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Subclinical inflammation affects iron and vitamin A but not zinc status assessment in Senegalese children and Cambodian children and women

  • Marion Fiorentino (a1), Marlène Perignon (a1), Khov Kuong (a2), Chhoun Chamnan (a2), Jacques Berger (a1) and Frank T Wieringa (a1)...
  • Please note a correction has been issued for this article.
Abstract
Objective

To assess the impact of the acute-phase response (APR) during inflammation on Fe, Zn and vitamin A biomarkers to allow accurate evaluation of micronutrient status in populations.

Design

Ferritin (FER), soluble transferrin receptor (TfR), retinol-binding protein (RBP), Zn, α1-acid glycoprotein and C-reactive protein concentrations were measured. Correction factors (CF) for each biomarker were calculated as the ratio for groups at different stages of inflammation v. the reference group without inflammation.

Setting/Subjects

Senegalese (n 594) and Cambodian schoolchildren (n 2471); Cambodian women of reproductive age (n 2117).

Results

TfR was higher during the incubation phase (CF=1·17) and lower during early and late convalescence (CF=0·87 and 0·78). FER was higher during all phases (CF=0·83, 0·48 and 0·65, respectively). RBP was higher during incubation (CF=0·88) and lower during early convalescence (CF=1·21). No effect of inflammation on Zn status was found.

Conclusions

Inflammation led to overestimation of Fe status and underestimation of vitamin A status. The response of the biomarker for vitamin A status to inflammation depended on the vitamin A status of the populations. Surprisingly, the assessment of Zn status was hardly affected by inflammation. Different phases of the APR had opposite effects on the assessment of Fe status using TfR. More research is needed to define the correct methods to adjust for inflammation in nutritional studies.

Copyright
Corresponding author
* Corresponding author: Email marionfiorentino@hotmail.com
Footnotes
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The original version of this article was published with incorrect author affiliation information. A notice detailing this has been published and the error rectified in the online PDF and HTML copies.

Footnotes
References
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Public Health Nutrition
  • ISSN: 1368-9800
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