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Cognitive performance in presumed obligate carriers for psychosis

  • Timothea Toulopoulou (a1), Francesca Mapua-Filbey (a1), Seema Quraishi (a1), Eugenia Kravariti (a1), Robin G. Morris (a2), Colm McDonald (a3), Muriel Walshe (a3), Elvira Bramon (a3) and Robin M. Murray (a3)...
Summary

We report cognitive performance of a group of individuals who are likely to have transmitted liability to psychosis to their offspring. Out of 230 relatives of patients with psychosis, 27 met our criteria for a presumed obligate carrier, that is a non-psychotic individual who had a parent or a sibling as well as an offspring with psychosis. The presumed obligate carriers showed impairments in verbal memory and in visuospatial manipulations, suggesting that these individuals transmit vulnerability for psychosis to their offspring in terms of a disability to recall verbal information and an impaired capacity to perceive spatial relations.

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Copyright
Corresponding author
Dr Timothea Toulopoulou, Section of General Psychiatry Box 63, Division of Psychological Medicine, Institute of Psychiatry De Crespigny Park, London SE5 8AF, UK. Tel: +44(0) 207 848 0061; fax: +44(0)207 701 9044; e-mail: t.toulopoulou@iop.kcl.ac.uk
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Declaration of interest

None. Funding detailed in Acknowledgements.

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References
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Toulopoulou, T., Rabe-Hesketh, S., King, H., et al (2003b) Episodic memory in schizophrenic patients and their relatives Schizophrenia Research, 63, 261271.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Cognitive performance in presumed obligate carriers for psychosis

  • Timothea Toulopoulou (a1), Francesca Mapua-Filbey (a1), Seema Quraishi (a1), Eugenia Kravariti (a1), Robin G. Morris (a2), Colm McDonald (a3), Muriel Walshe (a3), Elvira Bramon (a3) and Robin M. Murray (a3)...
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