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Cyproheptadine Treatment in Neuroleptic-Induced Akathisia

  • David Weiss (a1), Dov Aizenberg (a1), Haggai Hermesh (a1), Zvi Zemishlany (a1), Hanan Munitz (a1), Margaret Radwan (a1) and Abraham Weizman (a2)...

Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic-induced akathisia.


In an open clinical trial 17 neuroleptic-treated patients with akathisia were administered cyproheptadine (16 mg/day) over 4 days. Assessment of akathisia, psychosis and depression were monitored by BAS, BPRS and HAM-D.


All subjects showed improvement in the severity of akathisia, which in the majority (15/17) was of a marked degree. There was no aggravation of psychosis or depression. Symptoms of akathisia returned when cyproheptadine was discontinued.


Cyproheptadine may be useful in neuroleptic-induced akathisia.

Corresponding author
Dr Dov Aizenberg, Gehah Psychiatric Hospital, Beilinson Medical Center, PO Box 102, Petah Tiqva 49 100, Israel
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Cyproheptadine Treatment in Neuroleptic-Induced Akathisia

  • David Weiss (a1), Dov Aizenberg (a1), Haggai Hermesh (a1), Zvi Zemishlany (a1), Hanan Munitz (a1), Margaret Radwan (a1) and Abraham Weizman (a2)...
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