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An Immunochemical Approach to Model and Long-Term Suppression of Depressive and Anxiety Behavior

Published online by Cambridge University Press:  10 April 2014

Igor P. Ashmarin ,
Raisa A. Danilova ,
Olga I. Rud'ko ,
Maria V. Belopolskaya ,
Maria F. Obukhova  and
Elena V. Shmalgausen
Igor P. Ashmarin*
Affiliation:
Moscow State University
Raisa A. Danilova
Affiliation:
Moscow State University
Olga I. Rud'ko
Affiliation:
Moscow State University
Maria V. Belopolskaya
Affiliation:
Moscow State University
Maria F. Obukhova
Affiliation:
Moscow State University
Elena V. Shmalgausen
Affiliation:
Moscow State University
*
Correspondence concerning this article should be addressed to: Igor P. Ashmarin, Dept. of Human Physiology, School of Biology, Moscow State University, Vorobiovy Gory, Moscow, 119922, Russia. FAX: (095) 939 33 55. E-mail: ashmarin25@mail.ru
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Abstract

The inhibitor of monoaminooxydase isatin and the ligand of B-receptors cholecystokinin-4 play a significant role in the suppression and induction of depressive and anxiety states. We induced the formation of auto-antibodies to these compounds against their conjugates with antigen-carrier by immunization of white rats. The result was long-term (more than 2 months) stimulation of depressive and anxiety behavior after immunization to isatin and, in contrast, the suppression of such behavior after immunization to cholecystokinin. The perspective of immunochemical approach to long-term correction of behavior is discussed.

El inhibidor de la monoaminooxidasa isatin y el ligando de B-receptores colecistokinina-4 juegan un papel significativo en la supresión e inducción de los estados de ansiedad y depresión. Nosotros hemos inducido la formación de auto-anticuerpos contra estas sustancias mediante la inmunización de ratas blancas. El resultado fue la estimulación prolongada (más de 2 meses) de conducta depresiva y de ansiedad tras la inmunización con isatin y, por el contrario, la supresión de esta conducta después de la inmunización con colecistokinina. En el artículo se discute la posibilidad de la corrección de la conducta a largo plazo mediante la manipulación immunoquímica.

Keywords

Depressionmodelingimmuno-correctionactive immunizationcholecystokinin-4isatinbiogenic aminesrats.Depresiónremodelaciónimmuno-correccióninmunización activacolecistokinina-4isatinaminas biogénicasratas.
Type
Articles
Information
The Spanish Journal of Psychology , Volume 9 , Issue 2 , November 2006 , pp. 219 - 227
Copyright
Copyright © Cambridge University Press 2006

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