Skip to main content
×
×
Home

Effects of a lifestyle modification programme to reduce the number of risk factors for metabolic syndrome: a randomised controlled trial

  • Mariko Watanabe (a1), Masako Yokotsuka (a1), Kazue Yamaoka (a2), Misa Adachi (a3), Asuka Nemoto (a2) and Toshiro Tango (a2) (a4)...
Abstract
Objective

To determine the effectiveness of a personal support lifestyle education programme (PSMetS) for reducing risk factors in individuals with metabolic syndrome (MetS).

Design

A two-arm randomised controlled trial.

Setting

Companies in metropolitan Tokyo, Japan.

Subjects

Male workers with diagnosed MetS or a high risk for MetS according to the Counselling Guidance Program, Japan (n 193).

Results

The reduction in the number of risk factors for MetS (as defined according to the criteria published by the Japanese Ministry of Health, Labor and Welfare in April 2007 (MHLW-MetS)) in the PSMetS group was not significantly different from that in the usual care group by van Elteren’s test (baseline-adjusted P=0·075) for intention-to-treat (ITT), while it was significant (baseline-adjusted P=0·038) for per-protocol set (PPS). The proportion of MHLW-MetS was significantly different between groups by van Elteren’s test (baseline-adjusted P=0·031). Two components of MHLW-MetS showed significant reductions in the PSMetS group: waist circumference (baseline-adjusted P=0·001) and BMI (baseline-adjusted P=0·002). PPS and ITT analyses showed similar results.

Conclusions

For male workers with MHLW-MetS or a high risk of MHLW-MetS, PSMetS reduced the number of risk factors for MHLW-MetS.

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Effects of a lifestyle modification programme to reduce the number of risk factors for metabolic syndrome: a randomised controlled trial
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Effects of a lifestyle modification programme to reduce the number of risk factors for metabolic syndrome: a randomised controlled trial
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Effects of a lifestyle modification programme to reduce the number of risk factors for metabolic syndrome: a randomised controlled trial
      Available formats
      ×
Copyright
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Corresponding author
* Corresponding author: Email kazue@med.teikyo-u.ac.jp
References
Hide All
1. Eckel, RH, Grundy, SM & Zimmet, PZ (2005) The metabolic syndrome. Lancet 365, 14151428.
2. Kenko, E & Joho, K (2013) The National Health and Nutrition Survey in Japan 2011. Tokyo: Daiichi-shuppan.
3. Lorenzo, C, Okoloise, M, Williams, K et al. (2003) The metabolic syndrome as predictor of type 2 diabetes. Diabetes Care 26, 31533159.
4. Isooma, B, Almgren, P, Tuomi, T et al. (2001) Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 24, 683689.
5. Gallagher, EJ & LeRoith, D (2013) Epidemiology and molecular mechanisms tying obesity, diabetes, and the metabolic syndrome with cancer. Diabetes Care 36, Suppl. 2, S233S239.
6. Alberti, KG, Zimmet, P & Shaw, J (2006) Metabolic syndrome – a new world-wide definition. A consensus statement from the International Diabetes Federation. Diabetes Med 23, 469480.
7. World Health Organization (1999) Definition, Diagnosis, and Classification of Diabetes Mellitus and Its Complications: Report of a WHO Consultation. Geneva: WHO.
8. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285, 24862497.
9. The Examination Committee of Criteria for ‘Metabolic Syndrome’ in Japan (2005) Criteria for ‘metabolic syndrome’ in Japan. J Jpn Soc Intern Med 94, 188203 (in Japanese).
10. Ministry of Health, Welfare, and Labor (2007) A Standard Health Checkup and Counseling Guidance Program, Guideline for the Treatment of Diabetes, Arteriosclerosis, Hypertension, Obesity Related on Each Medical Congress in Japan (Determination Edition). Tokyo: Ministry of Health, Welfare, and Labor (in Japanese).
11. Yamaoka, K & Tango, T (2012) Effects of lifestyle modification on metabolic syndrome: a systematic review and meta-analysis. BMC Med 10, 138.
12. Poppitt, SD, Keogh, GF, Prentice, AM et al. (2002) Long-term effects of ad libitum low-fat, high-carbohydrate diets on body weight and serum lipids in overweight subjects with metabolic syndrome. Am J Clin Nutr 75, 1120.
13. Esposito, K, Marfella, R, Ciotola, M et al. (2004) Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 292, 14401446.
14. Azadbakht, L, Mirmiran, P, Esmaillzadeh, A et al. (2005) Beneficial effects of a dietary approach to stop hypertension eating plan on features of the metabolic syndrome. Diabetes Care 28, 28232831.
15. Bo, S, Ciccone, G, Baldi, C et al. (2007) Effectiveness of a lifestyle intervention on metabolic syndrome. A randomized controlled trial. J Gen Intern Med 22, 16951703.
16. Maruyama, C, Kimura, M, Okumura, H et al. (2010) Effect of a worksite-based intervention program on metabolic parameters in middle-aged male white-collar workers: a randomized controlled trial. Prev Med 51, 1117.
17. Yamashiro, T, Nishikawa, T, Isami, S et al. (2010) The effect of group-based lifestyle interventions on risk factors and insulin resistance in subjects at risk for metabolic syndrome: the Tabaruzaka Study 1. Diabetes Obes Metab 12, 790797.
18. Nanri, A, Tomita, K, Matsushita, Y et al. (2012) Effect of six months lifestyle intervention in Japanese men with metabolic syndrome: randomized controlled trial. J Occup Health 54, 215222.
19. Okauchi, Y, Nishizawa, H, Funahashi, T et al. (2007) Reduction of visceral fat is associated with reduction in the number of metabolic risk factors in Japanese men. Diabetes Care 30, 23922394.
20. Yamaoka, K, Tango, T, Watanabe, M et al. (2000) Validity and reproducibility of a semi-quantitative food frequency questionnaire for nutritional education of patients of diabetes mellitus (FFQW65). Jpn J Public Health 47, 230244.
21. Adachi, M, Watanabe, M, Yamaoka, K et al. (2010) Validity and reproducibility of a food frequency questionnaire with 82-food items (FFQW82) for nutrition education. Jpn J Public Health 57, 475485.
22. Watanabe, M, Yamaoaka, K, Yokotsuka, M et al. (2003) Randomized controlled trial of a new dietary education program to prevent type 2 diabetes in a high-risk group of Japanese male workers. Diabetes Care 2, 32093214.
23. Adachi, M, Yamaoka, K, Watanabe, M et al. (2010) Effects of lifestyle education program for type 2 diabetes patients in clinics: study design of a cluster randomized trial. BMC Public Health 10, 742.
24. Adachi, M, Yamaoka, K, Watanabe, M et al. (2013) Effects of lifestyle education program for type 2 diabetes patients in clinics: a cluster randomized trial. BMC Public Health 13, 467.
25. Tango, T (2013) Statistics in Medicine, 3rd ed. Tokyo: Asakura Shoten Co., Ltd Press (in Japanese).
26. Peduzzi, P, Wittes, J, Detre, K et al. (1993) Analysis as-randomized and the problem of non-adherence: an example from the Veterans Affairs Randomized Trial of Coronary Artery Bypass Surgery. Stat Med 12, 11851195.
27. Schulz, KF, Altman, DG, Moher, D et al. (2010) CONSORT 2010 statement: updated guidelines for reporting parallel group randomized trials. BMJ 340, c332.
28. Wycherley, TP, Moran, LJ, Clifton, PM et al. (2012) Effects of energy-restricted high-protein, low-fat compared with standard-protein, low-fat diets: a meta-analysis of randomized controlled trials. Am J Clin Nutr 96, 12811298.
29. Salvado, JS, Ballart, JF, Ros, E et al. (2008) Effect of a Mediterranean diet supplemented with nuts on metabolic syndrome status. One-year results of the PREDIMED randomized trial. Arch Intern Med 168, 24492458.
30. Lindsay, JR, Mckillop, AM, Mooney, MH et al. (2003) Meal induced 24-hour profile of circulating glycated insulin in type 2 diabetic subjects measured by novel radioimmunoassay. Metabolism 52, 631635.
31. den Boer, AT, Herraets, IJT, Stegen, J et al. (2013) Prevention of the metabolic syndrome in IGT subjects in a lifestyle intervention: results from the SLIM study. Nutr Metab Cardiovasc Dis 23, 11471153.
32. Després, JP & Lemieux, I (2006) Abdominal obesity and metabolic syndrome. Nature 444, 881887.
33. Kadowaki, T, Yamauchi, T, Kubota, N et al. (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116, 17871792.
34. Hooper, L, Abdelhamid, A, Moore, HJ et al. (2012) Effect of reducing total fat intake on bodyweight: systematic review and meta-analysis of randomised controlled trials and cohort studies. BMJ 345, e7666.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
  • URL: /core/journals/public-health-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed