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A Danish Twin Study of Manic-Depressive Disorders

  • A. Bertelsen (a1), B. Harvald (a2) and M. Hauge (a3)

The existence of a nation-wide twin register and central psychiatric register has made possible a catamnestic investigation of an unselected and representative sample of twins with manic-depressive disorders.

From a total population of 11,288 same-sexed twin pairs born 1870–1920 in Denmark 126 probands from no pairs were ascertained. Among the co-twins of 69 monozygotic probands there were found 46 with manic-depressive disorders, and a further 14 had presented other psychoses or marked affective personality disorders or had committed suicide, yielding a proband rate of strict concordance, C1 = 0·67 and of broad, partial concordance, C2 = 0·87. The corresponding direct pairwise concordance rates were 32/55 = 0·58 and 46/55 = 0·84 respectively. For the dizygotic twins the proband concordance rate of C1 was 11/54 = 0·20 and of C2 20/54 = 0·37, and the direct pairwise rates were 9/52 = 0·17 and 18/52 = 0·35 respectively. The differences between the pairwise rates for the monozygotic and dizygotic twins are significant (P < 0·001 at χ2 analysis). This finding is in accordance with previous twin studies of manic-depressive disorders and confirms the evidence of a strong genetic factor. The concordance with respect to unipolar and bipolar forms was not in contradiction to recent evidence of a genetic difference between the bipolar and unipolar form, the latter probably related to the female sex.

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Allen, G., Harvald, B. & Shields, J. (1967) Measures of twin concordance. Acta Genetica et Statistica Medica, 17, 475–81.
Allen, M. G., Cohen, S., Pollin, W. & Greenspan, S. I. (1974) Affective illness in veteran twins. A diagnostic review. American Journal of Psychiatry, 131, 1234–9.
Angst, J. (1966) Zur Ätiologie und Nosologie endogener depressiven Psychosen. Monographien aus dem Gesamtgebiete der Neurologie und Psychiatric, Heft 112. Berlin: Springer.
Dupont, A., Videbech, Th. & Weeke, A. (1974) A cumulative national psychiatric register: Its structure and application. Acta Psychiatrica Scandinavica, 50, 161–73.
Essen-Möller, E. (1941) Psychiatrische Untersuchungen an einer Serie von Zwillingen. Copenhagen: Munksgaard.
Da Fonseca, A. F. (1959) Análise Heredo-clínica das Perturbanções Afectivas. Oporto (cited by Zerbin-Rüdin, 1969).
Fischer, M. (1973) Genetic and Environmental Factors in Schizophrenia. A Study of Schizophrenic Twins and their Families. Copenhagen: Munksgaard.
Fremming, K. H. (1947) Morbid Risk of Mental Diseases and Other Mental Abnormalities in an Average Danish Population. Copenhagen: Munksgaard.
Hauge, M., Harvald, B., Fischer, M., Gotlieb Jensen, K., Juel-Nielsen, N., Raebild, I., Shapiro, R. & Videbech, Th. (1968) The Danish Twin Register. Acta Geneticae Medicae et Gemellologiae, 17, 315–32.
Juel-Nielsen, N. & Videbech, Th. (1970) A twin study of suicide. Acta Geneticae Medicae et Gemellologiae, 19, 307–10.
Kallmann, F. J. (1954) Genetic principles in manic-depressive psychosis. In Depression (eds Hoch, P. and Zubin, J.), pp 124. New York: Grune & Stratton.
Kallmann, F. J., De Porte, J., De Porte, E. & Feingold, L. (1949) Suicide in twins and only children. American Journal of Human Genetics, 1(2), 113–26.
Kringlen, E. (1967) Heredity and Environment in the Functional Psychoses. Oslo: Universitets-Forlaget.
Kraepelin, E. (1913) Psychiatric, VIII Auflage. Leipzig: Barth.
Leonhard, K. (1959) Aufteilung der endogenen Psychosen. Berlin: Akademie-Verlag.
Luxenburger, H. (1928) Vorläufiger Bericht über psychiatrische Serienuntersuchungen von Zwillingen. Zeitschrift für die Gesamte Neurologic und Psychiatric, 116, 296326.
Perris, C. (1966) A study of bipolar (manic-depressive) and unipolar recurrent depressive psychoses. Acta Psychiatrica Scandinavica, Suppl 194.
Perris, C. (1973) The genetics of affective disorders. In Biological Psychiatry (ed. Mendels, J.), pp 383415. New York: Wiley & Sons.
Price, J. (1968) The genetics of depressive behaviour. In Recent Developments in Affective Disorders—A Symposium (eds Coppen, A. and Walk, A.), pp 3754. British Journal of Psychiatry Special Publication No. 2. Royal Medico-Psychological Association.
Rosanoff, A. J., Handy, L. M. & Plesset, I. R. (1934) The etiology of manic-depressive syndromes with special reference to their occurrence in twins. American Journal of Psychiatry, 91, 725–62.
Sainsbury, P. (1968) Suicide and depression. In Recent Developments in Affective Disorders—A Symposium (eds Coppen, A. and Walk, A.), pp 113. British Journal of Psychiatry Special Publication No. 2. Royal Medico-Psychological Association.
Shapiro, R. W. (1970) A Twin Study of Non-Endogenous Depression. Copenhagen: Munksgaard.
Slater, E. (1953) Psychotic and Neurotic Illnesses in Twins. M.R.C. Special Report Series No. 278. London: HMSO.
Slater, E. & Cowie, V. (1971) The Genetics of Mental Disorders, pp 353–4. London: Oxford University Press.
Zerbin-Rüdin, E. (1969) Zur Genetik der depressiven Erkrankungen. In Das Depressive Syndrom (eds Hippius, H. and Selbach, H.), pp 3756. Berlin: Urban & Swartzenberg.
Winokur, G. (1972) Types of depressive illness. British Journal of Psychiatry, 120, 265–6.
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A Danish Twin Study of Manic-Depressive Disorders

  • A. Bertelsen (a1), B. Harvald (a2) and M. Hauge (a3)
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