Motor disorders occurring in association with phenothiazine therapy have been widely appreciated and investigated since the advent of these drugs in the early nineteen-fifties. Published works have indicated that between 20 and 40 per cent of patients treated with phenothiazines exhibit signs of extrapyramidal dysfunction (Denham, 1961; Ayd, 1961). However, the relationship between treatment variables and the frequency of these motor disorders is not a simple one. Many factors are likely to have aetiological significance, and it seems that their occurrence is more a reflection of personal idiosyncrasy than of chemical structure, dosage or duration of treatment (Lancet, 1964).
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