Skip to main content

The Association Between Triple X and Psychosis

  • Wendy J. Woodhouse (a1), Anthony J. Holland (a2), Greg McLean (a3) and Adrianne M. Reveley (a4)

Two cases of psychotic illness in association with the karyotype triple X showed specific diagnostic and management problems as well as obstetric complications, EEG abnormalities, and lack of a family history of psychiatric disorder. Routine karyotyping during the investigation of psychosis is becoming relevant to psychiatric practice as research reports increasingly feature genetic and chromosome anomalies in association with schizophrenic psychoses.

British Journal of Psychiatry (1992), 160, 554–557

Corresponding author
Hide All
American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders (3rd edn, revised) (DSM–III–R). Washington, DC: APA.
Bassett, A. S., McGilliveray, B. C., Jones, B. D., et al (1988) Partial trisomy chromosome 5 cosegregating with schizophrenia. Lancet, i, 799800.
Crow, T. J. (1990) The continuum of psychosis and its genetic origins. British Journal of Psychiatry, 156, 788797.
Eagles, J. M., Gibson, I., Bremner, M. H., et al (1990) Obstetric complications in DSM–III schizophrenics and their siblings. Lancet, 335, 11391141.
Gershon, E. S., Targum, S. D., Mathysse, S., et al (1979) Colour blindness not closely linked to bipolar illness. Archives of General Psychiatry, 36, 14231430.
Gualtieri, C. T., Alexandra Adams, D. S. & Loiselle, D. (1982) Minor physical anomalies in alcoholic and schizophrenic adults and hyperactive and autistic children. American Journal of Psychiatry, 139, 540643.
Holland, A. J. & Godsen, C. (1990) A balanced chromosomal translocation partially co-segregating with psychotic illness in a family. Psychiatric Research, 32, 18.
Johnstone, E. C., Crow, T. J., Frith, C. D., et al (1976) Cerebral ventricle size and cognitive impairment in chronic schizophrenia. Lancet, ii, 924926.
Kidd, C. B., Knox, R. S., Mantle, D. J. (1963) A psychiatric investigation of triple-X chromosome females. British Journal of Psychiatry, 109, 9094.
Olanders, S. (1967) Double barr bodies in women in mental hospitals. British Journal of Psychiatry, 113, 10971099.
Polani, P. E. (1977) Abnormal sex chromosomes, behaviour and mental disorder. In Developments in Psychiatric Research (ed. Tanner, J. M.), pp. 89128. London: Hodder & Stoughton.
St Clair, D., Blackwood, D., Muir, W., et al (1990) Association within a family of a balanced autosomal translocation with major mental illness. Lancet, 336, 1316.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *


Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

The Association Between Triple X and Psychosis

  • Wendy J. Woodhouse (a1), Anthony J. Holland (a2), Greg McLean (a3) and Adrianne M. Reveley (a4)
Submit a response


No eLetters have been published for this article.


Reply to: Submit a response

Your details

Conflicting interests

Do you have any conflicting interests? *