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Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder

  • Lukas Propper (a1), Jill Cumby (a2), Victoria C. Patterson (a2), Vladislav Drobinin (a2), Jacqueline M. Glover (a2), Lynn E. MacKenzie (a2), Jessica Morash-Conway (a2), Sabina Abidi (a1), Alexa Bagnell (a1), David Lovas (a1), Tomas Hajek (a3), William Gardner (a4), Kathleen Pajer (a5), Martin Alda (a3) and Rudolf Uher (a6)...
Abstract
Background

It has been suggested that offspring of parents with bipolar disorder are at increased risk for disruptive mood dysregulation disorder (DMDD), but the specificity of this association has not been established.

Aims

We examined the specificity of DMDD to family history by comparing offspring of parents with (a) bipolar disorder, (b) major depressive disorder and (c) a control group with no mood disorders.

Method

We established lifetime diagnosis of DMDD using the Schedule for Affective Disorders and Schizophrenia for School Aged Children for DSM-5 in 180 youth aged 6–18 years, including 58 offspring of parents with bipolar disorder, 82 offspring of parents with major depressive disorder and 40 control offspring.

Results

Diagnostic criteria for DMDD were met in none of the offspring of parents with bipolar disorder, 6 of the offspring of parents with major depressive disorder and none of the control offspring. DMDD diagnosis was significantly associated with family history of major depressive disorder.

Conclusions

Our results suggest that DMDD is not specifically associated with a family history of bipolar disorder and may be associated with parental depression.

Copyright
Corresponding author
Rudolf Uher, 5909 Veterans' Memorial Drive, B3H 2E2, Halifax, Nova Scotia, Canada. Email: uher@dal.ca
Footnotes
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Declaration of interest

None.

Footnotes
References
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Disruptive mood dysregulation disorder in offspring of parents with depression and bipolar disorder

  • Lukas Propper (a1), Jill Cumby (a2), Victoria C. Patterson (a2), Vladislav Drobinin (a2), Jacqueline M. Glover (a2), Lynn E. MacKenzie (a2), Jessica Morash-Conway (a2), Sabina Abidi (a1), Alexa Bagnell (a1), David Lovas (a1), Tomas Hajek (a3), William Gardner (a4), Kathleen Pajer (a5), Martin Alda (a3) and Rudolf Uher (a6)...
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