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Reversibility of brain tissue loss in anorexia nervosa assessed with a computerized Talairach 3-D proportional grid

  • V. W. Swayze (a1), A. Andersen (a1), S. Arndt (a1), R. Rajarethinam (a1), F. Fleming (a1), Y. Sato (a1) and N. C. Andreasen (a1)...
Synopsis
Synopsis

We describe the results of our follow-up magnetic resonance imaging (MRI) study of underweight patients with anorexia nervosa, using rigorous methodology to control for head position across time. All subjects first underwent an initial scan and rescan to verify that our computerized three-dimensional co-planar grid method for volume measurement was reliable and accurate, regardless of head positioning. After a period of several months, subjects had a follow-up scan to assess for changes that may have occurred following significant weight gain.

Ventricular and total brain volume measurements from the initial scans were compared with the scans from an age- and sex-matched normal control group to determine whether we could replicate previous findings of ventricular enlargement compared with controls and whether brain volume is reduced compared with controls. Anorexic subjects had significantly larger ventricles when compared with normal controls but did not differ significantly in total brain volume. Using a repeated measures analysis of variance, a priori contrasts compared the initial/rescan pair volumes with each other and the initial/rescan pair volumes with the follow-up volume. These analyses showed that ventricular and total brain volumes derived from the initial/rescan pair were nearly identical, but that at follow-up ventricular volume decreased significantly and total brain volume increased significantly after weight gain.

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1Address for correspondence: Dr Victor W. Swayze II, VA Medical Center, Iowa city, IA 52246–2208. USA.
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H. Artmann , H. Grau , M. Adelmann & R. Schleiffer (1985). Reversible and non-reversible enlargement of cerebrospinal fluid spaces in anorexia nervosa. Neuroradiology 27, 304312.

J. Bentson , M. Reza , J. Winter & G. Wilson (1978). Steroids and apparent cerebral atrophy on computed tomography scans. Journal of Computer Assisted Tomography 2, 1623.

J. B. Bodensteiner & G. B. Schaefer (1990). Wide cavum septum pellucidum: a marker of disturbed brain development. Pediatric Neurology 6, 391394.

L. M. Breeding , J. B. Bodensteiner , L. Cowan & W. L. Higgins (1992). The cavum septi pellucidi: a magnetic resonance imaging study of prevalence and clinical associations in a pediatric population. Journal of Neuroimaging 1, 115118.

G. Cohen , N. C. Andreasen , R. Alliger , S. Arndt , J. Kuan , W. T. C. Yuh & J. Ehrhardt (1992). Segmentation techniques for the classification of brain tissue using magnetic resonance imaging. Psychiatry Research: Neuroimaging 45, 3351.

H. F. Cserr , M. DePasquale , C. Nicholson , C. S. Patlak , K. D. Pettigrew & M. E. Rice (1991). Extracellular volume decreases while cell volume is maintained by ion uptake in rat brain during acute hypernatremia. Journal of Physiology 442, 277295.

L. E. DeLisi , A. L. Hoff , M. Kushner & G. Degreef (1993). Increased prevalence of cavum septum pellucidum in schizophrenia. Psychiatry Resarch: Neuroimaging 50, 193199.

D. R. Enzmann & B. Lane (1977). Cranial computed tomography findings in anorexia nervosa. Journal of Computer Assisted Tomography 1, 410414.

R. Heidrich & H. Schmidt-Matthias (1961). Encephalographische Befunde bei Anorexia nervosa. Archiv für Psychiatrie und Zeitschrift Neurologie 202, 183201.

E. R. Heinz , J. Martinez & A. Haenggeli (1977). Reversibility of cerebral atrophy in anorexia nervosa and Cushing's syndrome. Journal of Computer Assisted Tomography 1, 415418.

G. W. Hoffman Jr., E. H. Ellinwood Jr., W. J. K. Rockwell , R. J. Herfkens , J. K. Nishita & L. F. Guthrie (1989). Cerebral atrophy in anorexia nervosa: a pilot study. Biological Psychiatry 26, 321324.

J.-C. Krieg , H. Backmund & K.-M. Pirke (1986). Endocrine, metabolic, and brain morphological abnormalities in patients with eating disorders. International Journal of Eating Disorders 5, 9991005.

J.-C. Krieg , K.-M. Pirke , C. Lauer & H. Backmund (1988). Endocrine, metabolic, and cranial computed tomographic findings in anorexia nervosa. Biological Psychiatry 23, 377387.

J.-C. Krieg , C. Lauer , G. Leinsinger , J. Pahl , W. Schreiber , K.-M. Pirke & E. A. Moser (1989). Brain morphology and regional cerebral blood flow in anorexia nervosa. Biological Psychiatry 25, 10411048.

C. L. Kroft , B. Gescuk , B. T. Woods , N. K. Mello , R. D. Weiss & J. H. Mendelson (1991). Brain ventricular size in female alcoholics: an MRI study. Alcohol 8, 3134.

I. Lagenstein , R. P. Willig & D. Kühne (1979). Cranial computed tomography (CCT) findings in children treated with ACTH and dexamethasone: first results. Neuropädiatrie 10, 370384.

H. Lankenau , M. E. Swigar , S. Bhimani , D. Luchins & D. M. Quinlan (1985). Cranial CT scans in eating disorder patients and controls. Comprehensive Psychiatry 26, 136147.

M. E. Miller , D. Kido & F. Horner (1986). Cavum vergae: association with neurologic abnormality and diagnosis by magnetic resonance imaging. Archives of Neurology 43, 821823.

K. J. Momose , R. N. Kjellberg & B. Kliman (1971). High incidence of cortical atrophy of the cerebral and cerebellar hemispheres in Cushing's disease. Radiology 99, 341348.

M. Nussbaum , I. R. Shenker , J. Marc & M. Klein (1980). Cerebral atrophy in anorexia nervosa. Journal of Pediatrics 96, 867869.

T. Okuno , M. Ito , Y. Konishi , M. Yoshioka & Y. Nakano (1980). Cerebral atrophy following ACTH therapy. Journal of Computer Assisted Tomography 4, 2023.

S. R. Sponheim , W. G. Iacono & M. Beiser (1991). Stability of ventricular size after the onset of psychosis in schizophrenia. Psychiatry Research: Neuroimaging 40, 2129.

M. Takase , A. Tokunaga , K. Otani & T. Horie (1977). Atlas of the human brain for computed tomography based on the glabellainion line. Neuroradiology 14, 7379.

A. Tokunaga , M. Takase & K. Otani (1977). The glabella-inion line as a baseline for CT scanning of the brain. Neuroradiology 14, 6771.

B. T. Woods , A. Douglass & B. Gescuk (1991). Is the VBR still a useful measure of changes in the cerebral ventricles? Psychiatry Research: Neuroimaging 40, 110.

H. Zeumer , W. Hacke & P. Hartwich (1982). A quantitative approach to measuring the cerebrospinal fluid space with CT. Neuroradiology 22, 193197.

R. B. Zipursky , K. O. Lim & A. Pfefferbaum (1989). MRI study of brain changes with short-term abstinence from alcohol. Alcoholism 13, 664666.

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Psychological Medicine
  • ISSN: 0033-2917
  • EISSN: 1469-8978
  • URL: /core/journals/psychological-medicine
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