Skip to main content
×
×
Home

The SUN cohort study (Seguimiento University of Navarra)

  • Miguel Ángel Martínez-González (a1)
Abstract
Objective

Cohort study (the SUN project) to identify dietary determinants of hypertension, diabetes, obesity and coronary heart disease (CHD), among other conditions.

Design

The SUN project is a Mediterranean dynamic prospective follow-up (cohort) study assessing participants every 2 years. The recruitment started in 2000 and it is permanently open (this is a dynamic cohort). A preliminary case–control study of myocardial infarction was also conducted, selecting incident cases of myocardial infarction and matched hospital controls.

Setting

The SUN study is conducted in Spain with university graduates, most of them being former students of the University of Navarra. The case–control study was conducted in three tertiary hospitals in the city of Pamplona (Spain).

Subjects

The case–control study included 171 cases and 171 controls. We have currently enrolled more than 17 500 participants in the SUN cohort. Approximately 7500 of them were enrolled less than 2 years ago, and have not received yet the invitation to complete the 2-year follow-up assessment. The follow-up rate for the first 10 000 participants approaches 90%.

Results

The case–control study found inverse associations between olive oil (or adherence to a Mediterranean food pattern) and myocardial infarction. In the SUN cohort, after 28.5 months of follow-up a higher adherence to a Mediterranean food pattern rich in olive oil was associated with a reduced risk of hypertension, though the results were statistically significant only among men.

Conclusions

The SUN study and the accompanying case–control study support the benefits of a Mediterranean diet and olive oil against CHD and hypertension.

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      The SUN cohort study (Seguimiento University of Navarra)
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      The SUN cohort study (Seguimiento University of Navarra)
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      The SUN cohort study (Seguimiento University of Navarra)
      Available formats
      ×
Copyright
Corresponding author
*Corresponding author: E-mail mamartinez@unav.es
References
Hide All
1Willett, W. Nutritional Epidemiology. New York: Oxford University Press, 1998.
2Martínez-González, MA, Estruch, R. Mediterranean diet, antioxidants, and cancer: the need for randomised trials. European Journal of Cancer Prevention 2004; 13: 327–35.
3Jacques, PF, Tucker, KL. Are dietary patterns useful for understanding the role of diet in chronic disease? American Journal of Clinical Nutrition 2001; 73: 12.
4Hu, FB. Dietary pattern analysis: a new direction in nutritional epidemiology. Current Opinion in Lipidology 2002; 13: 39.
5Jacobs, DR Jr, Steffen, LM. Nutrients, foods, and dietary patterns as exposures in research: a framework for food synergy. American Journal of Clinical Nutrition 2003; 78(3 Suppl): 508S–13S.
6Martínez-González, MA, Sánchez-Villegas, A. The emerging role of Mediterranean diets in cardiovascular epidemiology: monounsaturated fats, olive oil, red wine or the whole pattern? European Journal of Epidemiology 2004; 19: 913.
7Trichopoulou, A, Costacou, T, Bamia, C, Trichopoulos, D. Adherence to a Mediterranean diet and survival in a Greek population. New England Journal of Medicine 2003; 348: 2599–608.
8Martín-Moreno, JM, Boyle, P, Gorgojo, L, Maisonneuve, P, Fernández-Rodríguez, JC, Salvini, S, et al. Development and validation of a food frequency questionnaire in Spain. International Journal of Epidemiology 1993; 22: 512–9.
9Martínez-González, MA, Sánchez-Villegas, A, De Irala, J, Martí, A, Martínez, JA. Mediterranean diet and stroke: objectives and design of the SUN project. Nutritional Neuroscience 2002; 5: 6573.
10Sánchez-Villegas, A, de Irala-Estévez, J, Martínez-González, MA, et al. Dieta Mediterránea y enfermedad cardiovascular: resultados del estudio piloto del proyecto SUN. Revista de Medicina de la Universidad de Navarra 2002; 46: 916.
11Sanchez-Villegas, A, Martínez, JA, De Irala, J, Martínez-González, MA. Determinants of the adherence to an ‘a priori’ defined Mediterranean dietary pattern. European Journal of Nutrition 2002; 41: 249–57.
12Sánchez-Villegas, A, Delgado-Rodriguez, M, Martínez-González, MA, De Irala-Estevez, J. Gender, age, socio-demographic and lifestyle factors associated with major dietary patterns in the Spanish Project SUN (Seguimiento Universidad de Navarra). European Journal of Clinical Nutrition 2003; 57: 285–92.
13Alonso, A, de, la, Fuente, C, Martin-Arnau, AM, de Irala, JMartinez, JA, Martinez-Gonzalez, MA. Fruit and vegetable consumption is inversely associated with blood pressure in a Mediterranean population with a high vegetable-fat intake: the Seguimiento Universidad de Navarra (SUN) study. British Journal of Nutrition 2004; 92: 311–9.
14Fernández-Jarne, E, Martínez-Losa, E, Prado-Santamaria, M, Brugarolas-Brufau, C, Serrano-Martínez, M, Martínez-González, MA. Risk of first non-fatal myocardial infarction negatively associated with olive oil consumption: a case–control study in Spain. International Journal of Epidemiology 2002; 31: 474–80.
15Fernández-Jarne, E, Alegre Garrido, F, Alonso Gutierrez, A, de La Fuente Arrillaga, C, Martínez-González, MA. Ingesta de ácidos grasos omega 3 y riesgo de infarto de miocardio: un estudio de casos y controles. Medicina Clinica 2002; 118: 121–5.
16Martínez-González, MA, Fernández-Jarne, E, Martínez-Losa, E, Prado-Santamaria, M, Brugarolas-Brufau, C, Serrano-Martínez, M. Role of fibre and fruit in the Mediterranean diet to protect against myocardial infarction: a case–control study in Spain. European Journal of Clinical Nutrition 2002; 56: 715–22.
17Martínez-González, MA, Fernández-Jarne, E, Serrano-Martínez, M, Marti, A, Martínez, JA, Martín-Moreno, JM. Mediterranean diet and reduction in the risk of a first acute myocardial infarction: an operational healthy dietary score. European Journal of Nutrition 2002; 41: 153–60.
18Hernandez-Diaz, S, Martínez-Losa, E, Fernández-Jarne, E, Serrano-Martínez, M, Martínez-González, MA. Dietary folate and the risk of nonfatal myocardial infarction. Epidemiology 2002; 13: 700–6.
19Martínez-González, MA, Alonso, A, Fernández-Jarne, E, de Irala, J. What is protective in the Mediterranean diet? Atherosclerosis 2003; 166: 405–7.
20Alonso, A, Fernández-Jarne, E, Serrano-Martínez, M, Martínez-González, MA. Fish and shellfish consumption in relation to death from myocardial infarction among men in Shanghai China. American Journal of Epidemiology 2003; 157: 85.
21Fernández-Jarne, E, Martínez-Losa, E, Serrano-Martínez, M, Prado-Santamaria, M, Brugarolas-Brufau, C, Martínez-González, MA. Type of alcoholic beverage and first acute myocardial infarction: a case–control study in a Mediterranean country. Clinical Cardiology 2003; 26: 313–8.
22Barzi, F, Woodward, M, Marfisi, RM, Tavazzi, L, Valagussa, F, Marchioli, R. GISSI-Prevenzione Investigators. Mediterranean diet and all-causes mortality after myocardial infarction: results from the GISSI-Prevenzione trial. European Journal of Clinical Nutrition 2003; 57 604–11. Erratum in: European Journal of Clinical Nutrition 2003; 57: 1034.
23Chasan-Taber, S, Rimm, EB, Stampfer, MJ, Spiegelman, D, Colditz, GA, Giovannucci, E, et al. Reproducibility and validity of a self-administered physical activity questionnaire for male health professionals. Epidemiology 1996; 7: 81–6.
24Ainsworth, BE, Haskell, WL, Whitt, MC, Irwin, ML, Swartz, AM, Strath, SJ, et al. Compendium of physical activities: an update of activity codes and MET intensities. Medicine and Science in Sports and Exercise 2000; 32: S498S504.
25Martínez-González, MA, Varo, JJ, Santos, JL, De Irala, J, Gibney, M, Kearney, J, et al. Prevalence of physical activity during leisure time in the European Union. Medicine and Science in Sports and Exercise 2001; 33: 1142–6.
26Panagiotakos, DB, Pitsavos, C, Chrysohoou, C, Stefanadis, C, Toutouzas, P. Risk stratification of coronary heart disease in Greece: final results from the CARDIO2000 epidemiological study. Preventive Medicine 2002; 5: 548–56.
27Alonso, A, Ruiz-Gutierrez, V, Martínez-González, MA. Monounsaturated fatty acids, olive oil and blood pressure: epidemiological, clinical and experimental evidences. Public Health Nutrition 2006; in press.
28Alonso, A, Beunza, JJ, Delgado-Rodriguez, M, Martinez-Gonzalez, MA. Validation of self reported diagnosis of hypertension in a cohort of university graduates in Spain. BMC Public Health 2005; 5: 94.
29Martinez-Gonzalez, MA, Fernandez-Jarne, E, Serrano-Martinez, M, Wright, M, Gomez-Gracia, E. Development of a short dietary intake questionnaire for the quantitative estimation of adherence to a cardioprotective Mediterranean diet. European Journal of Clinical Nutrition 2004; 58: 1550–2.
30Alonso, A, Martinez-Gonzalez, MA. Olive oil consumption and reduced incidence of hypertension: the SUN study. Lipids 2004; 39: 1233–8.
31Psaltopoulou, T, Naska, A, Orfanos, P, Trichopoulos, D, Mountokalakis, T, Trichopoulou, A. Olive oil, the Mediterranean diet, and arterial blood pressure: the Greek European Prospective Investigation into Cancer and Nutrition (EPIC) study. American Journal of Clinical Nutrition 2004; 80: 1012–8.
32Ferrara, LA, Raimondi, S, D'Episcopo, l, Guilda, l, Dello Russo, A, Marotta, T. Olive oil and reduced need for antiyhypertensive medications. Archives of Internal Medicine 2000; 160: 837–42.
33Appel, LJ, Sacks, FM, Carey, VJ, Obarzanek, E, Swain, JF, Miller, ER 3rd, et al. Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart Randomized Trial. Journal of the American Medical Association 2005; 294: 2455–64.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

Public Health Nutrition
  • ISSN: 1368-9800
  • EISSN: 1475-2727
  • URL: /core/journals/public-health-nutrition
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed