39, 6178.
Dudbridge, F (2016). Polygenic epidemiology. Genetic Epidemiology 40, 268272.
Duncan, LE, Ratanatharathorn, A, Aiello, AE, Almli, LM, Amstadter, AB, Ashley-Koch, AE, Baker, DG, Beckham, JC, Bierut, LJ, Bisson, J, Bradley, B, Chen, CY, Dalvie, S, Farrer, LA, Galea, S, Garrett, ME, Gelernter, JE, Guffanti, G, Hauser, MA, Johnson, EO, Kessler, RC, Kimbrel, NA, King, A, Koen, N, Kranzler, HR, Logue, MW, Maihofer, AX, Martin, AR, Miller, MW, Morey, RA, Nugent, NR, Rice, JP, Ripke, S, Roberts, AL, Saccone, NL, Smoller, JW, Stein, DJ, Stein, MB, Sumner, JA, Uddin, M, Ursano, RJ, Wildman, DE, Yehuda, R, Zhao, H, Daly, MJ, Liberzon, I, Ressler, KJ, Nievergelt, CM, Koenen, KC (2017). Largest GWAS of PTSD (N=20,070) yields genetic overlap with schizophrenia and sex differences in heritability. Molecular Psychiatry (in press).
Edmondson, D, Richardson, S, Falzon, L, Davidson, KW, Mills, MA, Neria, Y (2012). Posttraumatic stress disorder prevalence and risk of recurrence in acute coronary syndrome patients: a meta-analytic review. PLoS ONE 7, e38915.
Heppner, PS, Crawford, EF, Haji, UA, Afari, N, Hauger, RL, Dashevsky, BA, Horn, PS, Nunnink, SE, Baker, DG (2009). The association of posttraumatic stress disorder and metabolic syndrome: a study of increased health risk in veterans. BMC Medicine 7, 1.
Koenen, KC, Sumner, JA, Gilsanz, P, Glymour, MM, Ratanatharathorn, A, Rimm, EB, Roberts, AL, Winning, A, Kubzansky, LD (2017). Post-traumatic stress disorder and cardiometabolic disease: improving causal inference to inform practice. Psychological Medicine 47, 209225.
Kubzansky, LD, Bordelois, P, Jun, HJ, Roberts, AL, Cerda, M, Bluestone, N, Koenen, KC (2014). The weight of traumatic stress: a prospective study of posttraumatic stress disorder symptoms and weight status in women. JAMA Psychiatry 71, 4451.
Li, J, Ji, L (2005). Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity 95, 221227.
Logue, MW, Amstadter, AB, Baker, DG, Duncan, L, Koenen, KC, Liberzon, I, Miller, MW, Morey, RA, Nievergelt, CM, Ressler, KJ, Smith, AK, Smoller, JW, Stein, MB, Sumner, JA, Uddin, M (2015). The Psychiatric Genomics Consortium Posttraumatic Stress Disorder Workgroup: posttraumatic stress disorder enters the age of large-scale genomic collaboration. Neuropsychopharmacology 40, 22872297.
Pollard, HB, Shivakumar, C, Starr, J, Eidelman, O, Jacobowitz, DM, Dalgard, CL, Srivastava, M, Wilkerson, MD, Stein, MB, Ursano, RJ (2016). ‘Soldier's heart’: a genetic basis for elevated cardiovascular disease risk associated with post-traumatic stress disorder. Frontiers in Molecular Neuroscience 9, 87.
Roberts, AL, Agnew-Blais, JC, Spiegelman, D, Kubzansky, LD, Mason, SM, Galea, S, Hu, FB, Rich-Edwards, JW, Koenen, KC (2015). Posttraumatic stress disorder and incidence of type 2 diabetes mellitus in a sample of women: a 22-year longitudinal study. JAMA Psychiatry 72, 203210.
Sumner, JA, Kubzansky, LD, Elkind, MS, Roberts, AL, Agnew-Blais, J, Chen, Q, Cerdá, M, Rexrode, KM, Rich-Edwards, JW, Spiegelman, D, Suglia, SF, Rimm, EB, Koenen, KC (2015). Trauma exposure and posttraumatic stress disorder symptoms predict onset of cardiovascular events in women. Circulation 132, 251259.
Vaccarino, V, Goldberg, J, Magruder, KM, Forsberg, CW, Friedman, MJ, Litz, BT, Heagerty, PJ, Huang, GD, Gleason, TC, Smith, NL (2014). Posttraumatic stress disorder and incidence of type-2 diabetes: a prospective twin study. Journal of Psychiatric Research 56, 158164.
Vaccarino, V, Goldberg, J, Rooks, C, Shah, AJ, Veledar, E, Faber, TL, Votaw, JR, Forsberg, CW, Bremner, JD (2013). Post-traumatic stress disorder and incidence of coronary heart disease: a twin study. Journal of the American College of Cardiology 62, 970978.
van Liempt, S, Arends, J, Cluitmans, PJ, Westenberg, HG, Kahn, RS, Vermetten, E (2013). Sympathetic activity and hypothalamo-pituitary-adrenal axis activity during sleep in post-traumatic stress disorder: a study assessing polysomnography with simultaneous blood sampling. Psychoneuroendocrinology 38, 155165.
Wentworth, BA, Stein, MB, Redwine, LS, Xue, Y, Taub, PR, Clopton, P, Nayak, KR, Maisel, AS (2013). Post-traumatic stress disorder: a fast track to premature cardiovascular disease? Cardiology in Review 21, 1622.
Wolf, EJ, Bovin, MJ, Green, JD, Mitchell, KS, Stoop, TB, Barretto, KM, Jackson, CE, Lee, LO, Fang, SC, Trachtenberg, F, Rosen, RC, Keane, TM, Marx, BP (2016). Longitudinal associations between post-traumatic stress disorder and metabolic syndrome severity. Psychological Medicine 46, 22152226.
Zheng, J, Erzurumluoglu, M, Elsworth, B, Howe, L, Haycock, P, Hemani, G, Tansey, K, Laurin, C, Early Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium, Pourcain, BS, Warrington, N, Finucane, HK, Price, AL, Bulik-Sullivan, BK, Anttila, V, Paternoster, L, Gaunt, TR, Evans, DM, Neale, BM (2016). LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis. Bioinformatics 33, 272279.
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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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