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Quetiapine v. lithium in the maintenance phase following a first episode of mania: Randomised controlled trial

  • Michael Berk (a1), Rothanthi Daglas (a2), Orwa Dandash (a3), Murat Yücel (a3), Lisa Henry (a2), Karen Hallam (a4), Craig Macneil (a2), Melissa Hasty (a2), Christos Pantelis (a5), Brendan P. Murphy (a6), Linda Kader (a2), Saji Damodaran (a6), Michael T. H. Wong (a6), Philippe Conus (a7), Aswin Ratheesh (a2), Patrick D. McGorry (a2) and Sue M. Cotton (a2)...
Abstract
Background

Lithium and quetiapine are considered standard maintenance agents for bipolar disorder yet it is unclear how their efficacy compares with each other.

Aims

To investigate the differential effect of lithium and quetiapine on symptoms of depression, mania, general functioning, global illness severity and quality of life in patients with recently stabilised first-episode mania.

Method

Maintenance trial of patients with first-episode mania stabilised on a combination of lithium and quetiapine, subsequently randomised to lithium or quetiapine monotherapy (up to 800 mg/day) and followed up for 1 year. (Trial registration: Australian and New Zealand Clinical Trials Registry – ACTRN12607000639426.)

Results

In total, 61 individuals were randomised. Within mixed-model repeated measures analyses, significant omnibus treatment × visit interactions were observed for measures of overall psychopathology, psychotic symptoms and functioning. Planned and post hoc comparisons further demonstrated the superiority of lithium treatment over quetiapine.

Conclusions

In people with first-episode mania treated with a combination of lithium and quetiapine, continuation treatment with lithium rather than quetiapine is superior in terms of mean levels of symptoms during a 1-year evolution.

Copyright
Corresponding author
Michael Berk, Deakin University, IMPACT Strategic Research Centre, School of Medicine, 75 Pigdon's Road, Waurn Ponds, Geelong, Victoria, 3216, Australia. Email: mikebe@barwonhealth.org.au
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Declaration of interest

This study was supported by an unrestricted grant from AstraZeneca. R.D., M.H. and K.H. worked on a study that has received research support by AstraZeneca. M.B. has received grant/research support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of Victoria, Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Rotary Health, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Meat and Livestock Board, Organon, Novartis, Mayne Pharma, Servier and Woolworths, has been a speaker for AstraZeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen-Cilag, Lundbeck, Merck, Pfizer, Sanofi Synthelabo, Servier, Solvay and Wyeth, and served as a consultant to AstraZeneca, Bioadvantex, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen-Cilag, Lundbeck Merck and Servier. C.M. has received a grant/research support from Eli Lilly and AstraZeneca, Janssen Cilag and Sanofi Aventis, and served as a consultant to AstraZeneca and Eli Lilly. P.D.M. has received investigator initiated research grants from AstraZeneca, Janssen-Cilag, Eli Lilly and BMS. He has received honoraria for educational events from Janssen-Cilag, Eli Lilly, BMS, AstraZeneca, Pfizer and Lundbeck. C.P. has participated on Advisory Boards for Janssen-Cilag, AstraZeneca, Lundbeck and Servier, has received honoraria for talks presented at educational meetings organised by AstraZeneca, Janssen-Cilag, Eli-Lilly, Pfizer, Lundbeck and Shire.

Footnotes
References
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Quetiapine v. lithium in the maintenance phase following a first episode of mania: Randomised controlled trial

  • Michael Berk (a1), Rothanthi Daglas (a2), Orwa Dandash (a3), Murat Yücel (a3), Lisa Henry (a2), Karen Hallam (a4), Craig Macneil (a2), Melissa Hasty (a2), Christos Pantelis (a5), Brendan P. Murphy (a6), Linda Kader (a2), Saji Damodaran (a6), Michael T. H. Wong (a6), Philippe Conus (a7), Aswin Ratheesh (a2), Patrick D. McGorry (a2) and Sue M. Cotton (a2)...
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