Abi-Dargham, A., Krystal, J. H., Anjilvel, S., et al (1998) Alterations of benzodiazepine receptors in type II alcoholic subjects measured with SPECT and [123I]iomazenil. American Journal of Psychiatry, 155, 1550–1555.
Bailey, J. E., Potokar, J., Caupland, N. J., et al (1995) The 5-HT3 antagonist ondansetron reduces gastrointestinal side effects induced by a specific serotonin re-uptake inhibitor in man. Journal of Psychopharmacology, 9, 137–141.
Cloninger, C. R. (1987) Neurogenetic adaptive mechanisms in alcoholism. Science, 236, 410–416.
Collingridge, G. L. & Bliss, T. V. P. (1995) Memories of NMDA receptors and LTP. Trends in Neuroscience, 18, 54–56.
Cowley, D. S., Roy-Byrne, P. P., Godon, C., et al (1992) Response to diazepam in sons of alcoholics. Alcoholicism: Clinical and Experimental Research, 16, 1057–1063.
George, D. T., Benkelfat, C., Rawlings, R. R., et al (1997) Behavioral and neuroendocrine responses to m-chlorophenylpiperazine in subtypes of alcoholics and in healthy comparison subjects. American Journal of Psychiatry, 154, 81–87.
Gilman, S., Koeppe, R. A., Adams, K., et al (1996) Positron emission tomographic studies of cerebral benzodiazepine-receptor binding in chronic alcoholics. Annals of Neurology, 40, 163–171.
Glue, P. W. & Nutt, D. (1990) Overexcitement and disinhibition. Dynamic neurotransmitter interactions in alcohol withdrawal. British Journal of Psychiatry, 157, 491–499.
Heinz, A., Ragan, P., Jones, D. W., et al (1998) Reduced central serotonin transporters in alcoholism. American Journal of Psychiatry, 155, 1544–1549.
Higley, J. D.
Soumi, S. J. & Linnoila, M. (1996) A nonhuman primate model of Type II excessive alcohol consumption? Part I. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations and diminished social competence correlate with excessive alcohol consumption. Alcoholism: Clinical and Experimental Research, 20, 629–642.
Jackson, H. C. & Nutt, D. J. (1995) Inverse agonists and alcohol. In Inverse Agonists (eds M. Sarter, D. J. Nutt & R. Lister), pp. 113–138. New York: John Wiley & Sons.
Johnson, B. A., Campling, G. M., Griffiths, P., et al (1993) Attenuation of some alcohol-induced mood changes and the desire to drink by 5-HT3 receptor blockage: a preliminary study in healthy male volunteers, Psychopharmacology, 112, 142–144.
Kranzler, H. R., Burleson, J. A., Del Boca, F. K., et al (1994) Buspirone treatment of anxious alcoholics. Archives of General Psychiatry, 51, 720–731.
Lamparski, D. M., Roy, A., Nutt, D. J., et al (1991) The criteria of Cloninger et al. and von Knorring et al. for subgrouping alcoholics: a comparison in a clinical population. Acta Psychiatrica Scandinavica, 84, 497–502.
Lingford-Hughes, A. R., Action, P. D., Gacinovic, S., et al (1998) Reduced levels of GABA–benzodiazepine receptor in alcohol dependency in the absence of grey matter atrophy. British Journal of Psychiatry, 173, 116–122.
Little, H. J. (1991) The role of neuronal calcium channels in dependence on ethanol and other sedatives/hypnotics. Pharmacological Therapy, 50, 347–365.
Littleton, J. M. (1995) Acamprosate in alcohol dependence: how does it work?
Addiction, 90, 1179–1188.
Lovinger, D. M., White, G. & Weight, F. F. (1989) Ethanol inhibits NMDA activated ion currents in hippocampal neurones. Science, 243, 1721–1724.
Luddens, H., Pritchett, D. B., Kohier, M., et al (1990) Cerebellar GABA receptor selective for a behavioural alcohol antagonist. Nature, 346, 648–651.
Luddens, , & Korpi, E. R. (1995) Biological function of GABA-A/benzodiazepine receptor heterogeneity. Journal of Psychiatry Research, 29, 77–94.
Mhatre, M., Mehta, A. K. & Ticku, M. K. (1988) Chronic ethanol administration increases the binding of the benzodiazepine inverse agonist and alcohol antagonist (3H) Ro 15-4513 in rat brain. European Journal of Pharmacology, 153, 141–145.
Nutt, D. (1993) Neurochemistry and neuropharmacology. In Seminars in Basic Neurosciences (eds Morgan, G. & Butler, S.), pp. 71–111. London: Royal College of Psychiatrists.
Nutt, D. (1996) Addiction: brain mechanisms and their treatment implications. Lancet, 347, 31–36.
Nutt, D., Adinoff, B. & Linnioila, M. (1988) Benzodiazepinesin the treatment of alcoholism. In Advances in Alcoholism VII (ed. Gallanter, M.), pp. 283–313. New York: Plenum.
Nutt, D., & Peters, T. J. (1994) Alcohol: the drug. British Medical Bulletin (special issue: Alcohol and Alcohol Problems), 50, 5–17.
O'Malley, S. S., Jaffe, A. J., Chang, G., et al (1993) Naltrexone and coping skills therapy for alcohol dependence: a controlled study. Archives of General Psychiatry, 49, 881–887.
Ritzmann, R. F. & Tabalcoff, B. (1976) Dissociation of alcohol tolerance and dependence. Nature, 243, 418–420.
Sass, H., Soyka, M., Mann, K., et al (1996) Relapse prevention by acamprosate: results from a placebo-controlled study on alcohol dependence. Archives of General Psychiatry, 53, 673–680.
Sellers, E. M., Toneatto, T., Romach, M. K., et al (1994) Clinical efficacy of the 5-HT3 antagonist ondansetron in alcohol abuse and dependence. Alcoholism: Clinical and Experimental Research, 18, 879–885.
Shaw, G. K., Waller, S., Majumdar, S. K., et al (1994) Tiapride in the prevention of relapse in recently detoxified alcoholics. British Journal of Psychiatry, 165, 515–523.
Signs, S. A. & Schechter, M. D. (1988) The role of dopamine and serotonin receptors in the mediation of the ethanol interoceptive cue. Pharmacology Biochemistry and Behaviour, 30, 55–64.
Ticku, M. K., Mhatre, M. & Mehta, A. K. (1992) Modulation of GABAergic transmission by ethanol. In Advances in Biochemical Psychopharmacology: GABAergic Synaptic Transmission – Molecular, Pharmacological and Clinical Aspects (eds Biggio, G., Concas, A. & Costa, E.), pp. 255–268. New York: Raven Press.
Ulm, R. R., Volpicelli, J. R. & Volpicelli, L. A. (1995) Opiates and alcohol self-administration in animals. Journal of Clinical Psychiatry, 56, 5–14.
Virkunnen, M., Rawlings, R., Tolcola, R., et al (1994) CSF biochemistries, glucose metabolism and diurnal activity rhythms in alcoholic, violent attenders, fire setters and healthy volunteers. Archives of General Psychiatry, 51, 20–27.
Volkow, N. D., Wang, G.-J., Hitzemann, R., et al (1993) Decreased cerebral response to inhibitory neurotransmission in alcoholics. American Journal of Psychiatry, 150, 417–422.
Volkow, N. D., Wang, G.-J., Beglelter, H., et al (1995) Regional brain metabolic response to lorazepam in subjects at risk for alcoholism. Alcoholism: Clinical and Experimental Research, 19, 510–516.
Volpicelli, J. R., Alterman, A. I., Hayashida, M., et al (1993) Naltrexone in the treatment of alcohol dependence. Archives of General Psychiatry, 49, 876–880.
Volpicelli, J. R., Rhines, K. C., Rhines, J. S., et al (1997) Naltrexone and alcohol dependence: role of subject compliance. Archives of General Psychiatry, 54, 737–742.
Von Knorring, A. L., Bohman, M., Von Knorring, L., et al (1985) Platelet MAO activity as a biological marker in subgroups of alcoholism. Acta Psychiatrica Scandinavica, 72, 51–58.
Wafford, K. A., & Whiting, P. J. (1992) Ethanol potentiation of GABAA receptors requires phosphorylation of the alternatively spliced variant of the gamma-2 subunit. FEBS Letters, 313, 113–117.
Weight, F. F., Peoples, R. W., Wright, J. M., et al (1993) Ethanol action on excitatory amino acid activated ion channels. In Advances in Biomedical Alcoholism Research (eds Taberner, P. V. & Badawy, A. A.). Oxford: Pergamon Press.
Wolfe, S. M. & Victor, M. (1969) The relationship of hypomagnesaemia and alkalosis to alcohol withdrawal symptoms. Annals of the New York Academy of Sciences, 162, 973–984.