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Prevention of bipolar episodes with lithium in the perinatal period

  • Angelika Wieck (a1)
Summary

Because lithium is now recommended as the initial long-term treatment for bipolar disorder in general and has a lower teratogenic potential than originally reported, it may become more frequently prescribed in childbearing women. The article by Wesseloo et al in this issue provides helpful data and guidance for managing lithium dosing in the perinatal period.

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References
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1 Jones, I, Chandra, PS, Dazzan, P, Howard, LM. Bipolar disorder, affective psychosis, and schizophrenia in pregnancy and the post-partum period. Lancet 2014; 384: 1789–99.
2 Wesseloo, R, Kamperman, AM, Munk-Olsen, T, Pop, VJ, Kushner, SA, Bergink, V. Risk of postpartum relapse in bipolar disorder and postpartum psychosis: a systematic review and meta-analysis. Am J Psychiatry 2016; 173: 117–27.
3 Viguera, AC, Nonacs, R, Cohen, LS, Tondo, L, Murray, A, Baldessarini, RJ. Risk of recurrence of bipolar disorder in pregnant and non-pregnant women after discontinuing lithium maintenance. Am J Psychiatry 2000; 157: 179–84.
4 Di Florio, A, Forty, L, Gordon-Smith, K, Heron, J, Jones, L, Craddock, N, et al. Perinatal episodes across the mood disorder spectrum, JAMA Psychiatry 2013; 70: 168–75.
5 Viguera, AC, Tondo, L, Koukopoulos, AE, Reginaldi, D, Lepri, B, Baldessarini, RJ. Episodes of mood disorders in 2,252 pregnancies and postpartum periods. Am J Psychiatry 2011; 168: 1179–85.
6 National Institute for Health and Care Excellence. Antenatal and Postnatal Mental Health: Clinical Management and Service Guidance. Clinical Guideline (CG) 192. NICE, 2014.
7 Goodwin, GM, Haddad, PM, Ferrier, IN, Aronson, JK, Barnes, T, Cipriani, A, et al. Evidence-based guidelines for treating bipolar disorder: revised third edition recommendations from the British Association for Psychopharmacology. J Psychopharmacol 2016; 30: 495553.
8 National Institute for Health and Care Excellence. Bipolar Disorder: Assessment and Management. Clinical Guidelines (CG) 185. NICE, 2014.
9 McCrea, RL, Nazareth, I, Evans, SJ, Osborn, DP, Pinfold, V, Cowen, PJ, et al. Lithium prescribing during pregnancy: a UK primary care database study. PLoS One 2015; 10: e0121024.
10 McKnight, RF, Adida, M, Budge, K, Stockton, S, Goodwin, GM, Geddes, JR. Lithium toxicity profile: a systematic review and meta-analysis. Lancet 2012; 379: 721–8.
11 Boyle, B, Garne, E, Loane, M, Addor, MC, Arriola, L, Cavero-Carbonell, C, et al. The changing epidemiology of Ebstein's anomaly and its relationship with maternal mental health conditions: a European registry-based study. Cardiol Young 2016; 30: 19.
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The British Journal of Psychiatry
  • ISSN: 0007-1250
  • EISSN: 1472-1465
  • URL: /core/journals/the-british-journal-of-psychiatry
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Prevention of bipolar episodes with lithium in the perinatal period

  • Angelika Wieck (a1)
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