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Grey matter abnormalities in Brazilians with first-episode psychosis

  • Maristela S. Schaufelberger (a1), Fabio L. S. Duran (a2), Julia M. Lappin (a3), Marcia Scazufca (a4), Edson Amaro (a5), Claudia C. Leite (a6), Claudio C. De Castro (a7), Robin M. Murray (a7), Philip K. McGuire (a7), Paulo R. Menezes (a7) and Geraldo F. Busatto (a7)...
Abstract
Background

In low-and middle-income countries people with schizophrenia are reported to experience better outcomes than those in high-income countries

Aims

To examine structural brain differences in people with first-episode psychosis and controls in Brazil

Method

Magnetic resonance imaging using voxel-based morphometry was performed on 122 people with first-episode psychosis and 94 controls

Results

There were significant decreases in grey matter in the left superior temporal and inferior prefrontal cortices, insula bilaterally and the right hippocampal region in first-episode psychosis (P<0.05, corrected for multiple comparisons). The subgroup of people with schizophrenia (n=62) exhibited a similar pattern of decrease in grey matter relative to controls

Conclusions

Structural abnormalities reported in psychosis in high-income countries are also present in first-episode psychosis in Brazil

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Copyright
Corresponding author
Dr Geraldo F. Busatto, Departamento de Psiquiatria, Faculdade de Medicina — Universidade de São Paulo, Rua Ovídio Pires Campos, s/n – CEP 05403-903, São Paulo – SP Brazil. Email: geraldo.busatto@hcnet.usp.br
Footnotes
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*

Preliminary analyses of these data were presented in abstract form at the XII and XIII Biennial Winter Workshops on Schizophrenia Research, 2004 and 2006.

Declaration of interest

None.

Funding detailed in Acknowledgements.

Footnotes
References
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Grey matter abnormalities in Brazilians with first-episode psychosis

  • Maristela S. Schaufelberger (a1), Fabio L. S. Duran (a2), Julia M. Lappin (a3), Marcia Scazufca (a4), Edson Amaro (a5), Claudia C. Leite (a6), Claudio C. De Castro (a7), Robin M. Murray (a7), Philip K. McGuire (a7), Paulo R. Menezes (a7) and Geraldo F. Busatto (a7)...
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