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The heritability of hedonic capacity and perceived stress: a twin study evaluation of candidate depressive phenotypes

  • R. Bogdan (a1) and D. A. Pizzagalli (a1)
  • DOI: http://dx.doi.org/10.1017/S0033291708003619
  • Published online: 28 May 2008
Abstract
Background

Anhedonia and stress sensitivity have been identified as promising depressive phenotypes. Research suggests that stress-induced anhedonia is a possible mechanism underlying the association between stress and depression. The present proof-of-concept study assessed whether hedonic capacity and stress perception are heritable and whether their genetic and environmental contributions are shared.

Method

Twenty monozygotic (MZ) and 15 dizygotic (DZ) twin pairs completed a probabilistic reward task that provides an objective behavioral measure of hedonic capacity (reward responsiveness) and completed several questionnaires including the Perceived Stress Scale (PSS). Bivariate Cholesky models were used to investigate whether covariation between (1) depressive symptoms and hedonic capacity, (2) depressive symptoms and perceived stress, and (3) perceived stress and hedonic capacity resulted from shared or residual genetic and environmental factors.

Results

Additive genetic (A) and individual-specific environment (E) factors contributed to 46% and 54% of the variance in hedonic capacity, respectively. For perceived stress, 44% and 56% of the variance was accounted for by A and E factors, respectively. The genetic correlation between depression and hedonic capacity was moderate (ra=0.29), whereas the correlation between depression and stress perception was large (ra=0.67). Genetic and environmental correlations between hedonic capacity and stress perception were large (ra=0.72 and re=−0.43).

Conclusions

The present study provides initial feasibility for using a twin approach to investigate genetic contributions of a laboratory-based anhedonic phenotype. Although these preliminary findings indicate that hedonic capacity and perceived stress are heritable, with substantial shared additive genetic contributions, replications in larger samples will be needed.

Copyright
Corresponding author
*Address for correspondence: D. A. Pizzagalli, Ph.D., Department of Psychology, Harvard University, 1220 William James Hall, 33 Kirkland Street, Cambridge, MA 02138, USA. (Email: dap@wjh.harvard.edu)
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This list contains references from the content that can be linked to their source. For a full set of references and notes please see the PDF or HTML where available.

H Anisman , K Matheson (2005). Stress, depression, and anhedonia: caveats concerning animal models. Neuroscience and Biobehavioral Reviews 29, 525546.

H Berenbaum , J Connelly (1993). The effect of stress on hedonic capacity. Journal of Abnormal Psychology 102, 474481.


KC Berridge , ML Kringelbach (2008). Affective neuroscience of pleasure: reward in humans and animals. Psychopharmacology. Published online: 3 March 2008. doi:10.1007/s00213-008-1099-6.

R Bogdan , DA Pizzagalli (2006). Acute stress reduces hedonic capacity: implications for depression. Biological Psychiatry 60, 11471154.

M Candrian , A Farabaugh , DA Pizzagalli , L Baer , M Fava (2007). Perceived stress and cognitive vulnerability mediate the effects of personality disorder comorbidity on treatment outcome in major depressive disorder. Journal of Nervous and Mental Disease 195, 729737.

S Cohen , T Kamarck , R Mermelstein (1983). A global measure of perceived stress. Journal of Health and Social Behavior 24, 385–196.

RH Dworkin , K Saczynski (1984). Individual differences in hedonic capacity. Journal of Personality Assessment 48, 620626.


G Hasler , WC Drevets , HK Manji , DS Charney (2004). Discovering endophenotypes for major depression. Neuropsychopharmacology 29, 17651781.

DA Hay , NG Martin , D Foley , SA Treloar , KM Kirk , AC Heath (2001). Phenotypic and genetic analyses of a short measure of psychosis-proneness in a large-scale Australian twin study. Twin Research 4, 3040.

AC Heath , CR Cloninger , NG Martin (1994). Testing a model for the genetic structure of personality: a comparison of the personality systems of Cloninger and Eysenck. Journal of Personality and Social Psychology 66, 762775.

SE Hyman (2007). Can neuroscience be integrated into the DSM-V? Nature Reviews Neuroscience 8, 725732.

SE Hyman , RC Malenka , EJ Nestler (2006). Neural mechanisms of addiction: the role of reward-related learning and memory. Annual Review of Neuroscience 29, 565598.

KL Kasch , J Rottenberg , BA Arnow , IH Gotlib (2002). Behavioral activation and inhibition systems and the severity and course of depression. Journal of Abnormal Psychology 111, 589597.

PA Keedwell , C Andrew , SC Williams , MJ Brammer , ML Phillips (2005). The neural correlates of anhedonia in major depressive disorder. Biological Psychiatry 58, 843853.

MC Keller , WL Coventry , AC Heath , NG Martin (2005). Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design. Behavior Genetics 35, 707721.


KS Kendler , M Gatz , CO Gardner , NL Pedersen (2006). Personality and major depression: a Swedish longitudinal, population-based twin study. Archives of General Psychiatry 63, 11131120.

KS Kendler , AL Ochs , AM Gorman , JK Hewitt , DE Ross , AF Mirsky (1991). The structure of schizotypy: a pilot multitrait twin study. Psychiatry Research 36, 1936.

MJ Kreek , DA Nielsen , ER Butelman , KS LaForge (2005). Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nature Neuroscience 8, 14501457.


G Loas (1996). Vulnerability to depression: a model centered on anhedonia. Journal of Affective Disorders 41, 3953.

AW III MacDonald , MF Pogue-Geile , TT Debski , S Manuck (2001). Genetic and environmental influences on schizotypy: a community-based twin study. Schizophrenia Bulletin 27, 4758.

SC Matthews , AN Simmons , I Strigo , K Jang , MB Stein , MP Paulus (2007). Heritability of anterior cingulate response to conflict: an fMRI study in female twins. NeuroImage 38, 223227.

A Meyer-Lindenberg , DR Weinberger (2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews Neuroscience 7, 818827.

Y Ono , J Ando , N Onoda , K Yoshimura , T Momose , M Hirano , S Kanba (2002). Dimensions of temperament as vulnerability factors in depression. Molecular Psychiatry 7, 948953.

RE Orstavik , KS Kendler , N Czajkowski , K Tambs , T Reichborn-Kjennerud (2007). The relationship between depressive personality disorder and major depressive disorder: a population-based twin study. American Journal of Psychiatry 164, 18661872.

C Otte , J McCaffery , S Ali , MA Whooley (2007). Association of a serotonin transporter polymorphism (5-HTTLPR) with depression, perceived stress, and norepinephrine in patients with coronary disease: the Heart and Soul Study. American Journal of Psychiatry, 164, 13791384.

DA Pizzagalli , R Bogdan , KG Ratner , AL Jahn (2007). Increased perceived stress is associated with blunted hedonic capacity: potential implications for depression research. Behaviour Research and Therapy 45, 27422753.

DA Pizzagalli , AE Evins , E Schetter Cowman , MJ Frank , PE Pajtas , DL Santesso , M Culhane (2008 a). Single dose of a dopamine agonist impairs reinforcement learning in humans: behavioral evidence from a laboratory-based measure of reward responsiveness. Psychopharmacology 196, 221232.

DA Pizzagalli , D Iosifescu , LA Hallett , KG Ratner , M Fava (2008 b). Reduced hedonic capacity in major depressive disorder: evidence from a probabilistic reward task. Journal of Psychiatric Research. Published online: 21 April 2008. doi:10.1016/j.jpsychires.2008.03.001.

DA Pizzagalli , AL Jahn , JP O'Shea (2005). Toward an objective characterization of an anhedonic phenotype: a signal detection approach. Biological Psychiatry 57, 319327.

FV Rijsdijk , PC Sham (2002). Analytic approaches to twin data using structural equation models. Briefings in Bioinformatics 3, 119133.

G Tripp , B Alsop (1999). Sensitivity to reward frequency in boys and with attention deficit hyperactivity disorder. Journal of Clinical Child Psychology 28, 366375.

D Watson , K Weber , JS Assenheimer , LA Clark , ME Strauss , RA McCormick (1995). Testing a tripartite model: I. Evaluating the convergent and discriminant validity of anxiety and depression symptom scales. Journal of Abnormal Psychology 104, 314.

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