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Effects of long-term treatment with antipsychotics on serum leptin levels

  • Andrés Herrán (a1), María Teresa García-Unzueta (a2), José Antonio Amado (a2), María Teresa De La Maza (a3), Concepción Álvarez (a3) and José Luis Vázquez-Barquero (a4)...
Abstract
Background

Abnormal regulation of the adipocyte-derived hormone leptin could play a role in body weight gain induced by antipsychotics.

Aims

To study the effects of long-term antipsychotic treatment on leptin levels in patients with schizophrenia.

Method

Serum leptin levels were determined in 59 out-patients with chronic schizophrenia and in the same number of healthy subjects controlled by gender, age and body mass index.

Results

Leptin levels did not differ between patients and controls. Leptin levels in patients with schizophrenia correlated with weight gain, even after controlling for current weight, but did not show any association with clinical variables. Antipsychotic class tended to exert different effects over leptin levels (among atypicals, olanzapine induced a greater increase).

Conclusions

Elevation of leptin levels induced by chronic antipsychotic treatment can be attributed to weight gain, but other mechanisms could be involved.

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Copyright
Corresponding author
Andrés Herrán, Clinical and Social Psychiatry Research Unit, Department of Psychiatry, University Hospital Marqués de Valdecilla, Avda. de Valdecilla s/n, 39008 Santander, Spain. Tel: 34 942 202545; Fax: 34 942 203447; e-mail: herran@humv.es
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Declaration of interest

This study was supported by a grant from the Fundación Marqués deValdecilla, 1996.

Footnotes
References
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Effects of long-term treatment with antipsychotics on serum leptin levels

  • Andrés Herrán (a1), María Teresa García-Unzueta (a2), José Antonio Amado (a2), María Teresa De La Maza (a3), Concepción Álvarez (a3) and José Luis Vázquez-Barquero (a4)...
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