Skip to main content Accessibility help
×
Home

Children of the Twins Early Development Study (CoTEDS): A Children-of-Twins Study

  • Yasmin I. Ahmadzadeh (a1), Thalia C. Eley (a1), Robert Plomin (a1), Philip S. Dale (a2), Kathryn J. Lester (a3), Bonamy R. Oliver (a4), Andrew McMillan (a1) and Tom A. McAdams (a1)...

Abstract

The Children of the Twins Early Development Study (CoTEDS) is a new prospective children-of-twins study in the UK, designed to investigate intergenerational associations across child developmental stages. CoTEDS will enable research on genetic and environmental factors that underpin parent–child associations, with a focus on mental health and cognitive-related traits. Through CoTEDS, we will have a new lens to examine the roles that parents play in influencing child development, as well as the genetic and environmental factors that shape parenting behavior and experiences. Recruitment is ongoing from the sample of approximately 20,000 contactable adult twins who have been enrolled in the Twins Early Development Study (TEDS) since infancy. TEDS twins are invited to register all offspring to CoTEDS at birth, with 554 children registered as of May 2019. By recruiting the second generation of TEDS participants, CoTEDS will include information on adult twins and their offspring from infancy. Parent questionnaire-based data collection is now underway for 1- and 2-year-old CoTEDS infants, with further waves of data collection planned. Current data collection includes the following primary constructs: child mental health, temperament, language and cognitive development; parent mental health and social relationships; parenting behaviors and feelings; and other socioecological factors. Measurement tools have been selected with reference to existing genetically informative cohort studies to ensure overlap in phenotypes measured at corresponding stages of development. This built-in study overlap is intended to enable replication and triangulation of future analyses across samples and research designs. Here, we summarize study protocols and measurement procedures and describe future plans.

Copyright

Corresponding author

Author for correspondence: Tom A. McAdams, Email: tom.mcadams@kcl.ac.uk

References

Hide All
Ahmadzadeh, Y. I., Eley, T. C., Leve, L. D., Shaw, D. S., Natsuaki, M. N., Reiss, D., … McAdams, T. A. (2019). Anxiety in the family: A genetically informed analysis of transactional associations between mother, father and child anxiety symptoms. Journal of Child Psychology and Psychiatry. Advance online publication. doi:10.1111/jcpp.13068
Angold, A., Costello, E. J., Messer, S. C., & Pickles, A. (1995). Development of a short questionnaire for use in epidemiological studies of depression in children and adolescents [Press release].
Arnold, D. S., O’Leary, S. G., Wolff, L. S., & Acker, M. M. (1993). The Parenting Scale: A measure of dysfunctional parenting in discipline situations. Psychological Assessment, 5, 137144.
Avinun, R., & Knafo, A. (2014). Parenting as a reaction evoked by children’s genotype: A meta-analysis of children-as-twins studies. Personality and Social Psychology Review, 18, 87102.
Bates, J. E., Freeland, C. A., & Lounsbury, M. L. (1979). Measurement of infant difficultness. Child Development, 50, 794803.
Boivin, M., Perusse, D., Dionne, G., Saysset, V., Zoccolillo, M., Tarabulsy, G. M., … Tremblay, R. E. (2005). The genetic-environmental etiology of parents’ perceptions and self-assessed behaviours toward their 5-month-old infants in a large twin and singleton sample. Journal of Child Psychology and Psychiatry, 46, 612630.
Bouchard, T. J., & McGue, M. (1981). Familial studies of intelligence – A review. Science, 212, 10551059.
Boutwell, B. B., & Beaver, K. M. (2010). The intergenerational transmission of low self-control. Journal of Research in Crime and Delinquency, 47, 174209.
Boyd, A., Golding, J., Macleod, J., Lawlor, D. A., Fraser, A., Henderson, J., … Smith, G. D. (2013). Cohort Profile: The ‘Children of the 90s’ – The index offspring of the Avon Longitudinal Study of Parents and Children. International Journal of Epidemiology, 42, 111127.
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989). The Pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Research, 28, 193213.
Carter, A. S., Briggs-Gowan, M. J., Jones, S. M., & Little, T. D. (2003). The Infant-Toddler Social and Emotional Assessment (ITSEA): Factor structure, reliability, and validity. Journal of Abnormal Child Psychology, 31, 495514.
Chassin, L., Presson, C., Seo, D. C., Sherman, S. J., Macy, J., Wirth, R. J., & Curran, P. (2008). Multiple trajectories of cigarette smoking and the intergenerational transmission of smoking: A multigenerational, longitudinal study of a midwestern community sample. Health Psychology, 27, 819828.
Chorpita, B. F., Yim, L., Moffitt, C., Umemoto, L. A., & Francis, S. E. (2000). Assessment of symptoms of DSM-IV anxiety and depression in children: A revised child anxiety and depression scale. Behaviour Research and Therapy, 38, 835855.
Conger, R. D., Conger, K. J., Elder, G. H., Lorenz, F. O., Simons, R. L., & Whitbeck, L. B. (1992). A family process model of economic hardship and adjustment of early adolescent boys. Child Development, 63, 526541.
Conger, R. D., Lasley, P., Lorenz, F. O., Simons, R., Whitbeck, L. B., Elder, G. H. Jr., & Norem, R. (2011). Iowa youth and families project, 1989–1992. Ann Arbor, MI: Inter-university Consortium for Political and Social Research, 2011-11-03. doi: 10.3886/ICPSR26721.v2
Cox, J. L., Holden, J. M., & Sagovsky, R. (1987). Detection of postnatal depression. Development of the 10-item Edinburgh Postnatal Depression Scale. British Journal of Psychiatry, 150, 782786.
Crnic, K. A., & Greenberg, M. T. (1990). Minor parenting stresses with young children. Child Development, 61, 16281637.
Cui, M., Lorenz, F. O., Conger, R. D., Melby, J. N., & Bryant, C. M. (2005). Observer, self-, and partner reports of hostile behaviors in romantic relationships. Journal of Marriage and Family, 67, 11691181.
Dale, P. S., Dionne, G., Eley, T. C., & Plomin, R. (2000). Lexical and grammatical development: A behavioural genetic perspective. Journal of Child Language, 27, 619642.
Dale, P. S., Simonoff, E., Bishop, D. V., Eley, T. C., Oliver, B., Price, T. S., … Plomin, R. (1998). Genetic influence on language delay in two-year-old children. Nature Neuroscience, 1, 324328.
Davis, K. A. S., Coleman, J. R. I., Adams, M., Allen, N., Breen, G., Cullen, B., … Hotopf, M. (2018). Mental health in UK Biobank: Development, implementation and results from an online questionnaire completed by 157 366 participants. BJPsych Open, 4, 8390.
Deater-Deckard, K. (2000). Parenting and child behavioral adjustment in early childhood: A quantitative genetic approach to studying family processes. Child Development, 71, 468484.
D’Onofrio, B. M., Turkheimer, E. N., Eaves, L. J., Corey, L. A., Berg, K., Solaas, M. H., & Emery, R. E. (2003). The role of the children of twins design in elucidating causal relations between parent characteristics and child outcomes. Journal of Child Psychology and Psychiatry, 44, 11301144.
Elias, P., & Birch, M. (2010). SOC2010: The revision of the Standard Occupational Classification 2000. Coventry, UK: Institute for Employment Research, University of Warwick.
Fenson, L., Dale, P. S., Reznick, J. S., Bates, E., Thal, D. J., & Pethick, S. J. (1994). Variability in early communicative development. Monographs of the Society for Research in Child Development, 59, 1173; discussion 174–185.
Fischer, M. (2018). Psychoses in the offspring of schizophrenic monozygotic twins and their normal co-twins. British Journal of Psychiatry, 118, 4352.
Frankenburg, W. K., & Dodds, J. B. (1967). The Denver developmental screening test. The Journal of Pediatrics, 71, 181191.
Ginsburg, G. S., Grover, R. L., Cord, J. J., & Ialongo, N. (2006). Observational measures of parenting in anxious and nonanxious mothers: Does type of task matter? Journal of Clinical Child & Adolescent Psychology, 35, 323328.
Goldsmith, H. H. (1991). A zygosity questionnaire for young twins: A research note. Behavior Genetics, 21, 257269.
Goodman, R. (2001). Psychometric properties of the strengths and difficulties questionnaire. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 13371345.
Gregory, A. M., Buysse, D. J., Willis, T. A., Rijsdijk, F. V., Maughan, B., Rowe, R., … Eley, T. C. (2011). Associations between sleep quality and anxiety and depression symptoms in a sample of young adult twins and siblings. Journal of Psychosomatic Research, 71, 250255.
Haworth, C. M. A., Davis, O. S. P., & Plomin, R. (2013). Twins Early Development Study (TEDS): a genetically sensitive investigation of cognitive and behavioral development from childhood to young adulthood. Twin Research and Human Genetics, 16, 117125.
Heath, A. C., Kendler, K. S., Eaves, L. J., & Markell, D. (1985). The resolution of cultural and biological inheritance: Informativeness of different relationships. Behavior Genetics, 15, 439465.
Hertz, T., Jayasundera, T., Piraino, P., Selcuk, S., Smith, N., & Verashchagina, A. (2007). The inheritance of educational inequality: International comparisons and fifty-year trends. Advances in Economic Analysis & Policy, 7, 17751775.
Jaaskelainen, A., Pussinen, J., Nuutinen, O., Schwab, U., Pirkola, J., Kolehmainen, M., … Laitinen, J. (2011). Intergenerational transmission of overweight among Finnish adolescents and their parents: A 16-year follow-up study. International Journal of Obesity, 35, 12891294.
Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C., & Eaves, L. J. (1993). The lifetime history of major depression in women: Reliability of diagnosis and heritability. Archives of General Psychiatry, 50, 863870.
Koukounari, A., Pickles, A., Hill, J., & Sharp, H. (2015). Psychometric properties of the Parent-Infant Caregiving Touch Scale. Frontiers in Psychology, 6, 18871887.
Leve, L. D., Neiderhiser, J. M., Shaw, D. S., Ganiban, J., Natsuaki, M. N., & Reiss, D. (2013). The early growth and development study: A prospective adoption study from birth through middle childhood. Twin Research and Human Genetics, 16, 412423.
Magnus, P., Birke, C., Vejrup, K., Haugan, A., Alsaker, E., Daltveit, A. K., … Stoltenberg, C. (2016). Cohort profile update: The Norwegian Mother and Child Cohort Study (MoBa). International Journal of Epidemiology, 45, 382388.
Majdandžić, M., de Vente, W., & Bögels, S. M. (2016). Challenging parenting behavior from infancy to toddlerhood: Etiology, measurement, and differences between fathers and mothers. Infancy, 21, 423452.
Matheny, A. P., Wachs, T. D., Ludwig, J. L., & Phillips, K. (1995). Bringing order out of chaos: Psychometric characteristics of the confusion, hubbub, and order scale. Journal of Applied Developmental Psychology, 16, 429444.
Mathiesen, K. S., & Tambs, K. (1999). The EAS temperament questionnaire–factor structure, age trends, reliability, and stability in a Norwegian sample. Journal of Child Psychology and Psychiatry, 40, 431439.
McAdams, T. A., Hannigan, L. J., Eilertsen, E. M., Gjerde, L. C., Ystrom, E., & Rijsdijk, F. V. (2018). Revisiting the children-of-twins design: Improving existing models for the exploration of intergenerational associations. Behavior Genetics, 48, 397412.
McAdams, T. A., Neiderhiser, J. M., Rijsdijk, F. V., Narusyte, J., Lichtenstein, P., & Eley, T. C. (2014). Accounting for genetic and environmental confounds in associations between parent and child characteristics: A systematic review of children-of-twins studies. Psychological Bulletin, 140, 11381173.
McAdams, T. A., Rijsdijk, F. V., Narusyte, J., Ganiban, J. M., Reiss, D., Spotts, E., … Eley, T. C. (2017). Associations between the parent-child relationship and adolescent self-worth: A genetically informed study of twin parents and their adolescent children. Journal of Child Psychology and Psychiatry, 58, 4654.
Melby, J. N., Conger, R. D., Ge, X., & Warner, T. D. (1995). The use of structural equation modeling in assessing the quality of marital observations. Journal of Family Psychology, 9, 280293.
Micco, J. A., Henin, A., Mick, E., Kim, S., Hopkins, C. A., Biederman, J., & Hirshfeld-Becker, D. R. (2009). Anxiety and depressive disorders in offspring at high risk for anxiety: A meta-analysis. Journal of Anxiety Disorders, 23, 11581164.
Nance, W. E., & Corey, L. A. (1976). Genetic models for the analysis of data from the families of identical twins. Genetics, 83, 811826.
Oliver, B. R., & Pike, A. (2019). Maternal parenting observed using a novel online observation tool predicts maternal reports of children’s disruptive behaviour. Manuscript submitted for publication.
Oliver, B. R., & Plomin, R. (2007). Twins’ Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behavior problems from childhood through adolescence. Twin Research and Human Genetics, 10, 96105.
Oliver, B. R., Trzaskowski, M., & Plomin, R. (2014). Genetics of parenting: The power of the dark side. Developmental Psychology, 50, 12331240.
Plomin, R., DeFries, J. C., & Loehlin, J. C. (1977). Genotype-environment interaction and correlation in the analysis of human behavior. Psychological Bulletin, 84, 309322.
Polderman, T. J., Benyamin, B., de Leeuw, C. A., Sullivan, P. F., van Bochoven, A., Visscher, P. M., & Posthuma, D. (2015). Meta-analysis of the heritability of human traits based on fifty years of twin studies. Nature Genetics, 47, 702709.
Price, T. S., Freeman, B., Craig, I., Petrill, S. A., Ebersole, L., & Plomin, R. (2000). Infant zygosity can be assigned by parental report questionnaire data. Twin Research, 3, 129133.
Rimfeld, K., Malanchini, M., Spargo, T., Spickernell, G., Selzam, S., McMillan, A., … Plomin, R. (2019). Twins Early Development Study: A genetically sensitive investigation into behavioural and cognitive development from infancy to emerging adulthood. PsyArXiv. doi:10.31234/osf.io/xqh52
Rowe, D. C., & Plomin, R. (1977). Temperament in early childhood. Journal of Personality Assessment, 41, 150156.
Rutter, M., Pickles, A., Murray, R., & Eaves, L. (2001). Testing hypotheses on specific environmental causal effects on behavior. Psychological Bulletin, 127, 291324.
Sadeh, A. (2004). A brief screening questionnaire for infant sleep problems: Validation and findings for an Internet sample. Pediatrics, 113, e570577.
Sadeh, A., Mindell, J. A., Luedtke, K., & Wiegand, B. (2009). Sleep and sleep ecology in the first 3 years: A web-based study. Journal of Sleep Research, 18, 6073.
Saudino, K. J., Dale, P. S., Oliver, B., Petrill, S. A., Richardson, V., Rutter, M., … Plomin, R. (1998). The validity of parent-based assessment of the cognitive abilities of 2-year-olds. British Journal of Developmental Psychology, 16, 349363.
Saunders, J. B., Aasland, O. G., Babor, T. F., de la Fuente, J. R., & Grant, M. (1993). Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption–II. Addiction, 88, 791804.
Silberg, J. L., Maes, H., & Eaves, L. J. (2010). Genetic and environmental influences on the transmission of parental depression to children’s depression and conduct disturbance: An extended Children of Twins study. Journal of Child Psychology and Psychiatry, 51, 734744.
Skevington, S. M., Lotfy, M., & O’Connell, K. A. (2004). The World Health Organization’s WHOQOL-BREF quality of life assessment: Psychometric properties and results of the international field trial. A report from the WHOQOL group. Quality of Life Research, 13, 299310.
Spitzer, R. L., Kroenke, K., Williams, J. B. W., & Löwe, B. (2006). A brief measure for assessing generalized anxiety disorder: The GAD-7. Archives of Internal Medicine, 166, 10921097.
Stringaris, A., Goodman, R., Ferdinando, S., Razdan, V., Muhrer, E., Leibenluft, E., & Brotman, M. A. (2012). The affective reactivity index: A concise irritability scale for clinical and research settings. Journal of Child Psychology and Psychiatry, 53, 11091117.
Trouton, A., Spinath, F. M., & Plomin, R. (2002). Twins Early Development Study (TEDS): A multivariate, longitudinal genetic investigation of language, cognition and behavior problems in childhood. Twin Research and Human Genetics, 5, 444448.
Vidal, S. I., Vandeleur, C., Rothen, S., Gholam-Rezaee, M., Castelao, E., Halfon, O., … Preisig, M. (2012). Risk of mental disorders in children of parents with alcohol or heroin dependence: A controlled high-risk study. European Addiction Research, 18, 253264.
Winstanley, A., & Gattis, M. (2013). The baby care questionnaire: A measure of parenting principles and practices during infancy. Infant Behavior & Development, 36, 762775.

Keywords

Metrics

Altmetric attention score

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Abstract views

Total abstract views: 0 *
Loading metrics...

* Views captured on Cambridge Core between <date>. This data will be updated every 24 hours.

Usage data cannot currently be displayed