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Population-based study of the prevalence and presentation of dementia in adults with Down's syndrome

Published online by Cambridge University Press:  03 January 2018

Anthony J. Holland
Affiliation:
Section of Developmental Psychiatry, Department of Psychiatry, University of Cambridge
Johnny Hon
Affiliation:
Section of Developmental Psychiatry, Department of Psychiatry, University of Cambridge
Felicia A. Huppert
Affiliation:
Department of Psychiatry, University of Cambridge
Fran Stevens
Affiliation:
Section of Developmental Psychiatry, Department of Psychiatry, University of Cambridge
Peter Watson
Affiliation:
Applied Psychology Unit, Cambridge

Abstract

Background

The reported prevalence rates of dementia in people with Down's syndrome have varied considerably across studies. The aim of this study was to investigate the extent of clinical change with age using an established diagnostic instrument in an unbiased, population-based sample of older people with Down's syndrome.

Method

Changes in memory, personality, general mental functioning and daily living skills were assessed using a modified version of the informant interview of the Cambridge Examination for Mental Disorders of the Elderly (CAMDEX).

Results

Age-specific prevalence rates of dementia varied according to the diagnostic criteria used. Using CAMDEX criteria for Alzheimer's disease, prevalence rates increased from 3.4 to 10.3 to 40% in the 30–39, 40–49 and 50–59 age group, respectively.

Conclusions

Overall, the age-related pattern of presentation and dementia diagnoses differs from that seen in the general elderly population. However, age-specific prevalence rates of Alzheimer's disease were similar but 30–40 years earlier in life.

Type
Papers
Copyright
Copyright © 1998 The Royal College of Psychiatrists 

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References

Allsop, D. Kidd, M. Landon, M. et al (1984) Isolated senile plaque cores in Alzheimer's disease and Down's syndrome show differences in morphology. Journal of Neurology, Neurosurgery and Psychiatry, 49, 886892.CrossRefGoogle ScholarPubMed
American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders (4th edn) (DSM–IV). Washington. DC: APA.Google ScholarPubMed
Aylward, E. H. Burt, D. B. Thorpe, L. U. et al (1997) Diagnosis of dementia in individuals with intellectual disability. Journal of Intellectual Disability Research, 41, 152164.CrossRefGoogle ScholarPubMed
Crome, L. & Stern, J. (1972) Pathology of Mental Retardation. Baltimore, MD: Williams and Wilkins.Google ScholarPubMed
Gregory, C. A. & Hodges, J. R. (1996) Clinical features of frontal lobe dementia in comparison to Alzheimer's disease. Journal of Neural Transmitters, 47 (suppl). 103123.Google ScholarPubMed
Haveman, M. J. Maaskant, M. A. & Sturmans, F. (1989) Older Dutch residents of institutions, with and without Down syndrome: comparison of mortality and morbidity trends and motor/social functioning. Australia and New Zealand Journal of Developmental Disabilities, 15, 241255.CrossRefGoogle Scholar
Haxby, J. V. (1989) Neuropsychological evaluation of adults with Down's syndrome: patterns of selective impairment in non-demented old adults. Journal of Mental Deficiency Research, 33, 193210.Google ScholarPubMed
Holland, A. J. & Oliver, C. (1995) Down's syndrome and the links with Alzheimer's disease. Journal of Neurology, Neurosurgery and Psychiatry, 59, 111114.CrossRefGoogle ScholarPubMed
Kemper, T. L. (1988) Neuropathology of Down's syndrome. In The Psychobiology of Down Syndrome (ed. L. Nadel). Cambridge, MA: MIT Press.Google Scholar
Lai, F. & Williams, R. (1989) A prospective study of Alzheimer's disease in Down's syndrome. Archives of Neurology, 46, 849853.CrossRefGoogle Scholar
Mann, D. M. A. Yates, P. O. Marcyniuk, B. et al (1986) The topography of plaques and tangles in Down's syndrome patients of different ages. Neuropathology and Applied Neurobiobgy, 12, 447457.CrossRefGoogle ScholarPubMed
Mann, D. M. A. & Esiri, M. M. (1989) The pattern of acquisition of plaques and tangles in Down's syndrome patients under 50 years of age. Journal of Neurological Science, 89, 169179.CrossRefGoogle ScholarPubMed
McKeith, I. G. Perry, R. H. Jabeen, S. et al (1992) Operational criteria for senile dementia of Lewy body type (SDLT). Psychological Medicine, 2, 911922.CrossRefGoogle Scholar
McNemar, Q. (1955) Psychological Statistics. New York: Wiley.Google Scholar
Roth, M. Tym, E. Mountjoy, C. Q. et al (1986) CAMDEX – A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. British Journal of Psychiatry, 149, 698709.CrossRefGoogle Scholar
Sparrow, S. S. Balla, D. A. & Cicchetti, D. V. (1984) Vineland Adaptive Behavior Scale (Interview Edition-Survey Version). Circles Pines, MN: American Guidance Association.Google Scholar
Thase, M. E. Tigner, R. Smeitzer, D. et al (1984) Age-related neuropsychological deficits in Down's syndrome. Biological Psychiatry, 19, 571585.Google ScholarPubMed
Winiewski, K. E. Winiewski, H. M. & Wen, G. Y. (1985) Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Annals of Neurology, 17, 278282.CrossRefGoogle Scholar
World Health Organization (1992) The Tenth Revision of the International Classification of Diseases and Related Health Problems (ICD–10). Geneva: WHO.Google ScholarPubMed
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