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Salience of working-memory maintenance and manipulation deficits in schizophrenia

  • S. K. Hill (a1), G. B. Griffin (a1), T. Kazuto Miura (a2), E. S. Herbener (a1) and J. A. Sweeney (a1)
  • DOI:
  • Published online: 10 March 2010

Encoding and maintenance of information in working memory, followed by internal manipulation of that information for planning adaptive behavior, are two key components of working-memory systems. Both processes have been reported to be impaired in schizophrenia, but few studies have directly compared the relative severity of these abnormalities, or the degree to which manipulation deficits might be secondary to alterations in maintenance processes.


Clinically stable schizophrenia patients (n=25) and a demographically similar healthy comparison group (n=24) were administered a verbal span task with three levels of working-memory load. Maintenance was assessed using sequential position questions. Manipulation processes were assessed by requiring comparison of the relative sequential position of test items, which entailed simultaneous serial search strategies regarding item order.


Both groups showed reduced accuracy and increased reaction time for manipulation compared with maintenance processing. There were significant patient impairments across working-memory loads. There was no differential deficit in manipulation processing, and effect sizes of relative deficit in the patient group were higher for maintenance than manipulation processing.


The strong correlation for maintenance and manipulation deficits suggest that impairments in the ability to internally manipulate information stored in working-memory systems are not greater than alterations in the encoding and maintaining of information in working memory and that disturbances in maintenance processing may contribute to deficits in higher-order working-memory operations.

Corresponding author
*Address for correspondence: Dr S. Kristian Hill, Center for Cognitive Medicine, Department of Psychiatry (M/C 913), University of Illinois at Chicago, 912 South Wood Street, Suite 235, Chicago, IL60612, USA. (Email:
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A Baddeley (2000). The episodic buffer: a new component of working memory? Trends in Cognitive Sciences 4, 417423.

A Baddeley (2003). Working memory: looking back and looking forward. Nature Reviews Neuroscience 4, 829839.

DM Barch , CS Carter , TS Braver , FW Sabb , A MacDonald III, DC Noll , JD Cohen (2001). Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia. Archives of General Psychiatry 58, 280288.

TA Cairo , TS Woodward , ET Ngan (2006). Decreased encoding efficiency in schizophrenia. Biological Psychiatry 59, 740746.

TD Cannon , DC Glahn , J Kim , TG van Erp , K Karlsgodt , MS Cohen , KH Nuechterlein , S Bava , D Shirinyan (2005). Dorsolateral prefrontal cortex activity during maintenance and manipulation of information in working memory in patients with schizophrenia. Archives of General Psychiatry 62, 10711080.

M D'Esposito , GK Aguirre , E Zarahn , D Ballard , RK Shin , J Lease (1998). Functional MRI studies of spatial and nonspatial working memory. Cognitive Brain Research 7, 113.

M D'Esposito , BR Postle , D Ballard , J Lease (1999). Maintenance versus manipulation of information held in working memory: an event-related fMRI study. Brain and Cognition 41, 6686.

NR Driesen , HC Leung , VD Calhoun , RT Constable , R Gueorguieva , R Hoffman , P Skudlarski , PS Goldman-Rakic , JH Krystal (2008). Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence. Biol Psychiatry 64, 10261034.

D Fraser , S Park , G Clark , D Yohanna , JC Houk (2004). Spatial serial order processing in schizophrenia. Schizophrenia Research 70, 203213.

DC Glahn , J Kim , MS Cohen , VP Poutanen , S Therman , S Bava , TG van Erp , M Manninen , M Huttunen , J Lonnqvist , CG Standertskjold-Nordenstam , TD Cannon (2002). Maintenance and manipulation in spatial working memory: dissociations in the prefrontal cortex. Neuroimage 17, 201213.

SB Hutton , V Huddy , TR Barnes , TW Robbins , TJ Crawford , C Kennard , EM Joyce (2004). The relationship between antisaccades, smooth pursuit, and executive dysfunction in first-episode schizophrenia. Biological Psychiatry 56, 553559.

KH Karlsgodt , J Sanz , TG van Erp , CE Bearden , KH Nuechterlein , TD Cannon (2009). Re-evaluating dorsolateral prefrontal cortex activation during working memory in schizophrenia. Schizophrenia Research 108, 143150.

SK Keedy , CL Ebens , MS Keshavan , JA Sweeney (2006). Functional magnetic resonance imaging studies of eye movements in first episode schizophrenia: smooth pursuit, visually guided saccades and the oculomotor delayed response task. Psychiatry Research 146, 199211.

J Kim , DC Glahn , KH Nuechterlein , TD Cannon (2004). Maintenance and manipulation of information in schizophrenia: further evidence for impairment in the central executive component of working memory. Schizophrenia Research 68, 173187.

J Lee , S Park (2005). Working memory impairments in schizophrenia: a meta-analysis. Journal of Abnormal Psycholology 114, 599611.

T Lencz , RM Bilder , E Turkel , RS Goldman , D Robinson , JM Kane , JA Lieberman (2003). Impairments in perceptual competency and maintenance on a visual delayed match-to-sample test in first-episode schizophrenia. Archives of General Psychiatry 60, 238243.

A Low , B Rockstroh , S Harsch , P Berg , R Cohen (2000). Event-related potentials in a working-memory task in schizophrenics and controls. Schizophrenia Research 46, 175186.

AW MacDonald III, CS Carter , JG Kerns , S Ursu , DM Barch , AJ Holmes , VA Stenger , JD Cohen (2005). Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis. American Journal of Psychiatry 162, 475484.

DS Manoach (2003). Prefrontal cortex dysfunction during working memory performance in schizophrenia: reconciling discrepant findings. Schizophrenia Research 60, 285298.

VS Mattay , TE Goldberg , F Fera , AR Hariri , A Tessitore , MF Egan , B Kolachana , JH Callicott , DR Weinberger (2003). Catechol O-methyltransferase val158-met genotype and individual variation in the brain response to amphetamine. Proceedings of the National Academy of Sciences in the U.S.A 100, 61866191.

A Miyake , P Shah (1999). Toward unified theories of working memory: Emerging general consensus, unresolved theoretical issues, and future research directions. In Models of Working Memory: Mechanisms of Maintenance and Executive Control (ed. A. Miyake and P. Shah ), pp. 442481. Cambridge University Press: New York.

M Myles-Worsley , S Park (2002). Spatial working memory deficits in schizophrenia patients and their first degree relatives from Palau, Micronesia. American Journal of Medical Genetics 114, 609615.

AM Owen , AC Evans , M Petrides (1996). Evidence for a two-stage model of spatial working memory processing within the lateral frontal cortex: a positron emission tomography study. Cerebral Cortex 6, 3138.

C Pantelis , TR Barnes , HE Nelson , S Tanner , L Weatherley , AM Owen , TW Robbins (1997). Frontal-striatal cognitive deficits in patients with chronic schizophrenia. Brain 120, 18231843.

S Park (1999). Hemispheric asymmetry of spatial working memory deficit in schizophrenia. International Journal of Psychophysiology 34, 313322.

S Park , PS Holzman (1992). Schizophrenics show spatial working memory deficits. Archives of General Psychiatry 49, 975982.

S Park , PS Holzman (1993). Association of working memory deficit and eye tracking dysfunction in schizophrenia. Schizophrenia Research 11, 5561.

S Park , PS Holzman , PS Goldman-Rakic (1995). Spatial working memory deficits in the relatives of schizophrenic patients. Archives of General Psychiatry 52, 821828.

S Park , J Puschel , BH Sauter , M Rentsch , D Hell (1999). Spatial working memory deficits and clinical symptoms in schizophrenia: a 4-month follow-up study. Biological Psychiatry 46, 392400.

S Park , J Puschel , BH Sauter , M Rentsch , D Hell (2003). Visual object working memory function and clinical symptoms in schizophrenia. Schizophrenia Research 59, 261268.

JL Reilly , MS Harris , MS Keshavan , JA Sweeney (2006). Adverse effects of risperidone on spatial working memory in first-episode schizophrenia. Archives of General Psychiatry 63, 11891197.

JL Reilly , MS Harris , TT Khine , MS Keshavan , JA Sweeney (2008). Reduced attentional engagement contributes to deficits in prefrontal inhibitory control in schizophrenia. Biological Psychiatry 63, 776783.

JL Reilly , MSH Harris , TT Khine , MS Keshavan , JA Sweeney (2007). Antipsychotic drugs exacerbate impairment on a working memory task in first-episode schizophrenia. Biological Psychiatry 62, 818821.

B Rypma , JS Berger , M D'Esposito (2002). The influence of working-memory demand and subject performance on prefrontal cortical activity. Journal of Cognitive Neuroscience 14, 721731.

HY Tan , JH Callicott , DR Weinberger (2007). Dysfunctional and compensatory prefrontal cortical systems, genes and the pathogenesis of schizophrenia. Cerebral Cortex 17, 171181.

HY Tan , WC Choo , CS Fones , MW Chee (2005). fMRI study of maintenance and manipulation processes within working memory in first-episode schizophrenia. American Journal of Psychiatry 162, 18491858.

HY Tan , S Sust , JW Buckholtz , VS Mattay , A Meyer-Lindenberg , MF Egan , DR Weinberger , JH Callicott (2006). Dysfunctional prefrontal regional specialization and compensation in schizophrenia. American Journal of Psychiatry 163, 19691977.

DJ Veltman , SA Rombouts , RJ Dolan (2003). Maintenance versus manipulation in verbal working memory revisited: an fMRI study. Neuroimage 18, 247256.

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Psychological Medicine
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