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Two-week delay in onset of action of antidepressants: new evidence

Published online by Cambridge University Press:  02 January 2018

Alex J. Mitchell*
Department of Liaison Psychiatry, Leicester General Hospital, Leicester, UK
Dr Alex J. Mitchell, Department of Liaison Psychiatry, Brandon Unit, Leicester General Hospital, Leicester LE5 4PW, UK. E-mail:
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Many sources purport that antidepressants have a delayed onset of action, measured in weeks rather than days. Recent data using weekly or daily mood ratings demonstrate that maximum improvement occurs during the first 2 weeks, with some improvement within the first 3 days. Methodological issues may underlie the delayed-onset hypothesis.

Copyright © 2006 The Royal College of Psychiatrists 


Declaration of Interest



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