Skip to main content
×
×
Home

Grey matter abnormalities in first-episode schizophrenia and affective psychosis

  • Kevin D. Morgan (a1), Paola Dazzan (a1), Kenneth G. Orr (a1), Gerard Hutchinson (a1), Xavier Chitnis (a1), John Suckling (a1), David Lythgoe (a1), Sarah-Jayne Pollock (a2), Susan Rossell (a3), Jane Shapleske (a4), Paul Fearon (a5), Craig Morgan (a6), Anthony David (a7), Philip K. Mcguire (a8), Peter B. Jones (a9), Julian Leff (a10) and Robin M. Murray (a9)...
Abstract
Background

Grey matter and other structural brain abnormalities are consistently reported in first-onset schizophrenia, but less is known about the extent of neuroanatomical changes in first-onset affective psychosis

Aims

To determine which brain abnormalities are specific to (a) schizophrenia and (b) affective psychosis

Method

We obtained dual-echo (proton density/T2-weighted) magnetic resonance images and carried out voxel-based analysis on the images of 73 patients with first-episode psychosis (schizophrenia n=44, affective psychosis n=29) and 58 healthy controls

Results

Both patients with schizophrenia and patients with affective psychosis had enlarged lateral and third ventricle volumes. Regional cortical grey matter reductions (including bilateral anterior cingulate gyrus, left insula and left fusiform gyrus) were evident in affective psychosis but not in schizophrenia, although patients with schizophrenia displayed decreased hippocampal grey matter and increased striatal grey matter at a more liberal statistical threshold

Conclusions

Both schizophrenia and affective psychosis are associated with volumetric abnormalities at the onset of frank psychosis, with some of these evident in common brain areas

  • View HTML
    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Grey matter abnormalities in first-episode schizophrenia and affective psychosis
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Grey matter abnormalities in first-episode schizophrenia and affective psychosis
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Grey matter abnormalities in first-episode schizophrenia and affective psychosis
      Available formats
      ×
Copyright
Corresponding author
Kevin Morgan, Department of Psychology, University of Westminster, 309 Regent Street, London WIB 2UW UK. Email: k.d.morgan@wmin.ac.uk
Footnotes
Hide All

Declaration of interest

None.

Funding detailed in Acknowledgements.

Footnotes
References
Hide All
Bebbington, P. & Nayani, T. (1995) The psychosis screening questionnaire. International Journal of Methods in Psychiatry Research, 5, 1119.
Bremner, J. D. Vythilingam, M. Vermetten, E. et al (2002) Reduced volume of orbitofrontal cortex in major depression. Biological Psychiatry, 51, 273279.
Bullmore, E. T. Suckling, J. Overmeyer, S. et al (1999) Global voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain. IEEE Transactions on Medical Imaging, 18, 3242.
Cahn, W. Pol, H. E. H. Lems, E. B. T. E. et al (2002) Brain volume changes in first-episode schizophrenia – A 1-year follow-up study. Archives of General Psychiatry, 59, 10021010.
Corson, P. W. O'Leary, D. S. Miller, D. D. et al (1999) Change in basal ganglia volume over 2 years in patients with schizophrenia: typical versus atypical neuroleptics. American Journal of Psychiatry, 56, 12001204.
Corson, P. W. O'Leary, D. S. Miller, D. D. et al (2002) The effects of neuroleptic medications on basal ganglia blood flow in schizophreniform disorders: A comparison between the neuroleptic-naive and medicated states. Biological Psychiatry, 52, 855862.
Dazzan, P. Morgan, K. D. Orr., K. G. et al (2004) The structural brain correlates of neurological soft signs in ÆESOP first-episode psychoses study. Brain, 127 (pt 1), 143153.
Dazzan, P. Morgan, K. Orr, K. G. et al (2005) Different effects of typical and atypical antipsychotics on grey matter in first episode psychosis: The ÆSOP study. Neuropsychopharmacology, 30, 765774.
Fannon, D. Chitnis, X. Doku, V. et al (2000a) Features of structural brain abnormality detected in first-episode psychosis. American Journal of Psychiatry, 157, 18291834.
Fannon, D. Tennakoon, L. O'Ceallaigh, S. et al (2000b) Third ventricle enlargement and developmental delay in first-episode psychosis: preliminary findings. British Journal of Psychiatry, 77, 354359.
Garver, D. L. Holcomb, J. A. & Christensen, J. D. (2005) Cerebral cortical gray expansion associated with two second-generation antipsychotics. Biological Psychiatry, 58, 6266.
Job, D. E. Whalley, H. C. McConnell, S. et al (2002) Structural gray matter differences between first-episode schizophrenics and normal controls using voxel-based morphometry. Neuroimage, 7, 880889.
Kasai, K. Shenton, M. E. Salisbury, D. F. et al (2003a) Progressive decrease of left superior temporal gyrus gray matter volume in patients with first-episode schizophrenia. American Journal of Psychiatry, 160, 156164.
Kasai, K. Shenton, M. E. Salisbury, D. F. et al (2003b) Differences and similarities in insular and temporal pole MRI gray matter volume abnormalities in first-episode schizophrenia and affective psychosis. Archives of General Psychiatry, 60, 10691077.
Kubicki, M. Shenton, M. E. Salisbury, D. F. et al (2002) Voxel-based morphornetric analysis of gray matter in first episode schizophrenia. Neuroimage, 17, 17111719.
Lawrie, S. M. & Abukmeil, S. S. (1998) Brain abnormality in schizophrenia. A systematic and quantitative review of volumetric magnetic resonance imaging studies. British Journal of Psychiatry, 72, 110120.
Lieberman, J. A. Tollefson, G. D. Charles, C. et al (2005) Antipsychotic drug effects on brain morphology in first onset psychosis. Archives of General Psychiatry, 62, 361370.
McDonald, C. Bullmore, E. T. Sham, P. C. et al (2004) Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Archives of General Psychiatry, 6, 974984.
Morgan, C. Dazzan, P. Morgan, K. et al (2006) First episode psychosis and ethnicity: initial findings from the ÆSOP study. World Psychiatry, 5, 4046.
Nelson, H. & Willison, R. (1991) National Adult Reading Test (part II) Test Manual. nfer-Nelson.
Onitsuka, T. Shenton, M. E. Kasai, K. et al (2003) Fusiform gyrus volume reduction and facial recognition in chronic schizophrenia. Archives of General Psychiatry, 60, 349355.
Pantelis, C. Velakoulis, D. McGorry, P. D. et al (2003) Neuroanatomical abnormalities before and after onset of psychosis: a cross-sectional and longitudinal MRI comparison. Lancet, 36, 281288.
Sassi, R. B. Brambilla, P. Hatch, J. P. et al (2004) Reduced left anterior cingulate volumesin untreated bipolar patients. Biological Psychiatry, 56, 467475.
Sigmundsson, T. Suckling, J. Maier, M. et al (2001) Structural abnormalities in frontal, temporal, and limbic regions and interconnecting white matter tracts in schizophrenic patients with prominent negative symptoms. American Journal of Psychiatry, 58, 234243.
Suckling, J. Sigmundsson, T. Greenwood, K. et al (1996) A modified fuzzy clustering algorithm for operator independent brain tissue classification of dual echo MR images. Magnetic Resonance Imaging, 17, 10651076.
Wing, J. K. & Sturt, E. (1978) The PSE-ID-CATEGO System: Supplementary Manual. Medical Research Council.
World Health Organization (1992) ICD-10 Classification of Mental and Behavioural Disorders. WHO.
World Health Organization (1994) Schedules for Clinical Assessment in Neuropsychiatry (SCAN 2.0). WHO.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×
Type Description Title
UNKNOWN
Supplementary materials

Morgan et al. supplementary material
Supplementary Material

 Unknown (482 bytes)
482 bytes
PDF
Supplementary materials

Morgan et al. supplementary material
Supplementary Figure S1

 PDF (676 KB)
676 KB

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed

Grey matter abnormalities in first-episode schizophrenia and affective psychosis

  • Kevin D. Morgan (a1), Paola Dazzan (a1), Kenneth G. Orr (a1), Gerard Hutchinson (a1), Xavier Chitnis (a1), John Suckling (a1), David Lythgoe (a1), Sarah-Jayne Pollock (a2), Susan Rossell (a3), Jane Shapleske (a4), Paul Fearon (a5), Craig Morgan (a6), Anthony David (a7), Philip K. Mcguire (a8), Peter B. Jones (a9), Julian Leff (a10) and Robin M. Murray (a9)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *