Jääskeläinen, E, Juola, P, Hirvonen, N, McGrath, JJ, Saha, S, Isohanni, M, et al. A systematic review and meta-analysis of recovery in schizophrenia. Schizophr Bull
2013; 39: 1296–306.
Marshall, M, Lewis, S, Lockwood, A, Drake, R, Jones, P, Croudace, T. Association between duration of untreated psychosis and outcome in cohorts of first-episode patients: a systematic review. Arch Gen Psychiatry
2005; 62: 975–83.
Perkins, DO, Gu, H, Boteva, K, Lieberman, JA. Relationship between duration of untreated psychosis and outcome in first-episode schizophrenia: a critical review and meta-analysis. Am J Psychiatry
2005; 162: 1785–804.
Bertelsen, M, Jeppesen, P, Petersen, L, Thorup, A, Øhlenschlaeger, J, le Quach, P, et al. Five-year follow-up of a randomized multicenter trial of intensive early intervention vs standard treatment for patients with a first episode of psychotic illness: the OPUS trial. Arch Gen Psychiatry
2008; 65: 762–71.
Gafoor, R, Nitsch, D, McCrone, P, Craig, TKJ, Garety, PA, Power, P, et al. Effect of early intervention on 5-year outcome in non-affective psychosis. Br J Psychiatry
2010; 196: 372–6.
Hegelstad, WT, Larsen, TK, Auestad, B, Evensen, J, Haahr, U, Joa, I, et al. Long-term follow-up of the TIPS early detection in psychosis study: effects on 10-year outcome. Am J Psychiatry
2012; 169: 374–80.
Penttilä, M, Miettunen, J, Koponen, H, Kyllönen, M, Veijola, J, Isohanni, M, et al. Association between the duration of untreated psychosis and short- and long-term outcome in schizophrenia within the Northern Finland 1966 Birth Cohort. Schizophr Res
2013; 143: 3–10.
Norman, RMG, Townsend, L, Malla, AK. Duration of untreated psychosis and cognitive functioning in first-episode patients. Br J Psychiatry
2001; 179: 340–5.
Dassa, D, Boyer, L, Benoit, M, Bourcet, S, Raymondet, P, Bottai, T. Factors associated with medication non-adherence in patients suffering from schizophrenia: a cross-sectional study in a universal coverage health-care system. Aust N Z J Psychiatry
2010; 44: 921–8.
Stroup, DF, Berlin, JA, Morton, SC, Olkin, I, Williamson, GD, Rennie, D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA
2000; 283: 2008–12.
McGrath, J, Saha, S, Welham, J, El Saadi, O, MacCauley, C, Chant, D. A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology. BMC Med
2004; 28: 2–13.
Menezes, NM, Arenovich, T, Zipursky, RB. A systematic review of longitudinal outcome studies of first-episode psychosis. Psychol Med
2006; 36: 1349–62.
Shrivastava, A, Johnston, M, Shah, N, Bureau, Y. Redefining outcome measures in schizophrenia: integrating social and clinical parameters. Curr Opin Psychiatry
2010; 23: 120–6.
Parellada, M, Boada, L, Fraguas, D, Reig, S, Castro-Fornieles, J, Moreno, D, et al. Trait and state attributes of insight in first episodes of early-onset schizophrenia and other psychoses: a 2-year longitudinal study. Schizophr Bull
2011; 37: 38–51.
Nielssen, OB, Malhi, GS, McGorry, PD, Large, MM. Overview of violence to self and others during the first episode of psychosis. J Clin Psychiatry
2012; 73: e580–7.
Andreasen, NC, Carpenter, WT, Kane, JM, Lasser, RA, Marder, SR, Weinberger, DR. Remission in schizophrenia: proposed criteria and rationale for consensus. Am J Psychiatry
2005; 162: 441–9.
Faerden, A, Nesvåg, R, Marder, SR. Definitions of the term ‘recovered’ in schizophrenia and other disorders. Psychopathology
2008; 41: 271–8.
Rosenthal, R. Parametric measures of effect size. In The Handbook of Research Synthesis (eds Cooper, H, Hedges, LV). Sage, 1994.
Rosenthal, R, Rosnow, RL, Rubin, DB. Contrasts and Effect Sizes in Behavioral Research: A Correlational Approach: 212. Cambridge University Press, 2000.
Cohen, J. A power primer. Psychol Bull
1992; 112: 155–9.
Stata Corporation. Stata User's Guide, Release 11. Stata Press; 2009.
Higgins, JP, Thompson, SG, Deeks, JJ, Altman, DG. Measuring inconsistency in meta-analyses. BMJ
2003; 327: 557–60.
Sterne, J. Meta-Analysis in Stata: An Updated Collection from the Stata Journal.
Stata Press, 2009.
Röpcke, B, Eggers, C. Early-onset schizophrenia: a 15-year follow-up. Eur Child Adolesc Psychiatry
2005; 14: 341–50.
Górna, K, Jaracz, K, Rybakowski, F, Rybakowski, J. Determinants of objective and subjective quality of life in first-time-admission schizophrenic patients in Poland: a longitudinal study. Qual Life Res
2008; 17: 237–47.
White, C, Stirling, J, Hopkins, R, Morris, J, Montague, L, Tantam, D, et al. Predictors of 10-year outcome of first-episode psychosis. Psychol Med
2009; 39: 1447–56.
Hill, M, Crumlish, N, Clarke, M, Whitty, P, Owens, E, Renwick, L, et al. Prospective relationship of duration of untreated psychosis to psychopathology and functional outcome over 12 years. Schizophr Res
2012; 141: 215–21.
Boonstra, N, Klaassen, R, Sytema, S, Marshall, M, De Haan, L, Wunderink, L, et al. Duration of untreated psychosis and negative symptoms – a systematic review and meta-analysis of individual patient data. Schizophr Res
2012; 142: 12–9.
McGlashan, TH. Premorbid adjustment, onset types, and prognostic scaling: still informative?
2008; 34: 801–5.
Compton, MT, Chien, VH, Leiner, AS, Goulding, SM, Weiss, PS. Mode of onset of psychosis and family involvement in help-seeking as determinants of duration of untreated psychosis. Soc Psychiatry Psychiatr Epidemiol
2008; 43: 975–82.
Compton, MT, Gordon, TL, Weiss, PS, Walker, EF. The ‘doses’ of initial, untreated hallucinations and delusions: a proof-of-concept study of enhanced predictors of first-episode symptomatology and functioning relative to duration of untreated psychosis. J Clin Psychiatry
2011; 72: 1487–93.
Tandon, R. Antipsychotics in the treatment of schizophrenia: an overview. J Clin Psychiatry
2011; 72 (supp 1): 4–8.
Chiliza, B, Asmal, L, Emsley, R. Early intervention in schizophrenia in developing countries: focus on duration of untreated psychosis and remission as a treatment goal. Int Rev Psychiatry
2012; 24: 483–8.
Moncrieff, J. Questioning the ‘neuroprotective’ hypothesis: does drug treatment prevent brain damage in early psychosis or schizophrenia?
Br J Psychiatry
2011; 198: 85–7.
Ichinose, H, Nakane, Y, Nakane, H, Kinoshita, H, Ohta, Y, Honda, S. Nagasaki Schizophrenia Study: relationship between ultralong-term outcome (after 28 years) and duration of untreated psychosis. Acta Med Nagasaki
2010; 54: 59–66.
Bottlender, R, Sato, T, Jager, M, Wegener, U, Wittmann, J, Strauss, A, et al. The impact of the duration of untreated psychosis prior to first psychiatric admission on the 15-year outcome in schizophrenia. Schizophr Res
2003; 62: 37–44.
Chang, WC, Tang, JY, Hui, CL, Lam, MM, Wong, GH, Chan, SK, et al. Duration of untreated psychosis: relationship with baseline characteristics and three-year outcome in first-episode psychosis. Psychiatry Res
2012; 198: 360–5.
Norman, RM, Manchanda, R, Windell, D, Harricharan, R, Northcott, S, Hassall, L. The role of treatment delay in predicting 5-year outcomes in an early intervention program. Psychol Med
2012; 42: 223–33.
Selten, JP, Veen, ND, Hoek, HW, Laan, W, Schols, D, van der Tweel, I, et al. Early course of schizophrenia in a representative Dutch incidence cohort. Schizophr Res
2007; 97: 79–87.
Rupp, C, Fletcher, E. A five to ten year follow-up study of 641 schizophrenic cases. Am J Psychiatry
1940; 96: 877–88.
Achte, K. On prognosis and rehabilitation in schizophrenic and paranoid psychoses: a comparative follow-up study of two series of patients first admitted to hospital in 1950 and 1960 respectively. Acta Psychiatr Scand
1967; 43: 9–217.
Scully, PJ, Coakley, G, Kinsella, A, Waddington, JL. Psychopathology, executive (frontal) and general cognitive impairment in relation to duration of initially untreated versus subsequently treated psychosis in chronic schizophrenia. Psychol Med
1997; 27: 1303–10.
Jeppesen, P, Petersen, L, Thorup, A, Abel, MB, Øhlenschlaeger, J, Christensen, TØ, et al. The association between pre-morbid adjustment, duration of untreated psychosis and outcome in first-episode psychosis. Psychol Med
2008; 38: 1157–66.
Petersen, L, Thorup, A, Øqhlenschlaeger, J, Christensen, TØ, Jeppesen, P, Krarup, G, et al. Predictors of remission and recovery in a first-episode schizophrenia spectrum disorder sample: 2-year follow-up of the OPUS trial. Can J Psychiatry
2008; 53: 660–70.
Tomotake, M. Quality of life and its predictors in people with schizophrenia. J Med Invest
2011; 58: 167–74.
Thorup, A, Petersen, L, Jeppesen, P, Nordentoft, M. The quality of life among first-episode psychotic patients in the OPUS trial. Schizophr Res
2010; 116: 27–34.