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Cognitive dysfunction in first-episode psychosis: the processing speed hypothesis

  • José Manuel Rodríguez-Sánchez (a1), Benedicto Crespo-Facorro (a1), Cesar González-Blanch (a1), Rocío Pérez-Iglesias (a1), José Luis Vázquez-Barquero (a1) and PAFIP Group Study...
Abstract
Background

Speed of processing is a cognitive process underlying cognitive dysfunction in people with chronic schizophrenia

Aims

To investigate the contribution of speed of processing to the cognitive deficits observed in a representative large sample with first-episode schizophrenia

Method

People with a diagnosis of first-episode schizophrenia-spectrum disorders (n=26) and healthy controls (n=28) were compared on several cognitive measures before and after controlling for speed of processing

Results

Before controlling for speed of processing, patients and controls differed significantly on all cognitive measures. All significant differences in cognitive functioning disappeared when the result of the Digital Symbol Substitution Test was included as an additional covariate

Conclusions

Speed of information processing may be considered a core cognitive deficit in schizophrenia and might be mediating a broader diversity of cognitive disturbances

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Copyright
Corresponding author
Professor Benedicto Crespo-Facorro, Department of Psychiatry, Hospital Universitario Marquees de Valdecilla, Planta 2a, Edificio 2 de Novembre, Avda, Valdecilla s/n, 39008, Santander, Spain. E-mail: bcfacorro@humv.es
Footnotes
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*

Paper presented at the Early Phase of Psychosis – Research and Treatment Conference, London, April 2006.

Declaration of interest

None.

Funding detailed in Acknowledgements.

Footnotes
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Cognitive dysfunction in first-episode psychosis: the processing speed hypothesis

  • José Manuel Rodríguez-Sánchez (a1), Benedicto Crespo-Facorro (a1), Cesar González-Blanch (a1), Rocío Pérez-Iglesias (a1), José Luis Vázquez-Barquero (a1) and PAFIP Group Study...
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