Skip to main content Accessibility help
×
×
Home

Positive relationship between the catecholaminergic turnover and the DST results in depression

  • M. Maes (a1), M. Vandewoude (a1), C. Schotte (a1), M. Martin (a1) and P. Blockx (a1)...

Synopsis

In the past some workers have reported positive relationships between indices of noradrenaline activity and measures of hypothalamic–pituitary–adrenal (HPA)-axis function. In order to investigate these relations, the authors measured noradrenaline, adrenaline and vanillylmandelic acid (VMA) in 24 h urine samples of 72 depressed females. Serum adrenocorticotrophic hormone (ACTH) and cortisol concentrations were determined before and after administration of 1 mg of dexamethasone. Cortisol non-suppressors exhibited a significantly higher noradrenaline, adrenaline and VMA excretion as compared to cortisol suppressors. We determined significantly positive correlations between the postdexamethasone cortisol values and the excretion rates of noradrenaline and VMA. These indices of noradrenaline activity correlated neither with the baseline cortisol and ACTH nor with the postdexamethasone ACTH values.

Copyright

Corresponding author

1Address for correspondence: Dr M. Maes, Department of Psychiatry, University Hospital of Antwerp, Wilrijkstraat, 10, 2520 Edegem, Belgium.

References

Hide All
Al-Damluji, S. (1988). Adrenergic mechanisms in the control of corticotropin secretion. Journal of Endocrinology 119, 514.
American Psychiatric Association (1980). Diagnostic and Statistical Manual of Mental Disorders, 3rd edn.American Psychiatric Association: Washington DC.
Bakke, H. K., Murison, R. & Walthers, B. (1986). Effect of central noradrenaline depletion on corticosterone levels and gastric ulceration in rats. Brain Research 368, 256258.
Blombery, P. A., Kopin, I. J., Gordon, E. K.Markey, S. P. & Ebert, M. H. (1980). Conversion of MHPG to vanillylmandelic acid. Archives of General Psychiatry 37, 10951098.
Carroll, B. J. (1980). Clinical application of neuroendocrine research in depression. In Handbook of Biological Psychiatry, Part III, Brain Mechanisms and Abnormal Behaviour–Genetics and Neuroendocrinology (ed. van Praag, H. M., Lader, M. H., Rafaelsen, O. J. and Sachar, E. J.), pp. 179193. Marcel Dekker: New York.
Carroll, B. J. (1982). The dexamethasone suppression test for melancholia. British Journal of Psychiatry 140, 292304.
Davis, K. L., Hollister, L. E., Mathé, A. A., Davis, B. M., Rothpearl, A. B., Faull, K. F., Hsich, J. Y. K., Barchas, J. D. & Berger, P. A. (1981). Neuroendocrine and neurochemical measurements in depression. American Journal of Psychiatry 138, 15551562.
de Villiers, A., Russell, V., Carsters, M., Aalbers, C., Gagiano, C., Charlton, D. & Taljaard, J. (1987). Noradrenergic function and hypothalamic–pituitary–adrenal axis activity in unipolar major depressive disorder. Psychiatry Research 22, 127140.
Feinberg, M. & Carroll, B. J. (1984). Biological ‘markers’ for endogenous depression. Archives of General Psychiatry 41, 10801085.
Filser, J. G., Muller, W. E. & Beckmann, H. (1986). Should plasma or urinary MHPG be measured in psychiatric research? A critical comment. British Journal of Psychiatry 148, 9597.
Garvey, M. J., Hollon, S., Evans, M., DeRubeis, R. J. & Tuason, V. B. (1988). The association of MHPG to dexamethasone suppression test status. Psychiatry Research 24, 223230.
Gibson, A., Hart, S. L. & Patel, S. (1986). Effects of 6-hydroxydopamine-induced lesions of the paraventricular nucleus and of prarosin, on the corticosteron response to restraint in rats. Neuropharmacology 25, 257262.
Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry 23, 5661.
Jimerson, D. C., Insel, T. R., Reus, V. I. & Kopin, I. J. (1983). Increased plasma MHPG in dexamethasone-resistant depressed patients. Archives of General Psychiatry 40, 173176.
Koslow, S. H., Maas, J. W., Bowden, C. L., Davis, J. M., Hanin, I. & Javaid, J. (1983). CSF and urinary biogenic amines and metabolites in depression and mania: a controlled, univariate analysis. Archives of General Psychiatry 40, 9991010.
Linnoila, M., Karoum, F. & Potter, W. Z. (1982). High correlation of norepinephrine and its major metabolite excretion ranges. Archives of General Psychiatry 39, 521523.
Linnoila, M., Guthrie, S., Lane, E., Karoum, F., Rudorfer, M. & Potter, W. (1986). Clinical studies on norepinephrine metabolism: how to interpret the numbers. Psychiatry Research 17, 229239.
Loo, H., Poirier, M.-F., Dennis, T., Benkelfat, C., Vannelle, J. M., Gay, C., Galinowski, A., Askienazy, S. & Scatton, B. (1988). Lack of correlation between DST results and urinary MHPG in depressed patients. Journal of Neural Transmission 72, 121130.
Maas, J. W. & Leckmann, J. F. (1983). Relationships between central nervous system noradrenergic function and plasma and urinary MHPG and other norepinephrine metabolites, in MHPG: Basic Mechanisms and Psychopathology (ed. Maas, J.), pp. 3334. Academic Press: New York.
Maes, M., De Ruyter, M., Hobin, P. & Suy, E. (1986). The dexamethasone suppression test, the Hamilton depression rating scale and the DSM-III depression categories. Journal of Affective Disorders 10, 207214.
Maes, M., De Ruyter, M. & Suy, E. (1987 a). Cortisol response to dexamethasone and noradrenergic function in depression. Acta Psychiatrica Scandinavica 75, 171175.
Maes, M., De Ruyter, M. & Suy, E. (1987 b). Prediction of subtype and severity of depression by means of dexamethasone suppression test, L-tryptophan/competing amino acid ratio and MHPG excretion. Biological Psychiatry 22, 177186.
Maas, J. W., Koslow, S. H., Davis, J., Katz, M., Frazer, A., Bowden, C. L., Berman, N., Gibbons, R., Stokes, P. & Landis, H. (1987 c). Catecholamine metabolism and disposition in healthy and depressed subjects. Archives of General Psychiatry 44, 337344.
Maes, M., Jacobs, M.-P., Suy, E., Leclercq, C., Christiaens, F. & Raus, J. (1989 a). An augmented escape of β-endorphins to suppression by dexamethasone in severely depressed patients. Journal of Affective Disorders (in the press).
Maes, M., Vandevelde, R. & Suy, E. (1989 b). Influences on cortisol and noradrenergic turnover of healthy controls and depressed patients during L-tryptophan loading. Journal of Affective Disorders 17, 173182.
Maes, M., Vandewoude, M., Maes, L., Schotte, C. & Cosyns, P. (1989 c). A revised interpretation of the TRH test results in female depressed patients. Part I. TSH responses. Effects of severity of illness, thyroid hormones, monoamines, age, sex hormonal, corticosteroid and nutritional state. Journal of Affective Disorders 16, 203213.
Maes, M., Schotte, C., Martin, M., Vandewoude, M. & Blockx, P. (1990). A revised interpretation of the postdexamethasone ACTH and cortisol data in unipolar depressed females. Psychiatry Research (in the press).
Martin, J. B. & Reichlin, S. (1987). Regulation of ACTH secretion and its disorders. In Clinical Neuroendocrinology, 2nd edn. (ed. Martin, J. B. & Reichlin, S.), pp. 159200. F. A. Davis: Philadelphia.
Massart, D. L., Vandeginste, B. G. M., Deming, S. N., Michotte, Y. & Kaufman, L. (1988). Data Handling in Science and Technology, Chemometrics: a Textbook. Elsevier: Amsterdam.
Post, R., Jimerson, D., Ballenger, J., Lake, R., Uhde, T. & Goodwin, F. (1984). Cerebrospinal fluid norepinephrine and its metabolites in manic-depressive illness. In Neurobiology of Mood Disorders(ed. Post, R. and Ballenger, J.), pp. 539553. Williams & Wilkins: Baltimore.
Rivier, C. & Vale, W. (1985). Effects of corticotropin-releasing factor, neurohypophyseal peptides, and catecholamines on pituitary function. Federation Proceedings 44, 189196.
Rosenbaum, A. H., Maruta, T., Schatzberg, A. F., Orsulak, P. J., Jiang, N.-S., Cole, J. O. & Schildkraut, J. J. (1983). Toward a biochemical classification of depressive disorders. VII. Urinary free cortisol and urinary MHPG in depression. American Journal of Psychiatry 140, 314318.
Roy, A., Pickar, D., Linnoila, M. & Potter, W. (1985). Plasma norepinephrine in affective disorders: relationship to melancholia. Archives of General Psychiatry 42, 11811185.
Roy, A., Jimerson, D. & Pickar, D. (1986). Plasma 3-methoxy-4-hydroxyphenylethyleneglycol in depressive disorders. American Journal of Psychiatry 143, 846851.
Roy, A., Pickar, D., De Jong, J., Karoum, F. & Linnoila, M. (1988). Norepinephrine and its metabolites in cerebrospinal fluid, plasma and urine. Archives of General Psychiatry 45, 849857.
Rubin, A. L., Price, L. H., Charney, D. S. & Henninger, G. R. (1985). Noradrenergic function and the cortisol response to dexamethasone in depression. Psychiatry Research 15, 515.
Siever, L. & Davis, K. (1985). Overview: toward a dysregulation hypothesis of depression. American Journal of Psychiatry 142, 10171031.
Spitzer, R. L., Williams, J. B. W. & Gibbon, M. (1985). Structured Clinical Interview for DSM-III Patient Version. Biometrics Research Department, New York State Psychiatric Institute, 722 West 168th Street, New York, NY 10032.
Stene, M., Panagiotis, N., Tuck, M. L., Sowers, J. R., Mayes, D. & Berg, G. (1980). Plasma norepinephrine levels are influenced by sodium intake, glucocorticoid administration and circadian changes in normal man. Journal of Clinical Endocrinology and Metabolism 51, 13401345.
Sternbach, H. A., Extein, I., Sweeney, D. R., Gold, M. S. & Pottash, A. L. C. (1983). Cortisol secretion and urinary MHPG in unipolar depression. International Journal of Psychiatry in Medicine 13, 261266.
Stokes, P. E., Frazer, A. & Casper, R. (1981). Unexpected neuroendocrine transmitter relationships. Psychopharmacological Bulletin 17, 7275.
Tilders, F. J. H., Berkenbosch, F., Vernes, I., Linton, E. A. & Smelik, P. G. (1985). Role of epinephrine and vasopressin in the control of the pituitary adrenal response to stress. Federation Proceedings 44, 155160.
Valentino, R., Foote, S. & Aston-Jones, G. (1983). Corticotropin-releasing factor activates noradrenergic neurons of the locus coeruleus. Brain Research 270, 363367.
Warsh, J. J., Hasey, G., Cooke, R., Stancer, H. C., Persad, E, Jorna, T. & Godse, D. D. (1985). Elevated 3, 4-dihydroxyphenyl ethyleneglycol (DHPG) excretion in dexamethasone-resistant depressed patients. Progress in Neuropsychopharmacology and Biological Psychiatry 9, 661664.
Wolkowitz, O. M., Doran, A. R., Breier, A., Roy, A. & Jimerson, D. C. (1987). The effects of dexamethasone on plasma homo-vanillic acid and 3-methoxy-4-hydroxyphenylglycol; evidence for abnormal corticosteroid–catecholamine interactions in major depression. Archives of General Psychiatry 44, 782789.
Zhou, D., Shen, Y., Shu, L. & Lo, H., (1987). Dexamethasone suppression test and urinary MHPG-SO4 determination in depressive disorder. Biological Psychiatry 22, 883891.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed