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Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study

  • Sean J. Colloby (a1), Michael J. Firbank (a1), Jiabao He (a1), Alan J. Thomas (a1), Akshya Vasudev (a1), Steve W. Parry (a1) and John T. O'Brien (a1)...

Abstract

Background

A limited number of studies have demonstrated changes in cerebral blood flow (CBF) in older individuals with depression, but there are considerable inconsistencies between studies.

Aims

To investigate changes in CBF using arterial spin labelling (ASL) magnetic resonance imaging (MRI) in people with late-life depression and in a similarly aged healthy control group.

Method

Sixty-eight participants (30 healthy individuals, 38 with depression) underwent ASL and T 1-weighted MRI scanning. For each individual, regional estimates of separate grey and white matter CBF were obtained. Group differences in CBF and their associations with clinical features were examined.

Results

Significant increases were observed in white matter CBF in patients with depression relative to the control group (F 1,65 = 9.7, P = 0.003). Grey matter CBF in lateral frontal, medial frontal, cingulate, central and parietal regions did not significantly differ between groups (F 1,65≤2.1, P≥0.2). A significant correlation was found between white matter CBF and Montgomery–Åsberg Depression Rating Scale (MADRS) scores in depression (r’ =–0.42, P = 0.03). Further analyses revealed that compared with controls, significant elevation of white matter CBF was apparent in participants whose depression was in remission (n = 21, MADRS≤10, P = 0.001) but not in those with current depression (n = 17, MADRS≥11, P = 0.80).

Conclusions

Findings suggest a compensatory response to white matter pathological change or a response to (or a predictor of) successful antidepressant treatment, perhaps by facilitating neurotransmission in specific circuits and so reducing depressive symptoms.

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Copyright

Corresponding author

Dr Sean J. Colloby, Institute for Ageing and Health, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK. Email: s.j.colloby@ncl.ac.uk

Footnotes

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Declaration of interest

None.

Footnotes

References

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Regional cerebral blood flow in late-life depression: arterial spin labelling magnetic resonance study

  • Sean J. Colloby (a1), Michael J. Firbank (a1), Jiabao He (a1), Alan J. Thomas (a1), Akshya Vasudev (a1), Steve W. Parry (a1) and John T. O'Brien (a1)...
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