Skip to main content
×
×
Home

Long-term outcome of two forms of randomised benzodiazepine discontinuation

  • R. C. Oude Voshaar (a1), W. J. M. J. Gorgels (a2), A. J. J. Mol (a1), A. J. L. M. Van Balkom (a3), J. Mulder (a2), E. H. Van De Lisdonk (a2), M. H. M. Breteler (a4) and F. G. Zitman (a5)...
Summary

Abouttwo-thirds of long-term users of benzodiazepines in the population are able to discontinue this drug with the aid of supervised programmes for tapering off. Little is known about the long-term outcome of such programmes, and they have never been compared with usual care. After a 15-month follow-up of a randomised controlled trial comparing such a programme with and without psychotherapy with usual care, we found significantly higher longitudinal abstinence rates in long-term benzodiazepine users who received a benzodiazepine tapering-off programme without psychotherapy (25 out of 69, 36%) compared with those who received usual care (5 out of 33, 15%; P=0.03).

    • Send article to Kindle

      To send this article to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about sending to your Kindle. Find out more about sending to your Kindle.

      Note you can select to send to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be sent to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

      Find out more about the Kindle Personal Document Service.

      Long-term outcome of two forms of randomised benzodiazepine discontinuation
      Available formats
      ×
      Send article to Dropbox

      To send this article to your Dropbox account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Dropbox.

      Long-term outcome of two forms of randomised benzodiazepine discontinuation
      Available formats
      ×
      Send article to Google Drive

      To send this article to your Google Drive account, please select one or more formats and confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your <service> account. Find out more about sending content to Google Drive.

      Long-term outcome of two forms of randomised benzodiazepine discontinuation
      Available formats
      ×
Copyright
Corresponding author
Dr R.C. Oude Voshaar, Department of Psychiatry Radboud University Medical Centre Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands. E-mail: r.oudevoshaar@psy.umcn.nl
Footnotes
Hide All

Declaration of Interest

None.

Footnotes
References
Hide All
Ashton, H. (1987) Benzodiazepine withdrawal: outcome in 50 patients. British Journal of Addiction, 82, 665671.
Baillargeon, L., Landreville, P., Verreault, R., et al (2003) Discontinuation of benzodiazepines among older insomniac adults treated with cognitive–behavioural therapy combined with gradual tapering: a randomized trial. Journal of the Canadian Medical Association, 11, 10151020.
Couvee, J. E., Timmermans, E. A. & Zitman, F. G. (2002) The long-term outcome of a benzodiazepine discontinuation program in depressed outpatients. Journal of Affective Disorders, 70, 133141.
Golombok, S., Higgitt, A., Fonagy, P., et al (1987) A follow-up study of patients treated for benzodiazepine dependence. British Journal of Medical Psychology, 60, 141149.
Holton, A., Riley, P. & Tyrer, P. (1992) Factors predicting long-term outcome alter chronic benzodiazepine therapy. Journal of Affective Disorders, 24, 245252.
Lader, M. (1994) Anxiety or depression during withdrawal of hypnotic treatments. Journal of Psychosomatic Research, 38, 113123.
Morin, C. M., Bastien, C., Guay, B., et al (2004) Randomized controlledtrial of supervised tapering and cognitive—behavior therapy to facilitate benzodiazepine discontinuation in older adults with chronic insomnia. American Journal of Psychiatry, 161, 332342.
Otto, M. W., Pollack, M. H., Sachs, G. S., et al (1993) Discontinuation of benzodiazepine treatment: efficacy of cognitive–behavioral therapy for patients with panic disorder. American Journal of Psychiatry, 150, 14851490.
Oude Voshaar, R. C., Gorgels, W. J. M. J., Mol, A. J. J., et al (2003) Tapering off long-term benzodiazepine use with or without group cognitive–behavioural therapy: three-condition randomised controlled trial. British Journal of Psychiatry, 182, 498504.
Oude Voshaar, R. C., Couvée, J. E., Van Balkom, A. J. L. M., et al (2006) Strategies to discontinue long-term benzodiazepine use: a meta-analysis. British Journal of Psychiatry in press.
Rickels, K., Case, W. G., Schweizer, E., et al (1991) Long-term benzodiazepine users 3 years after participation in a discontinuation program. American Journal of Psychiatry, 148, 757761.
Vorma, H., Naukkarinen, H., Sarna, S., et al (2002) Treatment of out-patients with complicated benzodiazepine dependence: comparison of two approaches. Addiction, 97, 851859.
World Health Organization Collaborating Centre for Drugs Statistics Methodology (1996) Guidelines ATC Classification and DDD Assignment (1st edn). Oslo: WHO/Norwegian Institute of Public Health.
Recommend this journal

Email your librarian or administrator to recommend adding this journal to your organisation's collection.

The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
Please enter your name
Please enter a valid email address
Who would you like to send this to? *
×
Type Description Title
UNKNOWN
Supplementary materials

Voshaar et al. supplementary material
Supplementary Material

 Unknown (581 bytes)
581 bytes
PDF
Supplementary materials

Voshaar et al. supplementary material
Supplementary Table S1

 PDF (26 KB)
26 KB

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 20 *
Loading metrics...

Abstract views

Total abstract views: 59 *
Loading metrics...

* Views captured on Cambridge Core between 3rd January 2018 - 26th May 2018. This data will be updated every 24 hours.

Long-term outcome of two forms of randomised benzodiazepine discontinuation

  • R. C. Oude Voshaar (a1), W. J. M. J. Gorgels (a2), A. J. J. Mol (a1), A. J. L. M. Van Balkom (a3), J. Mulder (a2), E. H. Van De Lisdonk (a2), M. H. M. Breteler (a4) and F. G. Zitman (a5)...
Submit a response

eLetters

No eLetters have been published for this article.

×

Reply to: Submit a response


Your details


Conflicting interests

Do you have any conflicting interests? *